Chapter 31 : Diet, Health, and the Gut Microbiota

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This chapter details well-established ideas within the microbiome field relating to the interplay between our microbiota and diet and their associations with long-term health over the course of our lives. The chapter details what the microbiota and microbiome are, how the microbiota is established, and how nutrition plays a major role in the progression of the microbiota throughout our lives. Initially the chapter details the establishment of the microbiota and the influence of early-life diet. It characterizes the progression to a more adult-like microbiota due to dietary changes and places the adult microbiota in the context of the different dietary and lifestyle choices we make as adults, the influence these have on our body mass index, and how this may influence our health. Finally, we detail the effect of diet and the microbiota on our health as we reach an advanced age and how the microbiota may be maintained or modulated through diet.

Citation: Hill C, de Filippis F, Jeffery I. 2019. Diet, Health, and the Gut Microbiota, p 815-829. In Doyle M, Diez-Gonzalez F, Hill C (ed), Food Microbiology: Fundamentals and Frontiers, 5th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819972.ch31
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Figure 31.1

Factors influencing the establishment of the infant microbiota. The development of the microbiota from the womb to adult-like functional maturity as a toddler is influenced by a myriad of factors. An overview of some of the current knowledge surrounding this developmental process is outlined conceptually.

Citation: Hill C, de Filippis F, Jeffery I. 2019. Diet, Health, and the Gut Microbiota, p 815-829. In Doyle M, Diez-Gonzalez F, Hill C (ed), Food Microbiology: Fundamentals and Frontiers, 5th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819972.ch31
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Image of Figure 31.2
Figure 31.2

Microbiome-diet interaction. The type of diet consumed affects the quantity and nature of the microbial metabolites produced. These metabolites can have beneficial or deleterious effects on the host. NOCs, -nitroso compounds.

Citation: Hill C, de Filippis F, Jeffery I. 2019. Diet, Health, and the Gut Microbiota, p 815-829. In Doyle M, Diez-Gonzalez F, Hill C (ed), Food Microbiology: Fundamentals and Frontiers, 5th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819972.ch31
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1. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. 2012. Diversity, stability and resilience of the human gut microbiota. Nature 489 : 220 230[CrossRef].[PubMed]
2. Costea PI, Hildebrand F, Arumugam M, Bäckhed F, Blaser MJ, Bushman FD, de Vos WM, Ehrlich SD, Fraser CM, Hattori M, Huttenhower C, Jeffery IB, Knights D, Lewis JD, Ley RE, Ochman H, O'Toole PW, Quince C, Relman DA, Shanahan F, Sunagawa S, Wang J, Weinstock GM, Wu GD, Zeller G, Zhao L, Raes J, Knight R, Bork P. 2018. Enterotypes in the landscape of gut microbial community composition. Nat Microbiol 3 : 8 16. CORRECTION Nat Microbiol 3 : 388[CrossRef].[PubMed]
3. Funkhouser LJ, Bordenstein SR. 2013. Mom knows best: the universality of maternal microbial transmission. PLoS Biol 11 : e1001631[CrossRef].[PubMed]
4. Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI. 2012. Human gut microbiome viewed across age and geography. Nature 486 : 222 227[CrossRef].[PubMed]
5. De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P . 2010. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 107 : 14691 14696.
6. Aagaard K, Riehle K, Ma J, Segata N, Mistretta T-A, Coarfa C, Raza S, Rosenbaum S, Van den Veyver I, Milosavljevic A, Gevers D, Huttenhower C, Petrosino J, Versalovic J . 2012. A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy. PLoS One 7 : e36466.
7. van Nimwegen FA, Penders J, Stobberingh EE, Postma DS, Koppelman GH, Kerkhof M, Reijmerink NE, Dompeling E, van den Brandt PA, Ferreira I, Mommers M, Thijs C . 2011. Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol 128 : 948 955.e3.
