Books
Search, browse, and discover hundreds of books that ASM publishes by internationally renowned authors and editors with expertise in a broad range of microbiology disciplines. Here you can purchase print or ebooks: print books are shipped (added shipping charges) and ebooks are downloadable files, in your choice of either ePub or PDF. You can also buy downloadable books by the chapter. Note that you have 48 hours to download your purchase from this site, after which access ends. Ebook/echapter purchases are final and nonrefundable.
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Accessing Uncultivated Microorganisms : From the Environment to Organisms and Genomes and Back
- Content Type: Monograph
- Editor: Karsten Zengler
- Publication Year: 2008
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Abstract:
Microbes are extremely diverse, yet only a tiny fraction of organisms present in any given environment can be cultivated in the laboratory. Evaluating microbial diversity and identifying individual organisms responsible for specific processes in the environment are fundamental and challenging tasks in microbial ecology and applied microbiology. This comprehensive, judicious, and useful volume provides a complete overview of methods and approaches to studying microbial diversity. While emphasizing new innovative methods, the book also addresses established methods and provides “hands on” advice on how to isolate, cultivate, and study organisms.
Depending on the scope of a study, there are many different ways to assess the diversity of bacteria, fungi, and protists. This volume examines the variety of these approaches-and their advantages and drawbacks. From direct measurements of physical, chemical, and biological aspects of the environment to a wide array of molecular tools such as metagenomic and metaproteomic approaches, this volume thoroughly covers the range of assessment possibilities. It also details innovative methods such as the use of genetic information from environmental samples, enrichment cultures, and single cells. Additionally, the book offers practical, essential advice on how to put these methods into practice both within and outside of the laboratory environment.
Electronic Only, 308 pages, illustrations, index.
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Animalcules : The Activities, Impacts, and Investigators of Microbes
- Content Type: Trade
- Author: Bernard Dixon
- Publication Year: 2009
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Abstract:
An entertaining and informative overview on microbiology and its heroes, dissenters, and discoveries
Begun three centuries ago by pioneers who constructed rudimentary microscopes to observe otherwise invisible life, the field of microbiology has often evolved in unexpected ways. Through the techniques introduced by these first luminaries, our knowledge of what Leeuwenhoek called animalcules has deepened considerably. So too has our awareness of our paradoxical relationship with the microbial world. Microorganisms continually assail our tissues, yet they also provide the means of promoting human health and environmental well-being. This entertaining and informative volume provides a broad picture of the most compelling areas of the field, its early history, and its recent discoveries.
Animalcules presents a collection of the columns of the same name that have been published over the course of the past 12 years in Microbe (formerly ASM News). This volume is an erudite, yet approachable overview of microbiology. It introduces the field’s earliest “microbe hunters” in their human context. By chronicling the history, pioneers, and discoveries of microbiology, Animalcules provides an important window into the incredible diversity of the microbial world. It covers the pioneering work of early scientists like Antony van Leeuwenhoek, Robert Hooke, and Hideyo Noguchi while also providing thoughtful explanations on timely topics such as Botox, Lyme disease, and bioremediation.
Hardcover, 343 pages, index.
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Antibiogram
- Content Type: Monograph
- Editors: Patrice Courvalin, Roland LeClercq, Louis B. Rice
- Publication Year: 2010
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Antibiogram is the first English edition of the original French work published in 1985. Over the last twenty years, new categories of antibiotics have entered the market and numerous forms of resistance have appeared and multiplied. The revised volume comprehensively incorporates all of the major developments that have occurred in the field since the publication of the first edition.
The book is comprised of four sections: the antibiogram principles and methods, the antibiogram of the principal bacterial groups, technical specifications for antibiotics case studies, and appendixes and definitions.
With contributions made by more than fifty authors, this new volume is intended primarily for bacteriologists and biologists working in laboratory settings, for infectious disease specialists, for researchers in the pharmaceutical industry, and also for students.
Key Features
- Provides a comprehensive compendium for antibiotherapy
- Includes many chapters offering expanded coverage of new categories of antibiotics
- Offers numerous illustrations to help the reader easily understand the topics discussed
- Features contributions by more than fifty international experts working in the field
- Presents appendixes that include everything from definitions and acronyms to information on industry web sites and literature
Hardcover, 705 pages, full-color insert, illustrations, index.
