Chapter 16 : Bacterial Iron Homeostasis Regulation by sRNAs

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in

Bacterial Iron Homeostasis Regulation by sRNAs, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781683670247/9781683670230_Chap16-1.gif /docserver/preview/fulltext/10.1128/9781683670247/9781683670230_Chap16-2.gif


Iron is one of the most abundant elements on earth. Due to its chemical properties, in particular its redox potential, it was used as a cofactor in a large number of proteins since the emergence of life. Before the appearance of an oxidative atmosphere, iron was found mainly in its reduced, ferrous form (Fe). Fe is typically the bioreactive form of iron that is found in proteins, as an isolated ion, in the center of porphyrin to form heme, or in coordination with sulfur atoms to constitute so-called Fe-S cluster cofactors ( ). Bacteria contain many iron-using proteins involved in a plethora of reactions, mainly, but not limited to, aerobic and anaerobic respiration, the tricarboxylic acid (TCA) cycle, photosynthesis, N fixation, and DNA biosynthesis.

Citation: Chareyre S, Mandin P. 2019. Bacterial Iron Homeostasis Regulation by sRNAs, p 267-281. In Storz G, Papenfort K (ed), Regulating with RNA in Bacteria and Archaea. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.RWR-0010-2017
Highlighted Text: Show | Hide
Loading full text...

Full text loading...


Image of Figure 1
Figure 1

RyhB regulatory mechanisms. (A) RyhB represses expression of multiple mRNAs by inhibiting translation initiation and inducing mRNA degradation. RyhB base-pairing blocks ribosome attachment to the RBS. Consequently, the mRNA is degraded by RNase E recruitment at sites that can be distant from the base-pairing region. (B) RyhB promotes the degradation of the transcript by base-pairing to the translation initiation region of while the 5′ part of the mRNA, encoding , remains stable and is translated. (C) RyhB positively regulates expression by opening a stem-loop structure that otherwise inhibits ribosome attachment to the RBS. (D) RyhB activates translation of by displacing Hfq, which otherwise blocks ribosome attachment. (E) RyhB’s activity can be modulated thanks to the 3′ external transcribed spacer of the tRNA (in purple).

Citation: Chareyre S, Mandin P. 2019. Bacterial Iron Homeostasis Regulation by sRNAs, p 267-281. In Storz G, Papenfort K (ed), Regulating with RNA in Bacteria and Archaea. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.RWR-0010-2017
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 2
Figure 2

The iron-sparing response established by RyhB. Under iron-replete conditions, Fur-Fe represses expression. During iron starvation, Fur repression is abolished and RyhB is rapidly expressed. RyhB mediates an Fe-sparing response through three mechanisms: (A) RyhB represses the expression of mRNAs coding for iron-using proteins; (B) RyhB, together with IscR, orchestrates Fe-S biogenesis systems through regulation of the Isc machinery and expression; and (C) RyhB promotes Fe uptake via the upregulation of and and repression of the gene, which leads to serine accumulation used for enterobactin production.

Citation: Chareyre S, Mandin P. 2019. Bacterial Iron Homeostasis Regulation by sRNAs, p 267-281. In Storz G, Papenfort K (ed), Regulating with RNA in Bacteria and Archaea. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.RWR-0010-2017
Permissions and Reprints Request Permissions
Download as Powerpoint