8. Biasucci G, Benenati B, Morelli L, Bessi E, Boehm G. 2008. Cesarean delivery may affect the early biodiversity of intestinal bacteria. J Nutr 138 : 1796S 1800S[CrossRef].[PubMed]
9. Azad MB, Konya T, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL. 2014. Impact of cesarean section delivery and breastfeeding on infant gut microbiota at one year of age. Allergy Asthma Clin Immunol 10( Suppl 1) : A24[CrossRef].
10. Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I, van den Brandt PA, Stobberingh EE. 2006. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 118 : 511 521[CrossRef].[PubMed]
11. Jakobsson HE, Abrahamsson TR, Jenmalm MC, Harris K, Quince C, Jernberg C, Björkstén B, Engstrand L, Andersson AF. 2014. Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut 63 : 559 566[CrossRef].[PubMed]
12. Adlerberth I, Strachan DP, Matricardi PM, Ahrné S, Orfei L, Aberg N, Perkin MR, Tripodi S, Hesselmar B, Saalman R, Coates AR, Bonanno CL, Panetta V, Wold AE. 2007. Gut microbiota and development of atopic eczema in 3 European birth cohorts. J Allergy Clin Immunol 120 : 343 350[CrossRef].[PubMed]
13. Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R. 2011. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology 140 : 1713 1719[CrossRef].[PubMed]
14. Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL CHILD Study Investigators. 2013. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ 185 : 385 394[CrossRef].[PubMed]
15. Bäckhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P, Li Y, Xia Y, Xie H, Zhong H, Khan MT, Zhang J, Li J, Xiao L, Al-Aama J, Zhang D, Lee YS, Kotowska D, Colding C, Tremaroli V, Yin Y, Bergman S, Xu X, Madsen L, Kristiansen K, Dahlgren J, Wang J. 2015. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17 : 690 703. ERRATUM Cell Host Microbe 17 : P852[CrossRef].[PubMed]
16. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R . 2010. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 107 : 11971 11975.
17. Lif Holgerson P, Harnevik L, Hernell O, Tanner ACR, Johansson I. 2011. Mode of birth delivery affects oral microbiota in infants. J Dent Res 90 : 1183 1188[CrossRef].[PubMed]
18. Brooks B, Firek BA, Miller CS, Sharon I, Thomas BC, Baker R, Morowitz MJ, Banfield JF. 2014. Microbes in the neonatal intensive care unit resemble those found in the gut of premature infants. Microbiome 2 : 1[CrossRef].[PubMed]
19. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. 2007. Development of the human infant intestinal microbiota. PLoS Biol 5 : e177[CrossRef].[PubMed]
20. Šrůtková D, Spanova A, Spano M, Dráb V, Schwarzer M, Kozaková H, Rittich B. 2011. Efficiency of PCR-based methods in discriminating Bifidobacterium longum ssp. longum and Bifidobacterium longum ssp. infantis strains of human origin. J Microbiol Methods 87 : 10 16[CrossRef].[PubMed]
21. Madan JC, Salari RC, Saxena D, Davidson L, O'Toole GA, Moore JH, Sogin ML, Foster JA, Edwards WH, Palumbo P, Hibberd PL. 2012. Gut microbial colonisation in premature neonates predicts neonatal sepsis. Arch Dis Child Fetal Neonatal Ed 97 : F456 F462[CrossRef].[PubMed]
22. Scholtens PAMJ, Oozeer R, Martin R, Amor KB, Knol J. 2012. The early settlers: intestinal microbiology in early life. Annu Rev Food Sci Technol 3 : 425 447[CrossRef].[PubMed]
23. Hill CJ, Lynch DB, Murphy K, Ulaszewska M, Jeffery IB, O'Shea CA, Watkins C, Dempsey E, Mattivi F, Tuohy K, Ross RP, Ryan CA, O’ Toole PW, Stanton C. 2017. Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort. Microbiome 5 : 4. ERRATUM Microbiome 5 : 21[CrossRef].[PubMed]
24. Jain N, Walker WA. 2015. Diet and host-microbial crosstalk in postnatal intestinal immune homeostasis. Nat Rev Gastroenterol Hepatol 12 : 14 25[CrossRef].[PubMed]
25. Hinde K, Foster AB, Landis LM, Rendina D, Oftedal OT, Power ML. 2013. Daughter dearest: sex-biased calcium in mother's milk among rhesus macaques. Am J Phys Anthropol 151 : 144 150[CrossRef].[PubMed]
26. Sela DA, Mills DA. 2014. The marriage of nutrigenomics with the microbiome: the case of infant-associated bifidobacteria and milk. Am J Clin Nutr 99 : 697S 703S[CrossRef].[PubMed]
27. Simeoni U, Berger B, Junick J, Blaut M, Pecquet S, Rezzonico E, Grathwohl D, Sprenger N, Brüssow H, Szajewska H . 2015. Gut microbiota analysis reveals a marked shift to bifidobacteria by a starter infant formula containing a synbiotic of bovine milk-derived oligosaccharides and Bifidobacterium animalis subsp. lactis CNCM I-3446. Environ Microbiol 18 : 2185 2195.
