Microbiology Spectrum
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In the Spring of 2021, Microbiology Spectrum will relaunch as a new open access journal that will publish research from all domains of basic, applied and clinical microbial sciences. Rather than making subjective evaluations of potential impact, Microbiology Spectrum will publish research studies that are of high technical quality and are useful to the community. All decisions will be made by an international and diverse editorial board that fully represents the microbiology research community. The journal will provide authors with fair, rapid and rigorous peer review. In addition to studies that advance our collective understanding of microbial life, the journal will also consider:
- -Replication studies that are useful to the field
- -Findings that are of primary interest to smaller sub-fields within microbiology
- -Technically robust datasets that contradict published findings
- -Negative results of interest to microbiologists
- -Descriptive datasets that would serve as a community resource
- -Methodological advances and detailed experimental protocols that are of interest to microbiologists
- -Re-analyses of large datasets that provide additional insights
- -Experimental validation screening hits from previous reports
Topics Covered: Applied and Environmental Science, Clinical Science and Epidemiology, Ecological and Evolutionary Science, Host-Microbe Biology, Molecular Biology and Physiology, Synthetic Biology, Therapeutics and Prevention
To sign up to hear more about Microbiology Spectrum CLICK HERE
Latest content:
Distinguishing Pathovars from Nonpathovars: Escherichia coli *
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Author:
Lee W. Riley
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Citation: Lee W. Riley. 2020. Distinguishing pathovars from nonpathovars: escherichia coli * . doi:10.1128/microbiolspec.AME-0014-2020
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Author: Lee W. RileyAbstract:
Escherichia coli is one of the most well-adapted and pathogenically versatile bacterial organisms. It causes a variety of human infections, including gastrointestinal illnesses and extraintestinal infections. It is also part of the intestinal commensal flora of humans and other mammals. Groups of E. coli that cause diarrhea are often described as intestinal pathogenic E. coli (IPEC), while those that cause infections outside of the gut are called extraintestinal pathogenic E. coli (ExPEC). IPEC can cause a variety of diarrheal illnesses as well as extraintestinal syndromes such as hemolytic-uremic syndrome. ExPEC cause urinary tract infections, bloodstream infection, sepsis, and neonatal meningitis. IPEC and ExPEC have thus come to be referred to as pathogenic variants of E. coli or pathovars. While IPEC can be distinguished from commensal E. coli based on their characteristic virulence factors responsible for their associated clinical manifestations, ExPEC cannot be so easily distinguished. IPEC most likely have reservoirs outside of the human intestine but it is unclear if ExPEC represent nothing more than commensal E. coli that breach a sterile barrier to cause extraintestinal infections. This question has become more complicated by the advent of whole genome sequencing (WGS) that has raised a new question about the taxonomic characterization of E. coli based on traditional clinical microbiologic and phylogenetic methods. This review discusses how molecular epidemiologic approaches have been used to address these questions, and how answers to these questions may contribute to our better understanding of the epidemiology of infections caused by E. coli.
*This article is part of a curated collection.
Volumes & Issues
In the Spring of 2021, Microbiology Spectrum will relaunch as a new open access journal that will publish research from all domains of basic, applied and clinical microbial sciences. Rather than making subjective evaluations of potential impact, Microbiology Spectrum will publish research studies that are of high technical quality and are useful to the community. All decisions will be made by an international and diverse editorial board that fully represents the microbiology research community. The journal will provide authors with fair, rapid and rigorous peer review. In addition to studies that advance our collective understanding of microbial life, the journal will also consider:
- -Replication studies that are useful to the field
- -Findings that are of primary interest to smaller sub-fields within microbiology
- -Technically robust datasets that contradict published findings
- -Negative results of interest to microbiologists
- -Descriptive datasets that would serve as a community resource
- -Methodological advances and detailed experimental protocols that are of interest to microbiologists
- -Re-analyses of large datasets that provide additional insights
- -Experimental validation screening hits from previous reports
Topics Covered: Applied and Environmental Science, Clinical Science and Epidemiology, Ecological and Evolutionary Science, Host-Microbe Biology, Molecular Biology and Physiology, Synthetic Biology, Therapeutics and Prevention
To sign up to hear more about Microbiology Spectrum CLICK HERE