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Category: Bacterial Pathogenesis
Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781683670285/9781683670278_Chap21-1.gif /docserver/preview/fulltext/10.1128/9781683670285/9781683670278_Chap21-2.gifAbstract:
Antibiotic resistance is a great and growing threat to public health, motivating scientists to find innovative strategies to cure infections ( 1 – 3 ). An alternative approach to classical antibiotics is to target virulence factors ( 4 ): bacterial factors required for infection or damage but not for growth outside the host ( 2 , 5 , 6 ). An antivirulence factor should render the bacteria nonpathogenic by neutralizing a critical virulence element, thereby allowing clearance of the pathogen by the host immune system ( 5 – 8 ).
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Structure of T3SSi.(A) Asterisks indicate regions with conserved components between T3SSi and flagella. Orange, Yersinia; blue, Pseudomonas; purple, EPEC/EHEC; green, Salmonella; red, Shigella. (B) Potential targets of compounds based on inhibition of T3SSi function, biochemical or binding studies, genetic resistance, or animal studies.
Possible targets and function of small-molecule inhibitors of the T3SS a
Antibodies, vaccines, and peptomers against T3SS components a