Antibody-Producing Cells
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- Chapter [2] http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://pub2web.metastore.ingenta.com/ns/Chapter
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- 2009 [1] http://pub2web.metastore.ingenta.com/ns/yearOfPublication 2009
2 results
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The Immunity Alphabet
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Source: The Elusive Malaria Vaccine , pp 49-75
Publication Date :
January 2009
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Abstract:
The goal of developing a vaccine targeted at the blood stage of the malaria parasite is to mimic that same condition in infants and young children so that they too may enjoy lifelong immunity with natural boosting by exposure to the blood-sucking, parasite-carrying Anopheles. To “read” the immune system, it would be essential to know its “alphabet”—the building blocks of comprehension. Over the past century, much has been learned about the alphabet of immunity; through investigation, reading, and comprehension, it has provided grist for the mills of vaccine producers (vaccinologists) who are searching for protection against a wide variety of potential assassins, including malaria parasites. This chapter discusses the immunity alphabet such as A for antibody, G for globulin, I for the immune system, N for natural immunity, B for B lymphocytes, and C for cell-mediated immunity. It is hoped that the more we know about the immune responses to a natural malaria infection, as well as the more we understand about the character of the immune systems themselves, the better able we will be to develop a protective malaria vaccine.
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Cells of the Immune System
- Author: Elinor M. Levy
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Source: Immunology, Infection, and Immunity , pp 47-66
Publication Date :
January 2004
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Abstract:
The cells of the immune system include the granulocytes (neutrophils, eosinophils, and basophils), mast cells, monocytes, dendritic cells, lymphocytes, and platelets. This chapter covers growth and development of immune cell types; identification of cell types by cell surface markers; morphology and immune function of myeloid cell types; morphology and immune function of lymphoid cell types. In adults, hematopoiesis normally takes place in the bone marrow. Neutrophils are the most numerous leukocytes in the blood and the most important cellular component of the innate immune system for destroying bacteria and fungi via phagocytosis. As such, neutrophils are a major first line of defense against such infections. Lymphoid cells are morphologically the simplest and functionally the most diverse cells of the immune system. In summary, lymphoid cell surface markers can be used to provide not only information about a lymphocyte's lineage but also specific information about a lymphocyte's maturation and activational state. Natural killer (NK) cells are part of the innate immune system and are able to act rapidly, within several hours of challenge.