28. Gale C, Logan KM, Santhakumaran S, Parkinson JRC, Hyde MJ, Modi N. 2012. Effect of breastfeeding compared with formula feeding on infant body composition: a systematic review and meta-analysis. Am J Clin Nutr 95 : 656 669[CrossRef].[PubMed]
29. Innis SM. 2007. Human milk: maternal dietary lipids and infant development. Proc Nutr Soc 66 : 397 404[CrossRef].[PubMed]
30. Guaraldi F, Salvatori G. 2012. Effect of breast and formula feeding on gut microbiota shaping in newborns. Front Cell Infect Microbiol 2 : 94[CrossRef].[PubMed]
31. Jacquot A, Neveu D, Aujoulat F, Mercier G, Marchandin H, Jumas-Bilak E, Picaud J-C. 2011. Dynamics and clinical evolution of bacterial gut microflora in extremely premature patients. J Pediatr 158 : 390 396[CrossRef].[PubMed]
32. Mai V, Torrazza RM, Ukhanova M, Wang X, Sun Y, Li N, Shuster J, Sharma R, Hudak ML, Neu J. 2013. Distortions in development of intestinal microbiota associated with late onset sepsis in preterm infants. PLoS One 8 : e52876[CrossRef].[PubMed]
33. Maynard CL, Elson CO, Hatton RD, Weaver CT. 2012. Reciprocal interactions of the intestinal microbiota and immune system. Nature 489 : 231 241[CrossRef].[PubMed]
34. Jeffery IB, Claesson MJ, O'Toole PW, Shanahan F. 2012. Categorization of the gut microbiota: enterotypes or gradients ? Nat Rev Microbiol 10 : 591 592.
35. Knights D, Ward TL, McKinlay CE, Miller H, Gonzalez A, McDonald D, Knight R. 2014. Rethinking “enterotypes.” Cell Host Microbe 16 : 433 437[CrossRef].[PubMed]
36. Wu GD, Chen J, Hoffmann C, Bittinger K, Chen Y-Y, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K, Baldassano R, Nessel L, Li H, Bushman FD, Lewis JD. 2011. Linking long-term dietary patterns with gut microbial enterotypes. Science 334 : 105 108[CrossRef].[PubMed]
37. Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Pudlo NA, Kitamoto S, Terrapon N, Muller A, Young VB, Henrissat B, Wilmes P, Stappenbeck TS, Núñez G, Martens EC. 2016. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell 167 : 1339 1353.E21[CrossRef].[PubMed]
38. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI. 2009. A core gut microbiome in obese and lean twins. Nature 457 : 480 484[CrossRef].[PubMed]
39. Davis SC, Yadav JS, Barrow SD, Robertson BK. 2017. Gut microbiome diversity influenced more by the Westernized dietary regime than the body mass index as assessed using effect size statistic. MicrobiologyOpen 6 : e00476[CrossRef].[PubMed]
40. Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. 2005. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 102 : 11070 11075[CrossRef].[PubMed]
41. Sze MA, Schloss PD. 2016. Looking for a signal in the noise: revisiting obesity and the microbiome. mBio 7 : e01018-16. ERRATUM mBio 8 : e01995-17[CrossRef].[PubMed]
42. Aron-Wisnewsky J, Prifti E, Belda E, Ichou F, Kayser BD, Dao MC, Verger EO, Hedjazil L, Bouillot J-L, Chevallier J-M, Pons N, Chatelier EL, Levenez F, Ehrlich SD, Dore J, Zucker J-D, Clément K . 2018. Major microbiota dysbiosis in severe obesity: fate after bariatric surgery. Gut 2018 :gutjnl-2018-316103.