1. Andrews SC,, Robinson AK,, Rodríguez-Quiñones F . 2003. Bacterial iron homeostasis. FEMS Microbiol Rev 27 : 215 237.[PubMed]
2. Frawley ER,, Fang FC . 2014. The ins and outs of bacterial iron metabolism. Mol Microbiol 93 : 609 616.[PubMed]
3. Py B,, Moreau PL,, Barras F . 2011. Fe-S clusters, fragile sentinels of the cell. Curr Opin Microbiol 14 : 218 223.[PubMed]
4. Miethke M,, Marahiel MA . 2007. Siderophore-based iron acquisition and pathogen control. Microbiol Mol Biol Rev 71 : 413 451.[PubMed]
5. Fischbach MA,, Lin H,, Liu DR,, Walsh CT . 2006. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat Chem Biol 2 : 132 138.[PubMed]
6. Imlay JA . 2006. Iron-sulphur clusters and the problem with oxygen. Mol Microbiol 59 : 1073 1082.[PubMed]
7. Imlay JA . 2013. The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium. Nat Rev Microbiol 11 : 443 454.[PubMed]
8. Imlay JA . 2014. The mismetallation of enzymes during oxidative stress. J Biol Chem 289 : 28121 28128.[PubMed]
9. Braun V . 2003. Iron uptake by Escherichia coli. Front Biosci 8 : s1409 s1421.[PubMed]
10. Lee JW,, Helmann JD . 2007. Functional specialization within the Fur family of metalloregulators. Biometals 20 : 485 499.[PubMed]
11. Beauchene NA,, Myers KS,, Chung D,, Park DM,, Weisnicht AM,, Keleş S,, Kiley PJ . 2015. Impact of anaerobiosis on expression of the iron-responsive Fur and RyhB regulons. mBio 6 : e01947–e15.[CrossRef][PubMed]
12. Seo SW,, Kim D,, Latif H,, O’Brien EJ,, Szubin R,, Palsson BO . 2014. Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli. Nat Commun 5 : 4910.[CrossRef]
13. Dubrac S,, Touati D . 2000. Fur positive regulation of iron superoxide dismutase in Escherichia coli: functional analysis of the sodB promoter. J Bacteriol 182 : 3802 3808.[PubMed]
14. Gruer MJ,, Guest JR . 1994. Two genetically-distinct and differentially-regulated aconitases (AcnA and AcnB) in Escherichia coli. Microbiology 140 : 2531 2541.[PubMed]
15. Massé E,, Gottesman S . 2002. A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli. Proc Natl Acad Sci U S A 99 : 4620 4625.[PubMed]
16. Massé E,, Escorcia FE,, Gottesman S . 2003. Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli. Genes Dev 17 : 2374 2383.[PubMed]
17. De Lay N,, Schu DJ,, Gottesman S . 2013. Bacterial small RNA-based negative regulation: Hfq and its accomplices. J Biol Chem 288 : 7996 8003.[PubMed]
18. Sauer E . 2013. Structure and RNA-binding properties of the bacterial LSm protein Hfq. RNA Biol 10 : 610 618.[PubMed]
19. Gottesman S,, Storz G . 2011. Bacterial small RNA regulators: versatile roles and rapidly evolving variations. Cold Spring Harb Perspect Biol 3 : a003798.[CrossRef]
20. Prévost K,, Desnoyers G,, Jacques JF,, Lavoie F,, Massé E . 2011. Small RNA-induced mRNA degradation achieved through both translation block and activated cleavage. Genes Dev 25 : 385 396.[PubMed]
21. Morita T,, Maki K,, Aiba H . 2005. RNase E-based ribonucleoprotein complexes: mechanical basis of mRNA destabilization mediated by bacterial noncoding RNAs. Genes Dev 19 : 2176 2186.[PubMed]
22. Desnoyers G,, Morissette A,, Prévost K,, Massé E . 2009. Small RNA-induced differential degradation of the polycistronic mRNA iscRSUA. EMBO J 28 : 1551 1561.[PubMed]
23. Prévost K,, Salvail H,, Desnoyers G,, Jacques JF,, Phaneuf E,, Massé E . 2007. The small RNA RyhB activates the translation of shiA mRNA encoding a permease of shikimate, a compound involved in siderophore synthesis. Mol Microbiol 64 : 1260 1273.[PubMed]
