Microbe Magazine

Cover ImageVaccines are crucial for controlling the spread of influenza, but currently are only effective against a limited mix of strains. A universal vaccine remains elusive, but progress is being made (see p. 433). (Image © James King-Holmes/ Science Source.)

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Microbe Magazine, Cover Image

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Living Machines: Some Assembly Required

Author: Natalie Kuldell

If you were a new student arriving at Massachusetts Institute of Technology (MIT) in Cambridge during the early 1970s with an expressed interest in mechanical engineering, you would have been advised to enroll in a class called “Introduction to Design.” Students in this class were provided compon... More...

New Approaches to Combating Tree Diseases

Author: Melanie D. G. Kaplan

Tree diseases, caused by microbial pathogens many of which are carried by insect vectors, are spreading faster than ever. “Trees didn't evolve to be able to handle the sort of things we're throwing at them,” says Adam Costanza, president of the Institute of Forest Biotechnology (IFB) in... More...

One Health through the Eyes of Clinical and Public Health Microbiology

Authors: J. Michael Miller, and Patricia M. Griffin

Clinical and public health microbiologists have long collaborated when responding to infectious disease problems to identify microbial pathogens. These investigative efforts include veterinary and environmental laboratory colleagues, taking advantage of their special skills in these arenas. These... More...

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Moth Virus Changes Host Behavior to Suit Parasitic Demands

Author: Marcia Stone

Viruses can manipulate the behavior of their insect hosts, according to Kelli Hoover at Pennsylvania State University (PSU) in University Park and her collaborators there and at the U.S. Department of Agriculture Forest Service (FS) facility in Delaware, Ohio. These findings provide the first sol... More...

A Peek at Antibiotic Development Strategies in University Settings

Author: Jeffrey L. Fox

Microbial genomics as a strategy for developing antimicrobial drugs “failed to deliver” in part because “we don't understand the biology,” says Eric Brown of McMaster University in Hamilton, Ontario, Canada. His strategy to overcome that impasse involves using antibiotics to “probe biology” ... More...

Advantages Seen for Wider Use of Needle-Free Vaccine Delivery

Author: Jeffrey L. Fox

The prospects for needle-free delivery of vaccines look bright, and this approach offers advantages that go beyond pain-free inoculations, according to Bruce Weniger of Vaccine and formerly of the Centers for Disease Control and Prevention (CDC) in Atlanta, Ga. He spoke during the symposiu... More...

Chemical Compound Selectively Kills Persister Bacterial Cells

Author: David C. Holzman

Although neither antibiotics nor the compound “C10” when used alone can kill antibiotic-resistant persister bacterial cells, pairing C10 with antibiotics proves effective, according to Dae-Hyuk Kweon, of Sungkyunkwan University, South Korea, and his collaborators. “We found that [C10] woke up the... More...

Broadly Antiviral Squalamine from Sharks Blocks Host Virus Receptors

Author: Carol Potera

Squalamine, a compound from sharks that is known for its anticancer activity, also has broad-spectrum antiviral activity, according to Michael Zasloff of Georgetown University Medical Center in Washington, D.C., and his collaborators. Its mechanism of action helps to explain this versatility, he ... More...

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A Global Forum for Clinical Microbiologists and Immunologists

Authors: Margaret McFall-Ngai, and Arturo Casadevall

“Finally, one site with a variety of information needed for the day-to-day work of diagnostic microbiologists and immunologists,” stated J. Michael Miller, Ph.D., D(ABMM). ASM's Clinical Microbiology web portal, http://clinmicro.asm.org, was launched last month under Miller's guidance.<... More...

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Important Step Towards Salmonella Vaccine

A challenge in efforts to develop a vaccine against salmonella is to detoxify salmonella lipid A while retaining its adjuvant properties for use in live attenuated vaccines for humans. Now Qingke Kong of Arizona State University, Tempe, and collaborators show that this toxicity can be reduced by ... More...

Borrelia Sequences Boost Quest for Better Lyme Diagnosis, Treatment

Sherwood Casjens of the University of Utah, Salt Lake City, et al. announce the genome sequences of Lyme disease-causing bacteria. The Borrelia species are unusual for their linear chromosomes and for carrying more plasmids than any other bacteria, and because their... More...

New Insights on Evolution, Protection from Oxy Stress in Commensal Anaerobe

Bacteroides fragilis is a strict anaerobe that comprises approximately 1 to 2% of the normal intestinal flora. While normally commensal, it is the pathogenic anaerobe most frequently isolated from intra-abdominal infections. Martin Lawrence of Montan... More...

Engineered Pyocin Prevents, Mitigates O157-induced Diarrhea in Animal Model

New therapeutics to treat Escherichia coli O157 and related Shiga toxin-producing E. coli are needed because antibiotics can augment toxin production and exacerbate the consequences of infection. Dean Scholl of AvidBioics Corp., South ... More...

First Transcriptome of Immune-Evading Toxoplasma Cysts

More than 25% of the world's population, and about 10% of Americans over age 12, are thought to be chronically infected with the protozoan parasite Toxoplasma, often due to eating undercooked or raw meat. This pathogen has two asexual stages, the rapidly growin... More...

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Microbe Magazine

FEATURES

Living Machines: Some Assembly Required

New Approaches to Combating Tree Diseases

One Health through the Eyes of Clinical and Public Health Microbiology

CURRENT TOPICS

Moth Virus Changes Host Behavior to Suit Parasitic Demands

A Peek at Antibiotic Development Strategies in University Settings

Advantages Seen for Wider Use of Needle-Free Vaccine Delivery

Chemical Compound Selectively Kills Persister Bacterial Cells

Broadly Antiviral Squalamine from Sharks Blocks Host Virus Receptors

ANIMALCULES

ASM NEWS

A Global Forum for Clinical Microbiologists and Immunologists

Education Board

International Affairs

Branches: ASM Activities at the Local Level

Membership

DEPARTMENTS

Public Affairs Report

Important Step Towards Salmonella Vaccine

Borrelia Sequences Boost Quest for Better Lyme Diagnosis, Treatment

New Insights on Evolution, Protection from Oxy Stress in Commensal Anaerobe

Engineered Pyocin Prevents, Mitigates O157-induced Diarrhea in Animal Model

First Transcriptome of Immune-Evading Toxoplasma Cysts

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Microbe Magazine

January 2012

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