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Epstein-Barr Virus

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  • Authors: Andrew Nowalk1, Michael Green2
  • Editors: Randall T. Hayden3, Donna M. Wolk4, Karen C. Carroll5, Yi-Wei Tang6
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: University of Pittsburgh School of Medicine, Division of Infectious Diseases, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224; 2: University of Pittsburgh School of Medicine, Division of Infectious Diseases, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224; 3: St. Jude’s Children’s Research Hospital, Memphis, TN; 4: Geisinger Clinic, Danville, PA; 5: Johns Hopkins University Hospital, Baltimore, MD; 6: Memorial Sloan-Kettering Institute, New York, NY
    • Source: microbiolspec June 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.DMIH2-0011-2015
  • Received 08 May 2015 Accepted 08 February 2016 Published 24 June 2016
  • Michael Green, [email protected]
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  • Abstract:

    This review covers relevant clinical and laboratory information relating to Epstein-Barr virus (EBV) infections in immunocompromised hosts. It describes the epidemiology and clinical manifestations with a primary focus on disease in solid organ and stem cell transplant recipients. The review pays particular attention to diagnostic approaches, including serologic testing and imaging, with an expanded discussion on the role of measuring the EBV load in peripheral blood, identifying both strengths and limitations of this assay. Additional attention is paid to potential additional strategies of immunologic monitoring that may enhance the performance of EBV load monitoring.

  • Citation: Nowalk A, Green M. 2016. Epstein-Barr Virus. Microbiol Spectrum 4(3):DMIH2-0011-2015. doi:10.1128/microbiolspec.DMIH2-0011-2015.

