Epstein-Barr Virus
- Authors: Andrew Nowalk1, Michael Green2
- Editors: Randall T. Hayden3, Donna M. Wolk4, Karen C. Carroll5, Yi-Wei Tang6
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VIEW AFFILIATIONS HIDE AFFILIATIONSAffiliations: 1: University of Pittsburgh School of Medicine, Division of Infectious Diseases, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224; 2: University of Pittsburgh School of Medicine, Division of Infectious Diseases, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224; 3: St. Jude’s Children’s Research Hospital, Memphis, TN; 4: Geisinger Clinic, Danville, PA; 5: Johns Hopkins University Hospital, Baltimore, MD; 6: Memorial Sloan-Kettering Institute, New York, NY
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Received 08 May 2015 Accepted 08 February 2016 Published 24 June 2016
- Correspondence: Michael Green, [email protected]
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Abstract:
This review covers relevant clinical and laboratory information relating to Epstein-Barr virus (EBV) infections in immunocompromised hosts. It describes the epidemiology and clinical manifestations with a primary focus on disease in solid organ and stem cell transplant recipients. The review pays particular attention to diagnostic approaches, including serologic testing and imaging, with an expanded discussion on the role of measuring the EBV load in peripheral blood, identifying both strengths and limitations of this assay. Additional attention is paid to potential additional strategies of immunologic monitoring that may enhance the performance of EBV load monitoring.
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Citation: Nowalk A, Green M. 2016. Epstein-Barr Virus. Microbiol Spectrum 4(3):DMIH2-0011-2015. doi:10.1128/microbiolspec.DMIH2-0011-2015.




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Abstract:
This review covers relevant clinical and laboratory information relating to Epstein-Barr virus (EBV) infections in immunocompromised hosts. It describes the epidemiology and clinical manifestations with a primary focus on disease in solid organ and stem cell transplant recipients. The review pays particular attention to diagnostic approaches, including serologic testing and imaging, with an expanded discussion on the role of measuring the EBV load in peripheral blood, identifying both strengths and limitations of this assay. Additional attention is paid to potential additional strategies of immunologic monitoring that may enhance the performance of EBV load monitoring.

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TABLE 1
Cumulative 1- and 5-year incidence of PTLD in pediatric and adult SOT recipients by transplanted organ as reported in the 2010 Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) Annual Report ( 9 ) a
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