43. Obregon-Tito AJ, Tito RY, Metcalf J, Sankaranarayanan K, Clemente JC, Ursell LK, Zech Xu Z, Van Treuren W, Knight R, Gaffney PM, Spicer P, Lawson P, Marin-Reyes L, Trujillo-Villarroel O, Foster M, Guija-Poma E, Troncoso-Corzo L, Warinner C, Ozga AT, Lewis CM. 2015. Subsistence strategies in traditional societies distinguish gut microbiomes. Nat Commun 6 : 6505[CrossRef].[PubMed]
44. Schnorr SL, Candela M, Rampelli S, Centanni M, Consolandi C, Basaglia G, Turroni S, Biagi E, Peano C, Severgnini M, Fiori J, Gotti R, De Bellis G, Luiselli D, Brigidi P, Mabulla A, Marlowe F, Henry AG, Crittenden AN. 2014. Gut microbiome of the Hadza hunter-gatherers. Nat Commun 5 : 3654[CrossRef].[PubMed]
45. Gomez A, Rothman JM, Petrzelkova K, Yeoman CJ, Vlckova K, Umaña JD, Carr M, Modry D, Todd A, Torralba M, Nelson KE, Stumpf RM, Wilson BA, Blekhman R, White BA, Leigh SR. 2016. Temporal variation selects for diet-microbe co-metabolic traits in the gut of Gorilla spp. ISME J 10 : 514 526. CORRIGENDUM ISME J 10 : 532[CrossRef].[PubMed]
46. Ley RE, Hamady M, Lozupone C, Turnbaugh PJ, Ramey RR, Bircher JS, Schlegel ML, Tucker TA, Schrenzel MD, Knight R, Gordon JI. 2008. Evolution of mammals and their gut microbes. Science 320 : 1647 1651[CrossRef].[PubMed]
47. Ochman H, Worobey M, Kuo C-H, Ndjango J-BN, Peeters M, Hahn BH, Hugenholtz P. 2010. Evolutionary relationships of wild hominids recapitulated by gut microbial communities. PLoS Biol 8 : e1000546[CrossRef].[PubMed]
48. Martínez I, Stegen JC, Maldonado-Gómez MX, Eren AM, Siba PM, Greenhill AR, Walter J. 2015. The gut microbiota of rural papua new guineans: composition, diversity patterns, and ecological processes. Cell Reports 11 : 527 538[CrossRef].[PubMed]
49. Gomez A, Petrzelkova KJ, Burns MB, Yeoman CJ, Amato KR, Vlckova K, Modry D, Todd A, Jost Robinson CA, Remis MJ, Torralba MG, Morton E, Umaña JD, Carbonero F, Gaskins HR, Nelson KE, Wilson BA, Stumpf RM, White BA, Leigh SR, Blekhman R. 2016. Gut microbiome of coexisting BaAka pygmies and Bantu reflects gradients of traditional subsistence patterns. Cell Reports 14 : 2142 2153[CrossRef].[PubMed]
50. Rampelli S, Schnorr SL, Consolandi C, Turroni S, Severgnini M, Peano C, Brigidi P, Crittenden AN, Henry AG, Candela M. 2015. Metagenome sequencing of the Hadza hunter-gatherer gut microbiota. Curr Biol 25 : 1682 1693[CrossRef].[PubMed]
51. Louis P, Hold GL, Flint HJ. 2014. The gut microbiota, bacterial metabolites and colorectal cancer. Nat Rev Microbiol 12 : 661 672[CrossRef].[PubMed]
52. O'Keefe SJD. 2016. Diet, microorganisms and their metabolites, and colon cancer. Nat Rev Gastroenterol Hepatol 13 : 691 706[CrossRef].[PubMed]
53. Cardona F, Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. 2013. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem 24 : 1415 1422[CrossRef].[PubMed]
54. Loh YH, Jakszyn P, Luben RN, Mulligan AA, Mitrou PN, Khaw K-T. 2011. N-Nitroso compounds and cancer incidence: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study. Am J Clin Nutr 93 : 1053 1061[CrossRef].[PubMed]
