Chapter 9 : Epidemiology of Bloodstream Infections

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The detection of microorganisms in the setting of bloodstream infection is one of the most important functions of the clinical microbiology laboratory. A number of advances and practice changes in health care, including hematopoietic stem cell transplantation (HSCT) and solid organ transplantation (SOT) and resulting immunosuppressive regimens, as well as the aging population, emergence of antimicrobial resistance, and increased use of invasive procedures in health care settings (as well as improvements in blood culture methods), have resulted in changing epidemiology of bloodstream infections over the past 4 decades. This chapter will discuss trends in the epidemiology of positive blood cultures.

Citation: McMullen A, Wilen C, Burnham C. 2017. Epidemiology of Bloodstream Infections, p 163-181. In Dunne, Jr. W, Burnham C (ed), The Dark Art of Blood Cultures. ASM Press, Washington, DC. doi: 10.1128/9781555819811.ch9
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Figure 1

Overview of bacteria most commonly associated with bloodstream infections.

Citation: McMullen A, Wilen C, Burnham C. 2017. Epidemiology of Bloodstream Infections, p 163-181. In Dunne, Jr. W, Burnham C (ed), The Dark Art of Blood Cultures. ASM Press, Washington, DC. doi: 10.1128/9781555819811.ch9
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Figure 2

The organisms most frequently recovered from blood cultures, 1975 to 2015. ( ) Weinstein et al., 1983; ( ) Cockerill et al., 1997; ( ) Weinstein et al., 1997; ( ) Wisplinghoff et al., 2004; ( ) Biedenbach et al., 2004; ( ) Pien et al., 2010.

Citation: McMullen A, Wilen C, Burnham C. 2017. Epidemiology of Bloodstream Infections, p 163-181. In Dunne, Jr. W, Burnham C (ed), The Dark Art of Blood Cultures. ASM Press, Washington, DC. doi: 10.1128/9781555819811.ch9
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Figure 3

Overview of fungi most commonly associated with bloodstream infections.

Citation: McMullen A, Wilen C, Burnham C. 2017. Epidemiology of Bloodstream Infections, p 163-181. In Dunne, Jr. W, Burnham C (ed), The Dark Art of Blood Cultures. ASM Press, Washington, DC. doi: 10.1128/9781555819811.ch9
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Table 1

Microorganisms isolated from positive blood cultures at a tertiary care academic medical center, 2014 to 2015

Citation: McMullen A, Wilen C, Burnham C. 2017. Epidemiology of Bloodstream Infections, p 163-181. In Dunne, Jr. W, Burnham C (ed), The Dark Art of Blood Cultures. ASM Press, Washington, DC. doi: 10.1128/9781555819811.ch9

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