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Chapter 11 : BCG and New Vaccines for the Prevention of Tuberculosis

Authors: Timothy Lahey1, C. Fordham von Reyn4
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Affiliations: 1: Dartmouth’s Geisel School of Medicine; 2: Section of Infectious Diseases and International Health, Dartmouth-Hitchcock Medical Center; 3: The Dartmouth Institute for Clinical Practice & Health Policy, Lebanon, NH 03756; 4: Dartmouth’s Geisel School of Medicine; 5: Section of Infectious Diseases and International Health, Dartmouth-Hitchcock Medical Center
Content Type: Monograph
Publication Year: 2017

Category: Bacterial Pathogenesis; Clinical Microbiology

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Abstract:

A critical component of global tuberculosis control is the development of more effective immunization strategies. Several tuberculosis vaccines have been shown to reduce the risk of disease and death due to tuberculosis in humans, but only one is used in global immunization programs: bacillus Calmette-Guérin (BCG). BCG is an attenuated live vaccine administered at birth to children in most countries where tuberculosis is endemic. BCG has been the most widely administered vaccine in the world, with an estimated three billion doses administered to date ( ). BCG has likely reduced the burden of tuberculosis in many areas, but it has numerous limitations. These limitations, together with the continuation of the global tuberculosis epidemic, have made the development of a more effective vaccine against tuberculosis a major international public health priority ( ).

Citation: Lahey T, von Reyn C. 2017. BCG and New Vaccines for the Prevention of Tuberculosis, p 187-209. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Seventh Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TNMI7-0003-2016
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Mycobacterium bovis BCG and New Vaccines for the Prevention of Tuberculosis
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Citation: Lahey T, von Reyn C. 2017. BCG and New Vaccines for the Prevention of Tuberculosis, p 187-209. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Seventh Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TNMI7-0003-2016
/content/10.1128/9781555819866.chap11.fig11-1
Figure 1

Selected vaccines in advanced human clinical trials. P, clinical trial demonstrated protection from tuberculosis; F, clinical trial failed to show protection from tuberculosis. Based on references to , and .

10.1128/9781555819866/fig11-1_thmb.gif
10.1128/9781555819866/fig11-1.gif
Image of Figure 1
Figure 1

Selected vaccines in advanced human clinical trials. P, clinical trial demonstrated protection from tuberculosis; F, clinical trial failed to show protection from tuberculosis. Based on references to , and .

Citation: Lahey T, von Reyn C. 2017. BCG and New Vaccines for the Prevention of Tuberculosis, p 187-209. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Seventh Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TNMI7-0003-2016
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