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Antimicrobial Resistance in spp., spp., and

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  • Authors: Andrea T. Feßler1, Stefan Schwarz2
  • Editors: Frank Møller Aarestrup3, Stefan Schwarz4, Jianzhong Shen5, Lina Cavaco6
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Institute of Microbiology and Epizootics, Centre of Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany; 2: Institute of Microbiology and Epizootics, Centre of Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany; 3: Technical University of Denmark, Lyngby, Denmark; 4: Friedrich-Loeffler-Institut, Neustadt, Germany; 5: China Agricultural University, Beijing, China; 6: Technical University of Denmark, Lyngby, Denmark
    • Source: microbiolspec December 2017 vol. 5 no. 6 doi:10.1128/microbiolspec.ARBA-0021-2017
  • Received 20 May 2017 Accepted 28 September 2017 Published 07 December 2017
  • Andrea T. Feßler, [email protected]
image of Antimicrobial Resistance in <span class="jp-italic">Corynebacterium</span> spp., <span class="jp-italic">Arcanobacterium</span> spp., and <span class="jp-italic">Trueperella pyogenes</span>
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  • Abstract:

    There is currently only limited information on the antimicrobial susceptibility and resistance of spp., spp., and from animals. The comparability of the data is hampered by the use of different antimicrobial susceptibility testing methods and interpretive criteria. To date, standard broth microdilution methods and clinical breakpoints that are approved by the Clinical and Laboratory Standards Institute and are applicable to spp., spp., and are available. The lack of species-specific clinical breakpoints for the different animal species reduces the explanatory power of the data. Among the isolates of the three genera, elevated MICs for different classes of antimicrobial agents (e.g., β-lactams, macrolides, lincosamides, tetracyclines, aminoglycosides, phenicols, sulfonamides/diaminopyrimidines, and fluoroquinolones) have been described. The most comprehensive data set is available for , which also includes information about genes and mutations involved in antimicrobial resistance. In isolates, the macrolide-lincosamide-streptogramin B resistance genes (B) and (X) were identified. Tetracycline resistance in was based on the resistance genes (W), (Z), and (33), whereas the aminoglycoside resistance genes , , , , , and have been described in . So far, only single genes conferring either phenicol resistance (), trimethoprim resistance (), or β-lactam resistance () are known to occur in isolates. Various 23S rRNA mutations, including A2058T, A2058G, and G2137C, were identified in macrolide/lincosamide-resistant .

  • Citation: Feßler A, Schwarz S. 2017. Antimicrobial Resistance in spp., spp., and . Microbiol Spectrum 5(6):ARBA-0021-2017. doi:10.1128/microbiolspec.ARBA-0021-2017.

References

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2017-12-07
2021-01-24

Abstract:

There is currently only limited information on the antimicrobial susceptibility and resistance of spp., spp., and from animals. The comparability of the data is hampered by the use of different antimicrobial susceptibility testing methods and interpretive criteria. To date, standard broth microdilution methods and clinical breakpoints that are approved by the Clinical and Laboratory Standards Institute and are applicable to spp., spp., and are available. The lack of species-specific clinical breakpoints for the different animal species reduces the explanatory power of the data. Among the isolates of the three genera, elevated MICs for different classes of antimicrobial agents (e.g., β-lactams, macrolides, lincosamides, tetracyclines, aminoglycosides, phenicols, sulfonamides/diaminopyrimidines, and fluoroquinolones) have been described. The most comprehensive data set is available for , which also includes information about genes and mutations involved in antimicrobial resistance. In isolates, the macrolide-lincosamide-streptogramin B resistance genes (B) and (X) were identified. Tetracycline resistance in was based on the resistance genes (W), (Z), and (33), whereas the aminoglycoside resistance genes , , , , , and have been described in . So far, only single genes conferring either phenicol resistance (), trimethoprim resistance (), or β-lactam resistance () are known to occur in isolates. Various 23S rRNA mutations, including A2058T, A2058G, and G2137C, were identified in macrolide/lincosamide-resistant .

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Antimicrobial Resistance in spp., spp., and
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Citation: Feßler A, Schwarz S. 2017. Antimicrobial resistance in spp., spp., and . microbiolspec 5(6): doi:10.1128/microbiolspec.ARBA-0021-2017
/content/microbiolspec/10.1128/microbiolspec.ARBA-0021-2017.T1
TABLE 1
Examples of different AST methods and test conditions
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TABLE 1

Examples of different AST methods and test conditions

Source: microbiolspec December 2017 vol. 5 no. 6 doi:10.1128/microbiolspec.ARBA-0021-2017
/content/microbiolspec/10.1128/microbiolspec.ARBA-0021-2017.T2
TABLE 2
spp. AST data determined by broth microdilution according to CLSI/NCCLS standards
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TABLE 2

spp. AST data determined by broth microdilution according to CLSI/NCCLS standards

Source: microbiolspec December 2017 vol. 5 no. 6 doi:10.1128/microbiolspec.ARBA-0021-2017
/content/microbiolspec/10.1128/microbiolspec.ARBA-0021-2017.T3
TABLE 3
AST data determined by broth microdilution according to CLSI/NCCLS standards
Generic image for table

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TABLE 3

AST data determined by broth microdilution according to CLSI/NCCLS standards

Source: microbiolspec December 2017 vol. 5 no. 6 doi:10.1128/microbiolspec.ARBA-0021-2017

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