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References

1. Cohen JI. 2000. Epstein-Barr virus infection. N Engl J Med 343:481–492. [PubMed][CrossRef]
2. Green M, Michaels MG. 2013. Epstein-Barr virus infection and posttransplant lymphoproliferative disorder. Am J Transplant 13(Suppl 3) :41–54, quiz 54. [PubMed][CrossRef]
3. Smets F, Bodeus M, Goubau P, Reding R, Otte JB, Buts JP, Sokal EM. 2000. Characteristics of Epstein-Barr virus primary infection in pediatric liver transplant recipients. J Hepatol 32:100–104. [PubMed][CrossRef]
4. Hsu JL, Glaser SL. 2000. Epstein-Barr virus-associated malignancies: epidemiologic patterns and etiologic implications. Crit Rev Oncol Hematol 34:27–53. [PubMed][CrossRef]
5. Allen UD, Preiksaitis JK, AST Infectious Diseases Community of Practice. 2013. Epstein-Barr virus and posttransplant lymphoproliferative disorder in solid organ transplantation. Am J Transplant 13(Suppl 4) :107–120. [PubMed][CrossRef]
6. Rasche L, Kapp M, Einsele H, Mielke S. 2014. EBV-induced post transplant lymphoproliferative disorders: a persisting challenge in allogeneic hematopoetic SCT. Bone Marrow Transplant 49:163–167. [PubMed][CrossRef]
7. Green M, Webber S. 2003. Posttransplantation lymphoproliferative disorders. Pediatr Clin North Am 50:1471–1491. [PubMed][CrossRef]
8. Ramos E, Hernández F, Andres A, Martínez-Ojinaga E, Molina M, Sarría J, Lopez-Santamaria M, Prieto G. 2013. Post-transplant lymphoproliferative disorders and other malignancies after pediatric intestinal transplantation: incidence, clinical features and outcome. Pediatr Transplant 17:472–478. [PubMed][CrossRef]
9. Organ Procurement and Transplantation Network and Scientific Registry of Transplant Recipients (SRTR). 2012. OPTN/SRTR 2010 Annual Data Report. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation. Am J Transplant 12(Supplement 1) :1–156.
10. Lau AH, Soltys K, Sindhi RK, Bond G, Mazariegos GV, Green M. 2010. Chronic high Epstein-Barr viral load carriage in pediatric small bowel transplant recipients. Pediatr Transplant 14:549–553. [PubMed][CrossRef]
11. Green M, Soltys K, Rowe DT, Webber SA, Mazareigos G. 2009. Chronic high Epstein-Barr viral load carriage in pediatric liver transplant recipients. Pediatr Transplant 13:319–323. [PubMed][CrossRef]
12. García-Cadenas I, Castillo N, Martino R, Barba P, Esquirol A, Novelli S, Orti G, Garrido A, Saavedra S, Moreno C, Granell M, Briones J, Brunet S, Navarro F, Ruiz I, Rabella N, Valcárcel D, Sierra J. 2015. Impact of Epstein Barr virus-related complications after high-risk allo-SCT in the era of pre-emptive rituximab. Bone Marrow Transplant 50:579–584. [PubMed][CrossRef]
13. Pinana JL, Sanz J, Esquirol A, Martino R, Picardi A, Barbas P, Parody R, Gayoso J, Montesinos P, Guidi S, Terol MJ, Moscard F, Solano C, Arcese W, Sanz MA, Sierra J, Sanz G. On behalf of GETH GITMO Groups. 2015. Umbilical cord blood transplantation in adults with advanced hodgkin’s disease: high incidence of post-transplant lymphoproliferative disease. Eur J Haematol 96:128–135. [PubMed][CrossRef]
14. Chandrakasan S, Filipovich AH. 2013. Hemophagocytic lymphohistiocytosis: advances in pathophysiology, diagnosis, and treatment. J Pediatr 163:1253–1259. [PubMed][CrossRef]
15. Pinzone MR, Berretta M, Cacopardo B, Nunnari G. 2015. Epstein-Barr virus- and Kaposi sarcoma-associated herpesvirus-related malignancies in the setting of human immunodeficiency virus infection. Semin Oncol 42:258–271. [PubMed][CrossRef]
16. Allen U, Preiksaitis J, AST Infectious Diseases Community of Practice. 2009. Epstein-Barr virus and posttransplant lymphoproliferative disorder in solid organ transplant recipients. Am J Transplant 9(Suppl 4) :S87–S96. [PubMed][CrossRef]
17. Loechelt BJ, et al. 2014. Screening and monitoring for infectious complications when immunosuppressive agents are studied in the treatment of autoimmune disorders. J Pediatric Infect Dis Soc. [PubMed]
18. Worth A, Conyers R, Cohen J, Jagani M, Chiesa R, Rao K, Goulden N, Veys P, Amrolia PJ. 2011. Pre-emptive rituximab based on viraemia and T cell reconstitution: a highly effective strategy for the prevention of Epstein-Barr virus-associated lymphoproliferative disease following stem cell transplantation. Br J Haematol 155:377–385. [PubMed][CrossRef]
19. Juvonen E, Aalto S, Tarkkanen J, Volin L, Hedman K, Ruutu T. 2007. Retrospective evaluation of serum Epstein Barr virus DNA levels in 406 allogeneic stem cell transplant patients. Haematologica 92:819–825. [PubMed][CrossRef]
20. Preiksaitis JK, Pang XL, Fox JD, Fenton JM, Caliendo AM, Miller GG, American Society of Transplantation Infectious Diseases Community of Practice. 2009. Interlaboratory comparison of Epstein-Barr virus viral load assays. Am J Transplant 9:269–279. [PubMed][CrossRef]
21. Fryer JF HA, Wilkinson DE, Minor PD and the Collaborative Study Group. 2011. Collaborative study to evaluate the proposed 1st WHO International Standard for Epstein-Barr Virus (EBV) for nucleic acid amplification (NAT)-based assays. World Health Organization, Geneva, Switzerland. http://apps.who.int/iris/bitstream/10665/70781/1/WHO_BS_2011.2172_org.pdf.
22. Michelson P, Watkins B, Webber SA, Wadowsky R, Michaels MG. 2008. Screening for PTLD in lung and heart-lung transplant recipients by measuring EBV DNA load in bronchoalveolar lavage fluid using real time PCR. Pediatr Transplant 12:464–468. [PubMed][CrossRef]
23. Bingler MA, Feingold B, Miller SA, Quivers E, Michaels MG, Green M, Wadowsky RM, Rowe DT, Webber SA. 2008. Chronic high Epstein-Barr viral load state and risk for late-onset posttransplant lymphoproliferative disease/lymphoma in children. Am J Transplant 8:442–445. [PubMed][CrossRef]
24. Preiksaitis J. 2010. Epstein-Barr viral load testing: role in the prevention, diagnosis and management of posttransplant lymphoproliferative disorders, p 45–68. In Dharnidharka VR, Green M, Webber S (ed), Post-Transplant Lymphoproliferative Disorders. Springer, New York. [CrossRef]
