Cronobacter spp.
- Authors: Brian P. Blackwood1, Catherine J. Hunter2
- Editors: W. Michael Scheld3, James M. Hughes4, Richard J. Whitley5
-
VIEW AFFILIATIONS HIDE AFFILIATIONSAffiliations: 1: Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611; 2: Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611; 3: Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA; 4: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA; 5: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
-
Received 24 August 2015 Accepted 28 September 2015 Published 22 April 2016
- Correspondence: Brian P. Blackwood, [email protected]

-
Abstract:
The Cronobacter group of pathogens, associated with severe and potentially life-threatening diseases, until recently were classified as a single species, Enterobacter sakazakii. The group was reclassified in 2007 into the genus Cronobacter as a member of the Enterobacteriaceae. This chapter outlines the history behind the epidemiology, analyzes how our understanding of these bacteria has evolved, and highlights the clinical significance the Cronobacter spp. have for neonatal and elderly patient populations and treatment of the associated infections.
-
Citation: Blackwood B, Hunter C. 2016. Cronobacter spp.. Microbiol Spectrum 4(2):EI10-0002-2015. doi:10.1128/microbiolspec.EI10-0002-2015.




Cronobacter spp., Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/microbiolspec/4/2/EI10-0002-2015-1.gif /docserver/preview/fulltext/microbiolspec/4/2/EI10-0002-2015-2.gif

References

Article metrics loading...
Abstract:
The Cronobacter group of pathogens, associated with severe and potentially life-threatening diseases, until recently were classified as a single species, Enterobacter sakazakii. The group was reclassified in 2007 into the genus Cronobacter as a member of the Enterobacteriaceae. This chapter outlines the history behind the epidemiology, analyzes how our understanding of these bacteria has evolved, and highlights the clinical significance the Cronobacter spp. have for neonatal and elderly patient populations and treatment of the associated infections.

Full text loading...
Figures
Image is taken at magnification of ×100 with z-stack under fluorescein isothiocyanate, 4′,6-diamidino-2-phenylindole (DAPI), and differential interference contrast channels. Cronobacter sakazakii has been cloned with green fluorescent protein expression and is shown in green; the nucleus is stained with DAPI and shown in blue. C. sakazakii can be seen to permeabilize the cell (Caco-2). Scale bar is 15 μm.

Click to view
FIGURE 1
Image is taken at magnification of ×100 with z-stack under fluorescein isothiocyanate, 4′,6-diamidino-2-phenylindole (DAPI), and differential interference contrast channels. Cronobacter sakazakii has been cloned with green fluorescent protein expression and is shown in green; the nucleus is stained with DAPI and shown in blue. C. sakazakii can be seen to permeabilize the cell (Caco-2). Scale bar is 15 μm.
Rat pups fed formula contaminated with C. sakazakii have findings resembling neonatal NEC. The rat pup bowel is dilated, and pneumatosis can be clearly seen in the bowel wall.

Click to view
FIGURE 2
Rat pups fed formula contaminated with C. sakazakii have findings resembling neonatal NEC. The rat pup bowel is dilated, and pneumatosis can be clearly seen in the bowel wall.
Supplemental Material
No supplementary material available for this content.