24. Salvail H,, Caron M-P,, Bélanger J,, Massé E . 2013. Antagonistic functions between the RNA chaperone Hfq and an sRNA regulate sensitivity to the antibiotic colicin. EMBO J 32 : 2764 2778.[PubMed]
25. Battesti A,, Majdalani N,, Gottesman S . 2011. The RpoS-mediated general stress response in Escherichia coli. Annu Rev Microbiol 65 : 189 213.[PubMed]
26. Mandin P,, Gottesman S . 2010. Integrating anaerobic/aerobic sensing and the general stress response through the ArcZ small RNA. EMBO J 29 : 3094 3107.[PubMed]
27. Lalaouna D,, Carrier MC,, Semsey S,, Brouard JS,, Wang J,, Wade JT,, Massé E . 2015. A 3′ external transcribed spacer in a tRNA transcript acts as a sponge for small RNAs to prevent transcriptional noise. Mol Cell 58 : 393 405.[PubMed]
28. Jacques JF,, Jang S,, Prévost K,, Desnoyers G,, Desmarais M,, Imlay J,, Massé E . 2006. RyhB small RNA modulates the free intracellular iron pool and is essential for normal growth during iron limitation in Escherichia coli. Mol Microbiol 62 : 1181 1190.[PubMed]
29. Salvail H,, Lanthier-Bourbonnais P,, Sobota JM,, Caza M,, Benjamin JA,, Mendieta ME,, Lépine F,, Dozois CM,, Imlay J,, Massé E . 2010. A small RNA promotes siderophore production through transcriptional and metabolic remodeling. Proc Natl Acad Sci U S A 107 : 15223 15228.[PubMed]
30. Massé E,, Vanderpool CK,, Gottesman S . 2005. Effect of RyhB small RNA on global iron use in Escherichia coli. J Bacteriol 187 : 6962 6971.[PubMed]
31. Wang J,, Rennie W,, Liu C,, Carmack CS,, Prévost K,, Caron MP,, Massé E,, Ding Y,, Wade JT . 2015. Identification of bacterial sRNA regulatory targets using ribosome profiling. Nucleic Acids Res 43 : 10308 10320.
32. Melamed S,, Peer A,, Faigenbaum-Romm R,, Gatt YE,, Reiss N,, Bar A,, Altuvia Y,, Argaman L,, Margalit H . 2016. Global mapping of small RNA-target interactions in bacteria. Mol Cell 63 : 884 897.[PubMed]
33. Wright PR,, Richter AS,, Papenfort K,, Mann M,, Vogel J,, Hess WR,, Backofen R,, Georg J . 2013. Comparative genomics boosts target prediction for bacterial small RNAs. Proc Natl Acad Sci U S A 110 : E3487 E3496.[PubMed]
34. Loiseau L,, Gerez C,, Bekker M,, Ollagnier-de Choudens S,, Py B,, Sanakis Y,, Teixeira de Mattos J,, Fontecave M,, Barras F . 2007. ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. Proc Natl Acad Sci U S A 104 : 13626 13631.[PubMed]
35. Mandin P,, Chareyre S,, Barras F . 2016. A regulatory circuit composed of a transcription factor, IscR, and a regulatory RNA, RyhB, controls Fe-S cluster delivery. mBio 7 : e00966-16.[CrossRef]
36. Bos J,, Duverger Y,, Thouvenot B,, Chiaruttini C,, Branlant C,, Springer M,, Charpentier B,, Barras F . 2013. The sRNA RyhB regulates the synthesis of the Escherichia coli methionine sulfoxide reductase MsrB but not MsrA. PLoS One 8 : e63647.[CrossRef][PubMed]
37. Niederhoffer EC,, Naranjo CM,, Bradley KL,, Fee JA . 1990. Control of Escherichia coli superoxide dismutase ( sodA and sodB) genes by the ferric uptake regulation ( fur) locus. J Bacteriol 172 : 1930 1938.[PubMed]
38. Mettert EL,, Kiley PJ . 2015. How is Fe-S cluster formation regulated? Annu Rev Microbiol 69 : 505 526.[PubMed]
39. Roche B,, Aussel L,, Ezraty B,, Mandin P,, Py B,, Barras F . 2013. Iron/sulfur proteins biogenesis in prokaryotes: formation, regulation and diversity. Biochim Biophys Acta 1827 : 455 469.[PubMed]
40. Outten FW,, Djaman O,, Storz G . 2004. A suf operon requirement for Fe-S cluster assembly during iron starvation in Escherichia coli. Mol Microbiol 52 : 861 872.[PubMed]