55. Ou J, Carbonero F, Zoetendal EG, DeLany JP, Wang M, Newton K, Gaskins HR, O'Keefe SJD. 2013. Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. Am J Clin Nutr 98 : 111 120[CrossRef].[PubMed]
56. Tang WHW, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. 2013. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 368 : 1575 1584[CrossRef].[PubMed]
57. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung Y-M, Wu Y, Schauer P, Smith JD, Allayee H, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL. 2011. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472 : 57 63[CrossRef].[PubMed]
58. Nemati R, Dietz C, Anstadt EJ, Cervantes J, Liu Y, Dewhirst FE, Clark RB, Finegold S, Gallagher JJ, Smith MB, Yao X, Nichols FC. 2017. Deposition and hydrolysis of serine dipeptide lipids of Bacteroidetes bacteria in human arteries: relationship to atherosclerosis. J Lipid Res 58 : 1999 2007[CrossRef].[PubMed]
59. Melina V, Craig W, Levin S. 2016. Position of the Academy of Nutrition and Dietetics: vegetarian diets. J Acad Nutr Diet 116 : 1970 1980[CrossRef].[PubMed]
60. De Filippis F, Pellegrini N, Vannini L, Jeffery IB, La Storia A, Laghi L, Serrazanetti DI, Di Cagno R, Ferrocino I, Lazzi C, Turroni S, Cocolin L, Brigidi P, Neviani E, Gobbetti M, O'Toole PW, Ercolini D. 2016. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut 65 : 1812 1821[CrossRef].[PubMed]
61. Magee PJ . 2011. Is equol production beneficial to health? Proc Nutr Soc 70 : 10 18.
62. Trichopoulou A, Kouris-Blazos A, Vassilakou T, Gnardellis C, Polychronopoulos E, Venizelos M, Lagiou P, Wahlqvist ML, Trichopoulos D. 1995. Diet and survival of elderly Greeks: a link to the past. Am J Clin Nutr 61( Suppl) : 1346S 1350S[CrossRef].[PubMed]
63. Estruch R, Ros E, Salas-Salvadó J, Covas M-I, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Fitó M, Gea A, Hernán MA, Martínez-González MA PREDIMED Study Investigators. 2018. Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts. N Engl J Med 378 : e34[CrossRef].[PubMed]
64. Salas-Salvadó J, Bulló M, Babio N, Martínez-González , Ibarrola-Jurado N, Basora J, Estruch R, Covas MI, Corella D, Arós F, Ruiz-Gutiérrez V, Ros E PREDIMED Study Investigators. 2011. Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care 34 : 14 19. ERRATUM Diabetes Care 41 : 2259 2260[CrossRef].[PubMed]
65. Santoro A, , et al, NU-AGE Consortium. 2014. Combating inflammaging through a Mediterranean whole diet approach: the NU-AGE project's conceptual framework and design. Mech Ageing Dev 136-137 : 3 13[CrossRef].[PubMed]
66. Biagi E, Rampelli S, Turroni S, Quercia S, Candela M, Brigidi P. 2017. The gut microbiota of centenarians: signatures of longevity in the gut microbiota profile. Mech Ageing Dev 165( Pt B) : 180 184[CrossRef].[PubMed]
67. Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, Cusack S, Harris HMB, Coakley M, Lakshminarayanan B, O'Sullivan O, Fitzgerald GF, Deane J, O'Connor M, Harnedy N, O'Connor K, O'Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, Ross RP, O'Toole PW. 2012. Gut microbiota composition correlates with diet and health in the elderly. Nature 488 : 178 184[CrossRef].[PubMed]
