Chapter 21 : Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target

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Antibiotic resistance is a great and growing threat to public health, motivating scientists to find innovative strategies to cure infections ( ). An alternative approach to classical antibiotics is to target virulence factors ( ): bacterial factors required for infection or damage but not for growth outside the host ( ). An antivirulence factor should render the bacteria nonpathogenic by neutralizing a critical virulence element, thereby allowing clearance of the pathogen by the host immune system ( ).

Citation: Fasciano A, Shaban L, Mecsas J. 2019. Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target, p 261-276. In Sandkvist M, Cascales E, Christie P (ed), Protein Secretion in Bacteria. ASM Press, Washington, DC. doi: 10.1128/ecosalplus.ESP-0032-2018
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Figure 1

Asterisks indicate regions with conserved components between T3SSi and flagella. Orange, ; blue, ; purple, EPEC/EHEC; green, ; red, . Potential targets of compounds based on inhibition of T3SSi function, biochemical or binding studies, genetic resistance, or animal studies.

Citation: Fasciano A, Shaban L, Mecsas J. 2019. Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target, p 261-276. In Sandkvist M, Cascales E, Christie P (ed), Protein Secretion in Bacteria. ASM Press, Washington, DC. doi: 10.1128/ecosalplus.ESP-0032-2018
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Table 1

Possible targets and function of small-molecule inhibitors of the T3SS

Citation: Fasciano A, Shaban L, Mecsas J. 2019. Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target, p 261-276. In Sandkvist M, Cascales E, Christie P (ed), Protein Secretion in Bacteria. ASM Press, Washington, DC. doi: 10.1128/ecosalplus.ESP-0032-2018
Generic image for table
Table 2

Antibodies, vaccines, and peptomers against T3SS components

Citation: Fasciano A, Shaban L, Mecsas J. 2019. Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target, p 261-276. In Sandkvist M, Cascales E, Christie P (ed), Protein Secretion in Bacteria. ASM Press, Washington, DC. doi: 10.1128/ecosalplus.ESP-0032-2018

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