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Chapter 19 :

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Abstract:

Significant progress has been made in the last few years towards our understanding of the epidemiology, pathogenicity, and control of foodborne disease, including food poisoning, caused by strains. Despite this, a significant burden of food poisoning illnesses still occurs in the United States every year, with nearly a million cases reported. food poisoning commonly occurs as outbreaks in institutions where food is prepared in large quantities. Prophylactic measures to prevent food poisoning should focus on restricting multiplication of vegetative cells in cooked foods. Cooking at the proper temperature and for the right time, along with rapid cooling after cooking with subsequent refrigeration, is the most effective action to control the multiplication of and thus avoid food poisoning outbreaks. Processors can take advantage of multiple food formulation factors or hurdles in foods (e.g., water activity, pH, and added preservatives) to restrict growth from spores in cooked foods. Predictive models have been developed to estimate growth under conditions that are relevant to food processing operations. Recent advances in molecular techniques have enabled researchers to characterize virulence factors, toxins, sporulation, spore heat resistance, to carry out epidemiologic trace-back of foodborne illness and toxigenic typing methods, etc. Future research efforts should be directed towards efficient tracing of strains of public health significance, multiple hurdles in formulated foods, proper processing of ready-to-eat foods, and consumer awareness of handling of such foods.

Citation: García S, Vidal J, Heredia N, Juneja V. 2019. , p 513-540. In Doyle M, Diez-Gonzalez F, Hill C (ed), Food Microbiology: Fundamentals and Frontiers, 5th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819972.ch19
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Figures

Image of Figure 19.1
Figure 19.1

Electron micrograph of thin sections of FD-1041. Arrows indicate a spore and a CPE containing round inclusion body. Magnification, ×40,000. Bar, 0.5 μ. Reproduced with permission from reference .

Citation: García S, Vidal J, Heredia N, Juneja V. 2019. , p 513-540. In Doyle M, Diez-Gonzalez F, Hill C (ed), Food Microbiology: Fundamentals and Frontiers, 5th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819972.ch19
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Image of Figure 19.2
Figure 19.2

CpAL regulation of virulence factors ( ). CpAL is encoded by and , whose products are the AgrD signaling peptide (inset) and a transmembrane protein (AgrB) involved in its processing. The AgrD peptide is sensed by the membrane sensor (VirS), which in turn phosphorylates VirR, the response regulator. Upon CpAL activation, VirR directly upregulates transcription of several toxin genes or a small VR-RNA which ultimately activates expression of and . Whether VirR upregulates transcription of the CpAL operon is not clear.

Citation: García S, Vidal J, Heredia N, Juneja V. 2019. , p 513-540. In Doyle M, Diez-Gonzalez F, Hill C (ed), Food Microbiology: Fundamentals and Frontiers, 5th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819972.ch19
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Image of Figure 19.3
Figure 19.3

Histological damage is induced by lysates. Tissue specimens shown were collected from rabbit ileal loops treated with either concentrated vegetative (FTG) or concentrated sporulating (DS) culture lysates of wild-type, mutant, or complemented strains. Tissue specimens shown were treated with 50-fold-concentrated DS or FTG (as indicated) lysates of wild-type SM101, knockout mutant MRS101, or complemented strain MRS101(pJRC200). Tissue specimens treated with 50-fold-concentrated FTG lysates prepared from either MRS101 or complemented strain MRS101(pJRC200) were indistinguishable from specimens treated with FTG lysates of SM101 (data not shown).

Citation: García S, Vidal J, Heredia N, Juneja V. 2019. , p 513-540. In Doyle M, Diez-Gonzalez F, Hill C (ed), Food Microbiology: Fundamentals and Frontiers, 5th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819972.ch19
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Figure 19.4

Detection of CPA on biofilms. Strain S13Δplc or S13Δplc/plc was inoculated into a four-well chamber slide containing tryptone glucose yeast extract, followed by incubation for 24 h at 37°C. Bacteria were stained with SYTO9, and CPA was detected using rabbit polyclonal anti- CPA antibodies, followed by goat anti-rabbit immunoglobulin secondary antibodies conjugated to Alexa Fluor 555. Optical middle and top sections were obtained with a confocal microscope. Arrows point to areas of colocalization.

Citation: García S, Vidal J, Heredia N, Juneja V. 2019. , p 513-540. In Doyle M, Diez-Gonzalez F, Hill C (ed), Food Microbiology: Fundamentals and Frontiers, 5th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819972.ch19
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Image of Figure 19.5
Figure 19.5

Pathogenesis of type A food poisoning. Vegetative cells of an enterotoxin (CPE)-producing strain multiply rapidly in contaminated food (usually a meat or poultry product) and, after ingestion, sporulate in the small intestine. Sporulated cells then produce CPE, which is released at the completion of sporulation, when the mother cell lyses to release its endospore. CPE then causes morphologic damage to the small intestine, resulting in diarrhea and abdominal cramps. Modified and reproduced with permission from reference .

Citation: García S, Vidal J, Heredia N, Juneja V. 2019. , p 513-540. In Doyle M, Diez-Gonzalez F, Hill C (ed), Food Microbiology: Fundamentals and Frontiers, 5th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819972.ch19
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