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Antibiotics : Actions, Origins, Resistance
- Content Type: Monograph
- Author: Christopher Walsh
- Publication Year: 2003
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This new text offers a comprehensive, up to date account of those structural classes of antibiotics that have had an impact in human infectious disease. While most of the attention is on natural products with antibiotic activity elaborated by microbes to act as chemical weapons on neighboring bacteria, synthetic chemicals with antibiotic activity are also discussed.
The book opens with an introduction to antibiotics, followed by a section that examines how antibiotics block specific proteins acting in these essential bacterial processes and how the molecular structure of the small-molecule drugs enables their antibiotic activity. Section III explores the development of bacterial resistance to antibiotics, including the molecular logic that microbial producers of antibiotics use for self-protection. The fourth section addresses the molecular logic of antibiotic biosynthesis, starting with regulatory networks that control gene transcription of secondary metabolites in streptomycetes. The final section examines the prospects for broadening the base of bacterial targets and also where new antibiotics are likely to emerge, including both synthetic chemical efforts and natural products.
Out of Print, paperback, 335 pages, illustrations, index.
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Antibiotics: Challenges, Mechanisms, Opportunities
- Content Type: Textbook
- Editors: Christopher Walsh, Timothy Wencewicz
- Publication Year: 2016
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Antibiotics: Challenges, Mechanisms, Opportunities is now available on Wiley.comMembers, use the code ASM20 at check out to receive your 20% discount.
Help your students save on textbooks! Email us and receive a coupon to share with your students for 20% off of the purchase of a print copy.
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sourcFes. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.
This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.
Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:
- What are antibiotics?
- Where do antibiotics come from?
- How do antibiotics work?
- Why do antibiotics stop working?
- How should our limited inventory of effective antibiotics be addressed?
Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
“This book provides all the information needed to understand antibiotic genetics, biochemistry, mechanism of action and resistance. Most importantly, Walsh and Wencewicz are optimistic of the prospects of the discovery of novel therapeutic agents obtained by the manipulation of strains and biosynthetic pathways. This beautifully written book deserves to be read and implemented by everyone, especially the pessimists who believe that the antibiotic era has ended. In Antibiotics: Challenges, Mechanisms, Opportunities, Walsh and Wencewicz provide the definitive, ultimate compendium of everything antibiotic.”
— Julian Davies, Professor of Microbiology and Immunology, Life Sciences Institute, University of British Columbia Vancouver
Hardcover, 477 pages, full-color illustrations, index.
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Antibodies for Infectious Diseases
- Content Type: Monograph
- Editors: James E. Crowe, Diana Boraschi, Rino Rappuoli
- Publication Year: 2015
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Antibodies for Infectious Diseases is now available on Wiley.comMembers, use the code ASM20 at check out to receive your 20% discount.State-of-the-art reviews covering major aspects of antibodies and intervention against infectious diseases.
The connection between antibodies and infectious diseases has spawned entire related fields of study. Antibodies for Infectious Diseases presents perspectives from leading research scientists and summarizes the amazing progress in this area into a single definitive source.
Providing a broad survey of the most important aspects of the field of antibodies for infectious diseases, this book
- presents general features pertaining to structure, function, isotype, and the role of complement in antibody function
- examines the role of antibodies in antimicrobial immunity with specific targets
- details new methods for expression of monoclonal antibodies, in plants or by transfer of antibody genes for in vivo expression in treated subjects
Antibodies for Infectious Diseases is a comprehensive reference for researchers, pharmaceutical developers, and health care professionals on the status of the development of antibody-based therapies for treating infectious diseases. It is also useful as supplemental reading for upper level life sciences students.
James E. Crowe, Jr. is an immunologist and board-certified pediatric infectious diseases specialist. Dr. Crowe is the Ann Scott Carell Chair and Professor of Pediatrics, Pathology, Microbiology and Immunology, and Director of the Vanderbilt Vaccine Center. He is an Elected Member of the Institute of Medicine and a Fellow of the American Association for the Advancement of Science, the American Academy of Microbiology, and the American Society for Clinical Investigation. Dr. Crowe’s laboratory has a broad portfolio of work in the area of viral immunology and cell biology focused on discovery of the genetic and structural determinants of neutralization of viruses by human antibodies and immune mechanisms important to development of new vaccines.
Diana Boraschi is the Research Director at the CNR Institute of Protein Biochemistry. She is actively involved in high education activities, in particular in Africa. Dr. Boraschi’s studies focus on the role of macrophages and IL-1 cytokines in the innate/inflammatory response against infections and tumors and their possible involvement in chronic inflammatory and autoimmune pathologies.