41. Giel JL,, Nesbit AD,, Mettert EL,, Fleischhacker AS,, Wanta BT,, Kiley PJ . 2013. Regulation of iron-sulphur cluster homeostasis through transcriptional control of the Isc pathway by [2Fe-2S]-IscR in Escherichia coli. Mol Microbiol 87 : 478 492.[PubMed]
42. Mettert EL,, Kiley PJ . 2014. Coordinate regulation of the Suf and Isc Fe-S cluster biogenesis pathways by IscR is essential for viability of Escherichia coli. J Bacteriol 196 : 4315 4323.[PubMed]
43. Yeo WS,, Lee JH,, Lee KC,, Roe JH . 2006. IscR acts as an activator in response to oxidative stress for the suf operon encoding Fe-S assembly proteins. Mol Microbiol 61 : 206 218.[PubMed]
44. Giel JL,, Rodionov D,, Liu M,, Blattner FR,, Kiley PJ . 2006. IscR-dependent gene expression links iron-sulphur cluster assembly to the control of O 2-regulated genes in Escherichia coli. Mol Microbiol 60 : 1058 1075.[PubMed]
45. Py B,, Barras F . 2015. Genetic approaches of the Fe-S cluster biogenesis process in bacteria: historical account, methodological aspects and future challenges. Biochim Biophys Acta 1853 : 1429 1435.[PubMed]
46. Porcheron G,, Habib R,, Houle S,, Caza M,, Lépine F,, Daigle F,, Massé E,, Dozois CM . 2014. The small RNA RyhB contributes to siderophore production and virulence of uropathogenic Escherichia coli. Infect Immun 82 : 5056 5068.[PubMed]
47. Murphy ER,, Payne SM . 2007. RyhB, an iron-responsive small RNA molecule, regulates Shigella dysenteriae virulence. Infect Immun 75 : 3470 3477.[PubMed]
48. Oglesby AG,, Murphy ER,, Iyer VR,, Payne SM . 2005. Fur regulates acid resistance in Shigella flexneri via RyhB and ydeP. Mol Microbiol 58 : 1354 1367.[PubMed]
49. Broach WH,, Egan N,, Wing HJ,, Payne SM,, Murphy ER . 2012. VirF-independent regulation of Shigella virB transcription is mediated by the small RNA RyhB. PLoS One 7 : e38592.[CrossRef]
50. Davis BM,, Quinones M,, Pratt J,, Ding Y,, Waldor MK . 2005. Characterization of the small untranslated RNA RyhB and its regulon in Vibrio cholerae. J Bacteriol 187 : 4005 4014.[PubMed]
51. Mey AR,, Craig SA,, Payne SM . 2005. Characterization of Vibrio cholerae RyhB: the RyhB regulon and role of ryhB in biofilm formation. Infect Immun 73 : 5706 5719.[PubMed]
52. Kim JN . 2016. Roles of two RyhB paralogs in the physiology of Salmonella enterica. Microbiol Res 186–187 : 146 152.[PubMed]
53. Kim JN,, Kwon YM . 2013. Genetic and phenotypic characterization of the RyhB regulon in Salmonella Typhimurium. Microbiol Res 168 : 41 49.[PubMed]
54. Padalon-Brauch G,, Hershberg R,, Elgrably-Weiss M,, Baruch K,, Rosenshine I,, Margalit H,, Altuvia S . 2008. Small RNAs encoded within genetic islands of Salmonella typhimurium show host-induced expression and role in virulence. Nucleic Acids Res 36 : 1913 1927.[PubMed]
55. Calderón IL,, Morales EH,, Collao B,, Calderón PF,, Chahuán CA,, Acuña LG,, Gil F,, Saavedra CP . 2014. Role of Salmonella Typhimurium small RNAs RyhB-1 and RyhB-2 in the oxidative stress response. Res Microbiol 165 : 30 40.[PubMed]
56. Deng Z,, Meng X,, Su S,, Liu Z,, Ji X,, Zhang Y,, Zhao X,, Wang X,, Yang R,, Han Y . 2012. Two sRNA RyhB homologs from Yersinia pestis biovar microtus expressed in vivo have differential Hfq-dependent stability. Res Microbiol 163 : 413 418.[PubMed]
57. Huang SH,, Wang CK,, Peng HL,, Wu CC,, Chen YT,, Hong YM,, Lin CT . 2012. Role of the small RNA RyhB in the Fur regulon in mediating the capsular polysaccharide biosynthesis and iron acquisition systems in Klebsiella pneumoniae. BMC Microbiol 12 : 148.[CrossRef]
