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The Endosymbionts

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.
  • Author: Frédéric Landmann1
  • Editors: Pascale Cossart2, Craig R. Roy3, Philippe Sansonetti4
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: CRBM, University of Montpellier, CNRS, Montpellier, France; 2: Institut Pasteur, Paris, France; 3: Yale University School of Medicine, New Haven, Connecticut; 4: Institut Pasteur, Paris, France
  • Source: microbiolspec April 2019 vol. 7 no. 2 doi:10.1128/microbiolspec.BAI-0018-2019
  • Received 04 June 2018 Accepted 10 January 2019 Published 12 April 2019
  • Frédéric Landmann, [email protected]
image of The <span class="jp-italic">Wolbachia</span> Endosymbionts
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  • Abstract:

    The endosymbionts encompass a large group of intracellular bacteria of biomedical and veterinary relevance, closely related to , , and . This genus of Gram-negative members of the does not infect vertebrates but is instead restricted to ecdysozoan species, including terrestrial arthropods and a family of parasitic filarial nematodes, the Onchocercidae. The profoundly impact not only the ecology and evolution but also the reproductive biology of their hosts, through a wide range of symbiotic interactions. Because they are essential to the survival and reproduction of their filarial nematode hosts, they represent an attractive target to fight filariasis. Their abilities to spread through insect populations and to affect vector competence through pathogen protection have made a staple for controlling vector-borne diseases. Estimated to be present in up to 66% of insect species, the are probably the most abundant endosymbionts on earth. Their success resides in their unique capacity to infect and manipulate the host germ line to favor their vertical transmission through the maternal lineage. Because the resist genetic manipulation and growth in axenic culture, our understanding of their biology is still in its infancy. Despite these limitations, the “-omics” revolution combined with the use of well-established and emerging experimental host models is accelerating our comprehension of the host phenotypes caused by , and the identification of effectors is ongoing.

  • Citation: Landmann F. 2019. The Endosymbionts. Microbiol Spectrum 7(2):BAI-0018-2019. doi:10.1128/microbiolspec.BAI-0018-2019.

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/content/journal/microbiolspec/10.1128/microbiolspec.BAI-0018-2019
2019-04-12
2019-08-22

Abstract:

The endosymbionts encompass a large group of intracellular bacteria of biomedical and veterinary relevance, closely related to , , and . This genus of Gram-negative members of the does not infect vertebrates but is instead restricted to ecdysozoan species, including terrestrial arthropods and a family of parasitic filarial nematodes, the Onchocercidae. The profoundly impact not only the ecology and evolution but also the reproductive biology of their hosts, through a wide range of symbiotic interactions. Because they are essential to the survival and reproduction of their filarial nematode hosts, they represent an attractive target to fight filariasis. Their abilities to spread through insect populations and to affect vector competence through pathogen protection have made a staple for controlling vector-borne diseases. Estimated to be present in up to 66% of insect species, the are probably the most abundant endosymbionts on earth. Their success resides in their unique capacity to infect and manipulate the host germ line to favor their vertical transmission through the maternal lineage. Because the resist genetic manipulation and growth in axenic culture, our understanding of their biology is still in its infancy. Despite these limitations, the “-omics” revolution combined with the use of well-established and emerging experimental host models is accelerating our comprehension of the host phenotypes caused by , and the identification of effectors is ongoing.

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Figures

Image of FIGURE 1
FIGURE 1

Overview of diversity. () Unrooted phylogenic tree of the main supergroups. The triangle size represents the described diversity within each supergroup. () Comparison of genomic features of endosymbionts with other pathogens. Bm and Mel, endosymbionts from and ; , ; , . Adapted from references 15 and 133 .

Source: microbiolspec April 2019 vol. 7 no. 2 doi:10.1128/microbiolspec.BAI-0018-2019
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Image of FIGURE 2
FIGURE 2

The four reproductive outcomes caused by , with an example of arthropod species described in the text. () Parthenogenesis, MK, and feminization cause a sex ratio distortion. () CI (left) and the rescue cross (right). Uninfected females cannot successfully mate with infected males (CI), while infected females have the selective advantage to mate with noninfected males or with males infected with a compatible strain.

Source: microbiolspec April 2019 vol. 7 no. 2 doi:10.1128/microbiolspec.BAI-0018-2019
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FIGURE 3

Germ line tropism and transmission in insect and nematode species. () Schematic representation of oogenesis. The germ line is in white, and the surrounding somatic follicle cells are in gray. For the sake of clarity, are not represented within the germarium, where they colonize the GSCs and associated niche (GSCN) (dark and light purple, respectively), as well as the somatic stem cell niche (SSCN; pink). In developing cysts, polar cells (PCs) are yellow, the microtubule (green) polarity is indicated by plus and minus signs, and the organisms are red foci. Nuclei of developing cysts are depicted in blue. () Asymmetric segregation of during early embryogenesis in . The confocal image of a fertilized egg shows the (red foci) in the posterior compartment around the centrosome (green) during the first anaphase. The route followed by to reach the hypodermis in the early lineage is highlighted in black. The P lineage represents the germ line precursor lineage, left by after the P2 division to concentrate in the hypodermal precursor C blastomere. () Schematic cross section of a female, with an emphasis on the tissues infected by . The confocal image shows the tropism of some organisms from the hypodermis to the somatic gonad in a juvenile female. Asterisks indicate the entry and proliferation of in the somatic ovarian distal sheath cells.

Source: microbiolspec April 2019 vol. 7 no. 2 doi:10.1128/microbiolspec.BAI-0018-2019
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