Rino Rappuoli is the Global Head of Research and Development at Novartis Vaccines. Dr. Rappuoli has worked on several molecules that became part of, or are near to becoming, licensed vaccines. He is an elected member of the U.S. National Academy of Sciences and of the European Molecular Biology Organization.
Hardcover, 457 pages, full-color illustrations, index.
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Antimicrobial Agents : Antibacterials and Antifungals
- Content Type: Reference
- Editor: André Bryskier, M.D.
- Publication Year: 2005
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Antimicrobial Agents: Antibacterials and Antifungals is a significant revision of an original French reference published by Ellipses in 1999. Featuring more than 1,200 illustrations, over 1,500 tables, and more than 3,000 references, this major new volume comprehensively covers the history, chemistry, synthesis, mechanisms of action, pharmacology, and efficacy of all antimicrobial agents.
Written by experts, Antimicrobial Agents opens with foundational material covering the history of antibacterial chemotherapy, the system of classifying antimicrobial agents, the epidemiology of resistance, and the development of an antibiotic. The body of the text is divided into antimicrobial classes, including new chapters that extensively cover Helicobacter pylori and methicillin-resistant Staphylococcus aureus. Also examined are antimicrobial agents that are in advanced states of development, products that are used on animals, agents that are as yet unexplored, and those for which development has ceased. All existing chapters have been thoroughly updated to reflect advances in technology and research since the publication of the first edition.
Unmatched in depth and scope of coverage, the new edition of Antimicrobial Agents: Antibacterials and Antifungals is the reference source for physicians, microbiologists, chemists, pharmacologists, research scientists, and all others involved in antimicrobial research and development.
Hardcover, 1,426 pages, illustrations, index.
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Antimicrobial Resistance in Bacteria from Livestock and Companion Animals
- Content Type: Monograph
- Editors: Stefan Schwarz, Lina Maria Cavaco, Jianzhong Shen
- Publication Year: 2018
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Abstract:
Antimicrobial Resistance in Bacteria from Livestock and Companion Animals is now available on Wiley.comMembers, use the code ASM20 at check out to receive your 20% discount.
The global spread of antimicrobial-resistant pathogenic bacteria is a continuing challenge to the health care of humans and domesticated animals. With no new agents on the horizon, it is imperative to use antimicrobial agents wisely to preserve their future efficacy.
An international team of experts in antimicrobial resistance of livestock and companion animals has created this valuable and comprehensive reference book, which includes among others:
- general aspects of antimicrobial resistance and the multiple mechanisms by which bacteria become resistant to antimicrobial agents
- resistance to metals used in livestock production and biocides that can coselect for antimicrobial resistance in bacteria
- antimicrobial resistance in specific groups of bacteria that are obligate or facultative pathogens in livestock and companion animals
- antimicrobial resistance in a One Health perspective
- risk assessment and source attribution models
- forward-looking perspectives on antimicrobial stewardship in veterinary medicine
This book is a “must-have” for veterinary students, practitioners, and microbiologists in academia, clinic and industry, but also for researchers and decision makers interested in understanding and preventing antimicrobial resistance.
Hardcover, 712 pages, full-color illustrations, index.
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Antimicrobial Resistance in Bacteria of Animal Origin
- Content Type: Monograph
- Editor: Frank M. Aarestrup
- Publication Year: 2006
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Abstract:
Antimicrobial Resistance in Bacteria of Animal Origin comprehensively examines the current research on antimicrobial resistance in the main veterinary and zoonotic pathogens, including resistance to disinfectants and metals used in agriculture. Providing a broad overview from a global perspective, this new volume is an important reference for students, researchers, public health experts, veterinarians, and anyone with an interest in resistant bacteria in animals.
Written by experts in the field of antimicrobial resistance, the early chapters provide information on modes of action of antibiotics and mechanisms of bacterial resistance, in addition to exploring the history of antimicrobial use in agriculture. Several chapters are devoted to examination of antimicrobial resistance in specific bacteria, including: the family Pasteurellaceae, species of Campylobacter, pathogenic Escherichia coli, staphylococci, steptococci, and Enterococcus. Also detailed are phenotypic and molecular methods for susceptibility testing, regulatory mechanisms for usage of antibiotics, and methods for monitoring drug usage and resistance.
Electronic Only, 441 pages, illustrations, index.