68. Jeffery IB, Lynch DB, O'Toole PW. 2016. Composition and temporal stability of the gut microbiota in older persons. ISME J 10 : 170 182[CrossRef].[PubMed]
69. Bian G, Gloor GB, Gong A, Jia C, Zhang W, Hu J, Zhang H, Zhang Y, Zhou Z, Zhang J, Burton JP, Reid G, Xiao Y, Zeng Q, Yang K, Li J. 2017. The gut microbiota of healthy aged Chinese is similar to that of the healthy young. mSphere 2 :e00327-17[CrossRef].[PubMed]
70. Jackson MA, Jeffery IB, Beaumont M, Bell JT, Clark AG, Ley RE, O'Toole PW, Spector TD, Steves CJ. 2016. Signatures of early frailty in the gut microbiota. Genome Med 8 : 8. ERRATUM Genome Med 8 : 21[CrossRef].[PubMed]
71. Rampelli S, Candela M, Turroni S, Biagi E, Collino S, Franceschi C, O'Toole PW, Brigidi P. 2013. Functional metagenomic profiling of intestinal microbiome in extreme ageing. Aging (Albany NY) 5 : 902 912[CrossRef].[PubMed]
72. Biagi E, Nylund L, Candela M, Ostan R, Bucci L, Pini E, Nikkïla J, Monti D, Satokari R, Franceschi C, Brigidi P, De Vos W. 2010. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One 5 : e10667. CORRECTION PLoS One 5[CrossRef].[PubMed]
73. Mäkivuokko H, Tiihonen K, Tynkkynen S, Paulin L, Rautonen N. 2010. The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition. Br J Nutr 103 : 227 234[CrossRef].[PubMed]
74. Rémond D, Shahar DR, Gille D, Pinto P, Kachal J, Peyron M-A, Dos Santos CN, Walther B, Bordoni A, Dupont D, Tomás-Cobos L, Vergères G. 2015. Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition. Oncotarget 6 : 13858 13898[CrossRef].[PubMed]
75. Seganfredo FB, Blume CA, Moehlecke M, Giongo A, Casagrande DS, Spolidoro JVN, Padoin AV, Schaan BD, Mottin CC. 2017. Weight-loss interventions and gut microbiota changes in overweight and obese patients: a systematic review. Obes Rev 18 : 832 851[CrossRef].[PubMed]
76. Vanegas SM, Meydani M, Barnett JB, Goldin B, Kane A, Rasmussen H, Brown C, Vangay P, Knights D, Jonnalagadda S, Koecher K, Karl JP, Thomas M, Dolnikowski G, Li L, Saltzman E, Wu D, Meydani SN. 2017. Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults. Am J Clin Nutr 105 : 635 650[CrossRef].[PubMed]
77. Vitaglione P, Mennella I, Ferracane R, Rivellese AA, Giacco R, Ercolini D, Gibbons SM, La Storia A, Gilbert JA, Jonnalagadda S, Thielecke F, Gallo MA, Scalfi L, Fogliano V. 2015. Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber. Am J Clin Nutr 101 : 251 261[CrossRef].[PubMed]
78. Kovatcheva-Datchary P, Nilsson A, Akrami R, Lee YS, De Vadder F, Arora T, Hallen A, Martens E, Björck I, Bäckhed F. 2015. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab 22 : 971 982[CrossRef].[PubMed]
79. Zeevi D, Korem T, Zmora N, Israeli D, Rothschild D, Weinberger A, Ben-Yacov O, Lador D, Avnit-Sagi T, Lotan-Pompan M, Suez J, Mahdi JA, Matot E, Malka G, Kosower N, Rein M, Zilberman-Schapira G, Dohnalová L, Pevsner-Fischer M, Bikovsky R, Halpern Z, Elinav E, Segal E. 2015. Personalized nutrition by prediction of glycemic responses. Cell 163 : 1079 1094[CrossRef].[PubMed]

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