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  • Authors: Brian P. Blackwood1, Catherine J. Hunter2
  • Editors: W. Michael Scheld3, James M. Hughes4, Richard J. Whitley5
    Affiliations: 1: Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611; 2: Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611; 3: Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA; 4: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA; 5: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
  • Source: microbiolspec April 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0002-2015
  • Received 24 August 2015 Accepted 28 September 2015 Published 22 April 2016
  • Brian P. Blackwood, [email protected]
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  • Abstract:

    The group of pathogens, associated with severe and potentially life-threatening diseases, until recently were classified as a single species, . The group was reclassified in 2007 into the genus as a member of the . This chapter outlines the history behind the epidemiology, analyzes how our understanding of these bacteria has evolved, and highlights the clinical significance the spp. have for neonatal and elderly patient populations and treatment of the associated infections.

  • Citation: Blackwood B, Hunter C. 2016. spp.. Microbiol Spectrum 4(2):EI10-0002-2015. doi:10.1128/microbiolspec.EI10-0002-2015.


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The group of pathogens, associated with severe and potentially life-threatening diseases, until recently were classified as a single species, . The group was reclassified in 2007 into the genus as a member of the . This chapter outlines the history behind the epidemiology, analyzes how our understanding of these bacteria has evolved, and highlights the clinical significance the spp. have for neonatal and elderly patient populations and treatment of the associated infections.

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Image of FIGURE 1

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Image is taken at magnification of ×100 with z-stack under fluorescein isothiocyanate, 4′,6-diamidino-2-phenylindole (DAPI), and differential interference contrast channels. has been cloned with green fluorescent protein expression and is shown in green; the nucleus is stained with DAPI and shown in blue. can be seen to permeabilize the cell (Caco-2). Scale bar is 15 μm.

Source: microbiolspec April 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0002-2015
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Image of FIGURE 2

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Rat pups fed formula contaminated with have findings resembling neonatal NEC. The rat pup bowel is dilated, and pneumatosis can be clearly seen in the bowel wall.

Source: microbiolspec April 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0002-2015
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