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Antisepsis, Disinfection, and Sterilization : Types, Action, and Resistance
- Content Type: Monograph
- Author: Gerald E. McDonnell
- Publication Year: 2007
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Abstract:
The new title examines the various chemical and physical antisepsis, disinfection, and sterilization methods used for infection prevention and contamination control. Targeting microbiologists, chemists, facilities managers, health care professionals, infection and contamination control practitioners, application engineers, and students, Antisepsis, Disinfection, and Sterilization is a valuable reference written by an acknowledged expert working in the field.
The book provides descriptive background material covering the applications and various chemical and physical processes used for microbial control. An array of biocides is described, and the variables affecting their safe and effective use are detailed. The advantages, disadvantages, limitations, and correct applications of biocides and biocidal processes are discussed as well.
The mechanisms of biocidal action on microorganisms are investigated, including an examination of the less-studied intrinsic and acquired mechanisms of resistance in viruses, prions, protozoa, and fungi. Further considerations are given to the mechanisms on intrinsic and acquired resistance to biocides and biocidal processes, including cross-resistance to antibiotics in bacteria and novel mechanisms in extremophiles.
Digital Only, 361 pages, illustrations, index.
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Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance, Second Edition
- Content Type: Monograph
- Author: Gerald E. McDonnell
- Publication Year: 2017
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Abstract:
Antisepsis, Disinfection, and Sterilization is now available on Wiley.comMembers, use the code ASM20 at check out to receive your 20% discount.
The theory and practice of controlling and eliminating microorganisms
Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance, by Gerald E. McDonnell, is a detailed and accessible presentation of the current methods of microbial control. Each major category, such as physical disinfection methods, is given a chapter, in which theory, spectrum of activity, advantages, disadvantages, and modes of action of the methods are thoroughly and clearly presented. Sufficient background on the life cycles and general anatomy of microorganisms is provided so that the reader who is new to microbiology will better appreciate how physical and chemical biocides work their magic on microbes. Other topics in the book include:
- Evaluating the efficacy of chemical antiseptics and disinfectants, and of physical methods of microbial control and sterilization.
- Understanding how to choose the proper biocidal product and process for specific applications.
- Classic physical and chemical disinfection methods, such as heat, cold, non-ionizing radiation, acids, oxidizing agents, and metals.
- Newer chemical disinfectants, including, isothiazolones, micro-and nano-particles, and bacteriophages as control agents.
- Antisepsis of skin and wounds and the biocides that can be used as antiseptics.
- Classic methods of physical sterilization, such as, moist heat and dry heat sterilization, ionizing radiation, and filtration, along with newer methods, including, the use of plasma or pulsed light.
- Chemical sterilization methods that use ethylene oxide, formaldehyde, or a variety of other oxidizing agents.
- A detailed look at the modes of action of biocides in controlling microbial growth and disrupting microbial physiology.
- Mechanisms that microorganisms use to resist the effects of biocides.
The second edition of Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance is well suited as a textbook and is outstanding as a reference book for facilities managers and application engineers in manufacturing plants, hospitals, and food production facilities. It is also essential for public health officials, healthcare professionals, and infection control practitioners.
Hardcover, 432 pages, full-color illustrations, index.
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Antiviral Research : Strategies in Antiviral Drug Discovery
- Content Type: Monograph
- Editor: Robert L. LaFemina, Ph. D.
- Publication Year: 2009
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Abstract:
This book captures the state of the science with twenty reviews that examine the latest in today’s antiviral drug discovery efforts. The introduction of nucleoside analogs and investigations of novel antiviral targets have brought significant new possibilities to the field. These reviews range from in-depth analyses of a specific viral target, to examination of multiple targets in medically important viruses. All chapters include the authors’ thoughts regarding future developments in their specific topic, and the book concludes with an Afterword in which several experts consider the general future of antiviral drug discovery.
With its coverage of many different types of viruses including influenza virus, herpesvirus, the SARS coronavirus, orthopox- and flaviviruses, hepatitis C virus, and a wide range of topics in HIV-1, Antiviral Research offers investigators a broad view of the current state of nucleoside analogs and other antiviral strategies. This book is certain to help stimulate new ideas and approaches for virologists, biochemists, pharmaceutical chemists, and other investigators.
Electronic Only, 373 pages, full-color insert, illustrations, index.
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Archaea : Molecular and Cellular Biology
- Content Type: Monograph
- Editor: Ricardo Cavicchioli
- Publication Year: 2007
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Abstract:
Since the discovery in 1977 that they constitute a distinct branch of the biological world, archaea have expanded and altered the field of microbiology. Archaea can thrive in some of the most extreme environments of the planet, from extremely alkaline or acid waters to high-temperature environments near thermal vents in the deep sea. This exceptional ability to survive and prosper has led scientists to speculate that archaea played a significant role in shaping all life on Earth and may provide valuable keys to the search for extra-terrestrial life.