58. Wilderman PJ,, Sowa NA,, FitzGerald DJ,, FitzGerald PC,, Gottesman S,, Ochsner UA,, Vasil ML . 2004. Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis. Proc Natl Acad Sci U S A 101 : 9792 9797.[PubMed]
59. Oglesby AG,, Farrow JM III,, Lee JH,, Tomaras AP,, Greenberg EP,, Pesci EC,, Vasil ML . 2008. The influence of iron on Pseudomonas aeruginosa physiology: a regulatory link between iron and quorum sensing. J Biol Chem 283 : 15558 15567.[PubMed]
60. Reinhart AA,, Powell DA,, Nguyen AT,, O’Neill M,, Djapgne L,, Wilks A,, Ernst RK,, Oglesby-Sherrouse AG . 2015. The prrF-encoded small regulatory RNAs are required for iron homeostasis and virulence of Pseudomonas aeruginosa. Infect Immun 83 : 863 875.[PubMed]
61. Reinhart AA,, Nguyen AT,, Brewer LK,, Bevere J,, Jones JW,, Kane MA,, Damron FH,, Barbier M,, Oglesby-Sherrouse AG . 2017. The Pseudomonas aeruginosa PrrF small RNAs regulate iron homeostasis during acute murine lung infection. Infect Immun 85 : e00764–16.[CrossRef]
62. Oglesby-Sherrouse AG,, Vasil ML . 2010. Characterization of a heme-regulated non-coding RNA encoded by the prrF locus of Pseudomonas aeruginosa. PLoS One 5 : e9930.[CrossRef]
63. Osborne J,, Djapgne L,, Tran BQ,, Goo YA,, Oglesby-Sherrouse AG . 2014. A method for in vivo identification of bacterial small RNA-binding proteins. MicrobiologyOpen 3 : 950 960.[PubMed]
64. Jung YS,, Kwon YM . 2008. Small RNA ArrF regulates the expression of sodB and feSII genes in Azotobacter vinelandii. Curr Microbiol 57 : 593 597.[PubMed]
65. Pyla R,, Kim TJ,, Silva JL,, Jung YS . 2010. Proteome analysis of Azotobacter vinelandii Δ arrF mutant that overproduces poly-β-hydroxybutyrate polymer. Appl Microbiol Biotechnol 88 : 1343 1354.[PubMed]
66. Mellin JR,, Goswami S,, Grogan S,, Tjaden B,, Genco CA . 2007. A novel Fur- and iron-regulated small RNA, NrrF, is required for indirect Fur-mediated regulation of the sdhA and sdhC genes in Neisseria meningitidis. J Bacteriol 189 : 3686 3694.[PubMed]
67. Pannekoek Y,, Huis In ’t Veld R,, Schipper K,, Bovenkerk S,, Kramer G,, Speijer D,, van der Ende A . 2017. Regulation of Neisseria meningitidis cytochrome bc 1 components by NrrF, a Fur-controlled small noncoding RNA. FEBS Open Bio 7 : 1302 1315.[PubMed]
68. Mellin JR,, McClure R,, Lopez D,, Green O,, Reinhard B,, Genco C . 2010. Role of Hfq in iron-dependent and -independent gene regulation in Neisseria meningitidis. Microbiology 156 : 2316 2326.[PubMed]
69. Metruccio MM,, Fantappiè L,, Serruto D,, Muzzi A,, Roncarati D,, Donati C,, Scarlato V,, Delany I . 2009. The Hfq-dependent small noncoding RNA NrrF directly mediates Fur-dependent positive regulation of succinate dehydrogenase in Neisseria meningitidis. J Bacteriol 191 : 1330 1342.[PubMed]
70. Ducey TF,, Jackson L,, Orvis J,, Dyer DW . 2009. Transcript analysis of nrrF, a Fur repressed sRNA of Neisseria gonorrhoeae. Microb Pathog 46 : 166 170.[PubMed]
71. Gaballa A,, Antelmann H,, Aguilar C,, Khakh SK,, Song KB,, Smaldone GT,, Helmann JD . 2008. The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins. Proc Natl Acad Sci U S A 105 : 11927 11932.[PubMed]
72. Smaldone GT,, Antelmann H,, Gaballa A,, Helmann JD . 2012. The FsrA sRNA and FbpB protein mediate the iron-dependent induction of the Bacillus subtilis lutABC iron-sulfur-containing oxidases. J Bacteriol 194 : 2586 2593.[PubMed]
73. Georg J,, Kostova G,, Vuorijoki L,, Schön V,, Kadowaki T,, Huokko T,, Baumgartner D,, Müller M,, Klähn S,, Allahverdiyeva Y,, Hihara Y,, Futschik ME,, Aro EM,, Hess WR . 2017. Acclimation of oxygenic photosynthesis to iron starvation is controlled by the sRNA IsaR1. Curr Biol 27 : 1425 1436.e7.[CrossRef]