25. Rowe DT, Qu L, Reyes J, Jabbour N, Yunis E, Putnam P, Todo S, Green M. 1997. Use of quantitative competitive PCR to measure Epstein-Barr virus genome load in the peripheral blood of pediatric transplant patients with lymphoproliferative disorders. J Clin Microbiol 35:1612–1615. [PubMed]
26. Tsai DE, Douglas L, Andreadis C, Vogl DT, Arnoldi S, Kotloff R, Svoboda J, Bloom RD, Olthoff KM, Brozena SC, Schuster SJ, Stadtmauer EA, Robertson ES, Wasik MA, Ahya VN. 2008. EBV PCR in the diagnosis and monitoring of posttransplant lymphoproliferative disorder: results of a two-arm prospective trial. Am J Transplant 8:1016–1024. [PubMed][CrossRef]
27. Wadowsky RM, Laus S, Green M, Webber SA, Rowe D. 2003. Measurement of Epstein-Barr virus DNA loads in whole blood and plasma by TaqMan PCR and in peripheral blood lymphocytes by competitive PCR. J Clin Microbiol 41:5245–5249. [PubMed][CrossRef]
28. Chowdhury FU, Sheerin F, Bradley KM, Gleeson FV. 2009. PET/CT staging and response evaluation of post-transplantation lymphoproliferative disease (PTLD). Clin Nucl Med 34:386–387. [PubMed][CrossRef]
29. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD. 2000. The World Health Organization classification of hematological malignancies report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997. Mod Pathol 13:193–207. [PubMed][CrossRef]
30. Young L, Alfieri C, Hennessy K, Evans H, O'Hara C, Anderson KC, Ritz J, Shapiro RS, Rickington A, Kieff E, Cohen JL. 1989. Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N Engl J Med 321:1080–1085. [PubMed][CrossRef]
31. Macedo C, Zeevi A, Bentlejewski C, Popescu I, Green M, Rowe D, Smith L, Webber S, Metes D. 2009. The impact of EBV load on T-cell immunity in pediatric thoracic transplant recipients. Transplantation 88:123–128. [PubMed][CrossRef]
32. Smets F, Latinne D, Bazin H, Reding R, Otte JB, Buts JP, Sokal EM. 2002. Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease. Transplantation 73:1603–1610. [PubMed][CrossRef]
33. Lee TC, Goss JA, Rooney CM, Heslop HE, Barshes NR, Caldwell YM, Gee AP, Scott JD, Savoldo B. 2006. Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection. Clin Transplant 20:689–694. [PubMed][CrossRef]
34. Schubert S, Renner C, Hammer M, Abdul-Khaliq H, Lehmkuhl HB, Berger F, Hetzer R, Reinke P. 2008. Relationship of immunosuppression to Epstein-Barr viral load and lymphoproliferative disease in pediatric heart transplant patients. J Heart Lung Transplant 27:100–105. [PubMed][CrossRef]
35. Green M, Bueno J, Rowe D, Mazariegos G, Qu L, Abu-Almagd K, Reyes J. 2000. Predictive negative value of persistent low Epstein-Barr virus viral load after intestinal transplantation in children. Transplantation 70:593–596. [PubMed][CrossRef]
36. Gross TG. 2009. Treatment for Epstein-Barr virus-associated PTLD. Herpes 15:64–67. [PubMed]
37. San-Juan R, Manuel O, Hirsch HH, Fernández-Ruiz M, López-Medrano F, Comoli P, Caillard S, Grossi P, Aguado JM, ESGICH PTLD Survey Study Group, European Study Group of Infections in Compromised Hosts (ESGICH) from the European Society of Microbiology and Infectious Diseases (ESCMID). 2015. Current preventive strategies and management of Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplantation in Europe. Results of the ESGICH Questionnaire-based Cross-sectional Survey. Clin Microbiol Infect 21:604.e1–604.e9. [PubMed][CrossRef]
38. Gross T, Orjuela MA, Perkins SL, Park JR, Lynch JC, Cairo MS, Smith LM, Hayashi RJ. 2012. Low-dose chemotherapy and rituximab for post-transplant disease (PTLD): A Children’s Oncology Group report. Am J Transplant 12:3069–3075. [PubMed][CrossRef]
39. Savoldo B, Goss JA, Hammer MM, Zhang L, Lopez T, Gee AP, Lin YF, Quiros-Tejeira RE, Reinke P, Schubert S, Gottschalk S, Finegold MJ, Brenner MK, Rooney CM, Heslop HE. 2006. Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs). Blood 108:2942–2949. [PubMed][CrossRef]
40. Ricciardelli I, Brewin J, Lugthart G, Albon SJ, Pule M, Amrolia PJ. 2013. Rapid generation of EBV-specific cytotoxic T lymphocytes resistant to calcineurin inhibitors for adoptive immunotherapy. Am J Transplant 13:3244–3252. [PubMed][CrossRef]
41. Ricciardelli I, Blundell MP, Brewin J, Thrasher A, Pule M, Amrolia PJ. 2014. Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells. Blood 124:2514–2522. [PubMed][CrossRef]
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2016-06-24
2019-08-25

Abstract:

This review covers relevant clinical and laboratory information relating to Epstein-Barr virus (EBV) infections in immunocompromised hosts. It describes the epidemiology and clinical manifestations with a primary focus on disease in solid organ and stem cell transplant recipients. The review pays particular attention to diagnostic approaches, including serologic testing and imaging, with an expanded discussion on the role of measuring the EBV load in peripheral blood, identifying both strengths and limitations of this assay. Additional attention is paid to potential additional strategies of immunologic monitoring that may enhance the performance of EBV load monitoring.

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Epstein-Barr Virus
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Citation: Nowalk A, Green M. 2016. Epstein-barr virus. microbiolspec 4(3): doi:10.1128/microbiolspec.DMIH2-0011-2015
/content/microbiolspec/10.1128/microbiolspec.DMIH2-0011-2015.T1
TABLE 1

Cumulative 1- and 5-year incidence of PTLD in pediatric and adult SOT recipients by transplanted organ as reported in the 2010 Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) Annual Report ( 9 )

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TABLE 1

Cumulative 1- and 5-year incidence of PTLD in pediatric and adult SOT recipients by transplanted organ as reported in the 2010 Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) Annual Report ( 9 )

Source: microbiolspec June 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.DMIH2-0011-2015

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