This path-breaking book fully describes the molecular cell biology of the archaea in one accessible and readable volume. With twenty-three chapters by the world’s leading experts, this book emphasizes each author’s individual research expertise, while also being a general guide to the latest knowledge on archaea. The core of the book describes the key cellular processes such as DNA replication, transcription, translation, lipids and metabolism. It also explains their unique features including aminoacyl-tRNA synthesis, signal transduction, and post-translational modification. Above all, this volume details the latest discoveries of the twenty-first century and anticipates new progress expected in the future.
This volume is a timely and essential reference for researchers, instructors, practitioners in the field, and students of the unique qualities of Archaea. Archaea: Cellular and Molecular Biology will remain the authoritative reference source for the many disciplines interested in the archaea for years to come.
Hardcover, 523 pages, full-color insert, illustrations, index.
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Aspergillus fumigatus and Aspergillosis
- Content Type: Monograph
- Editors: Jean-Paul Latgé, William J. Steinbach
- Publication Year: 2009
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Abstract:
Modern medical technologies are repairing the human body in ways never imagined only a few years ago, but they are leaving an increasing population of patients who are newly susceptible to opportunistic pathogens. Invasive and chronic fungal infections have become a formidable clinical opponent, and foremost among them is Aspergillus fumigatus.
Aspergillusfumigatus and Aspergillosis assembles chapters from a large and international contingent of experts in the field to explore every major aspect of A. fumigatus and how it kills so many patients. This volume offers the latest insights into the fundamental biology and pathogenesis of A. fumigatus and how it establishes disease, as well as the newest strategies for characterizing, diagnosing, and treating its spectrum of clinical infection.
This valuable book is an instrumental resource for both scientists and clinicians tackling the current problems with Aspergillosis. It presents chapters on the species itself, including morphology and unique and specific genes, the importance of polarized growth, as well as the organism’s response to environmental stress by moving from a saprophyte to a pathogen. The interface with the host immune system-paramount to disease phenotype-is detailed, as are the many faces of disease created by A. fumigatus. Newer diagnostic and treatment strategies are covered, including the optimal timing of antifungal therapy and the strategic choice of which agent to use.
Hardcover, 568 pages, full-color insert, illustrations, index.
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Bacillus subtilis and Its Closest Relatives : from Genes to Cells
- Content Type: Monograph
- Editors: Abraham L. Sonenshein, Richard Losick, James A. Hoch
- Publication Year: 2002
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Bacillus subtilis has become the principle paradigm for analysis of the physiology of gram-positive bacteria, bacterial differentiation, and useful applications of bacterial products. Sequencing of whole bacterial genomes and the experimental approaches made possible by accessibility to the sequences have brought a new perspective to microbiology.
Focusing on issues of gene organization, regulation, and evolution in the context of the whole life of the cell, this new volume complements the editors' classic 1993 volume Bacillus subtilis and Other Gram-Positive Bacteria. Building upon the previous edition, Bacillus subtilis and Its Closest Relatives contains an updated annotation of the complete B. subtilis genome and includes a unique compilation of major pathways of metabolism and macromolecular synthesis, correlating genes and proteins and assigning new functions to many genes. It also provides clear explanations of the major regulatory mechanisms that are unique to gram-positive bacteria as well as an overview of their special properties.
This essential reference offers detailed, current information and is valuable reading for microbiologists, biotechnologists, and students.
Electronic only, 629 pages, illustrations, color insert, index.
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Bacillus subtilis and Other Gram-Positive Bacteria : Biochemistry, Physiology, and Molecular Genetics
- Content Type: Monograph
- Editors: Abraham L. Sonenshein, James A. Hoch, Richard Losick
- Publication Year: 1993
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Brings together world experts and their research on the architecture, biochemical pathways, genetic organization, and gene regulation of Bacillus subtillis. Offers tables and figures along with chapters that serve as very accessible references for essential facts. Reflects the recent and rapid advances in studying gram-positive bacteria and makes useful comparisons among diverse groups of microorganisms. Serves as the major point of reference for this field.
Electronic Only, 1002 pages, illustrations, index.
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Bacteria and Intracellularity
- Content Type: Monograph
- Editors: Pascale Cossart, Craig R. Roy, Philippe Sansonetti
- Publication Year: 2019
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Bacteria and Intracellularity is now available on Wiley.comMembers, use the code ASM20 at check out to receive your 20% discount.
Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host–bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria.
This book offers a wide-ranging look at the latest studies, including
- foodborne pathogens and the study of how, when, and where bacteria interact with the gut and its microbiota
- infections of the urogenital tract, endothelial barriers, and the nervous system
- major advances in work with Mycobacterium tuberculosis and M. leprae
- subcellular microbiology, including metabolism of infected cells, nuclear biology, and microRNAs
- endosymbionts, in particular the latest work with Wolbachia and its effect on insect transmission of viral pathogens
- research into cell autonomous defense pathways that has led to major insights into immunology and innate immunity
- the latest developments in technology, for the next steps in the study of intracellularity
All facets of cellular physiology, within the entire scope of cells and host tissues, can be targeted by pathogens. Bacteria and Intracellularity offers to researchers, students, and laboratorians a valuable overview of the state of current research into the cellular microbiology of host-pathogen interactions.
Hardcover, 356 pages, full-color illustrations, index.
To purchase the print version of this title, please go to: https://www.wiley.com/en-us/Bacteria+and+Intracellularity-p-9781683670254
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Bacteria versus Antibacterial Agents : an Integrated Approach
- Content Type: Textbook
- Author: Oreste A. Mascaretti
- Publication Year: 2003
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Abstract:
Help your students save on textbooks! Email us and receive a coupon to share with your students for 20% off of the purchase of a print copy.
Designed as an introductory text on antibacterial agents, this new volume provides a clear, comprehensive and concise overview of the subject, including the most recent and significant developments in antibacterial agents with novel modes of action.
The basics of bacterial structure and function are reviewed, describing the basis for understanding mechanisms of antibacterial action, as well as the mechanisms developed by bacteria to overcome the action of antibacterial agents. The volume also covers the characteristic features of bacterial pathogenicity, the genetic basis of resistance to antibacterial drugs, the biochemical mechanisms of action of antibacterial drugs, how antibacterial drugs reach their targets in gram-positive and gram-negative bacteria, and the wide range of human immune responses against bacterial infections.
Recent advances in research and development of new classes of antibacterial drugs are examined, as are improved analogs of penicillin, cephalosporins, carbapenems, aminoglyosides, tetracyclines, etc.
Hardcover, 393 pages, illustrations, index.
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Bacterial Adhesion to Animal Cells and Tissues
- Content Type: Monograph
- Authors: Itzhak Ofek, David L. Hasty, Ron J. Doyle
- Publication Year: 2003
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Abstract:
The adhesion of bacteria to host cells is a critical event in the development of bacterial infections. Knowledge of the molecular mechanisms of this process is key to understanding an essential step in pathogenesis and to identifying potential targets for antimicrobial therapy.
This authoritative volume covers historical perspectives, general principles, methodologies, specific host cell and bacterial components associated with the process, including post-adhesion consequences, regulation of adhesion expression, and anti-adhesion therapy. The final chapter compiles, primarily in tabular format, a list of all the pathogenic bacterial species that were tested over the past ten years for their ability to adhere, the test substrata that were used, as well as the adhesions involved in the cases where they are known.
Bacterial Adhesion to Animal Cells and Tissues is an essential reference for students and investigators interested in host-pathogen interactions.
Electronic Only, 416 pages, illustrations, index.
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The Bacterial Chromosome
- Content Type: Monograph
- Editor: N. Patrick Higgins
- Publication Year: 2005
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Abstract:
The Bacterial Chromosome is a state-of-the art examination of the mechanisms governing genetic inheritance, a timely update to the 1990 publication of the same name. Advances in evolutionary theory have been stimulated by the availability of complete bacterial sequences, while recent biochemical research has revealed how protein machines control chromosome function.
Incorporating section overviews provided by eminent geneticists and biochemists, the book provides a link between classical experiments in chromosome physiology and new developments in genetic research. From the first section, “Genetic and Physical Structure,” to the last, “Nonhomologous Recombination,” The Bacterial Chromosome comprehensively covers the fundamental systems required for all bacterial cells to replicate chromosomes and organize genetic information. Complex biochemical reactions, including DNA replication, genetic recombination, and RNA transcription, are presented from both genetic and physical perspectives. The implications of the DNA sequence database are incorporated with information on horizontal gene transfer and the impact of phage genes on bacterial genomes.
Hardcover, 559 pages, full-color insert, illustrations, index.