74. Hernández JA,, Muro-Pastor AM,, Flores E,, Bes MT,, Peleato ML,, Fillat MF . 2006. Identification of a furA cis antisense RNA in the cyanobacterium Anabaena sp. PCC 7120. J Mol Biol 355 : 325 334.[PubMed]
75. Hernández JA,, Alonso I,, Pellicer S,, Luisa Peleato M,, Cases R,, Strasser RJ,, Barja F,, Fillat MF . 2010. Mutants of Anabaena sp. PCC 7120 lacking alr1690 and α- furA antisense RNA show a pleiotropic phenotype and altered photosynthetic machinery. J Plant Physiol 167 : 430 437.[PubMed]
76. Gnandt E,, Dörner K,, Strampraad MF,, de Vries S,, Friedrich T . 2016. The multitude of iron-sulfur clusters in respiratory complex I. Biochim Biophys Acta 1857 : 1068 1072.[PubMed]
77. Li GW,, Burkhardt D,, Gross C,, Weissman JS . 2014. Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. Cell 157 : 624 635.[PubMed]
78. Arias-Cartin R,, Grimaldi S,, Pommier J,, Lanciano P,, Schaefer C,, Arnoux P,, Giordano G,, Guigliarelli B,, Magalon A . 2011. Cardiolipin-based respiratory complex activation in bacteria. Proc Natl Acad Sci U S A 108 : 7781 7786.[PubMed]
79. Beauchene NA,, Mettert EL,, Moore LJ,, Keleş S,, Willey ER,, Kiley PJ . 2017. O 2 availability impacts iron homeostasis in Escherichia coli. Proc Natl Acad Sci U S A 114 : 12261 12266.[PubMed]
80. Guillier M,, Gottesman S . 2006. Remodelling of the Escherichia coli outer membrane by two small regulatory RNAs. Mol Microbiol 59 : 231 247.[PubMed]
81. Guillier M,, Gottesman S . 2008. The 5′ end of two redundant sRNAs is involved in the regulation of multiple targets, including their own regulator. Nucleic Acids Res 36 : 6781 6794.[PubMed]
82. Boysen A,, Møller-Jensen J,, Kallipolitis B,, Valentin-Hansen P,, Overgaard M . 2010. Translational regulation of gene expression by an anaerobically induced small non-coding RNA in Escherichia coli. J Biol Chem 285 : 10690 10702.[PubMed]
83. Durand S,, Storz G . 2010. Reprogramming of anaerobic metabolism by the FnrS small RNA. Mol Microbiol 75 : 1215 1231.[PubMed]
84. Benjamin JA,, Massé E . 2014. The iron-sensing aconitase B binds its own mRNA to prevent sRNA-induced mRNA cleavage. Nucleic Acids Res 42 : 10023 10036.[PubMed]
85. Li F,, Wang Y,, Gong K,, Wang Q,, Liang Q,, Qi Q . 2014. Constitutive expression of RyhB regulates the heme biosynthesis pathway and increases the 5-aminolevulinic acid accumulation in Escherichia coli. FEMS Microbiol Lett 350 : 209 215.[PubMed]
86. Tanabe T,, Funahashi T,, Nakao H,, Maki J,, Yamamoto S . 2013. The Vibrio parahaemolyticus small RNA RyhB promotes production of the siderophore vibrioferrin by stabilizing the polycistronic mRNA. J Bacteriol 195 : 3692 3703.[PubMed]


Generic image for table
Table 1

Summary of validated and putative RyhB targets using different set of data

Citation: Chareyre S, Mandin P. 2019. Bacterial Iron Homeostasis Regulation by sRNAs, p 267-281. In Storz G, Papenfort K (ed), Regulating with RNA in Bacteria and Archaea. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.RWR-0010-2017
Generic image for table
Table 2

Overview of Fe-sparing response by sRNA in bacteria

Citation: Chareyre S, Mandin P. 2019. Bacterial Iron Homeostasis Regulation by sRNAs, p 267-281. In Storz G, Papenfort K (ed), Regulating with RNA in Bacteria and Archaea. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.RWR-0010-2017

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error