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Chikungunya Virus: Current Perspectives on a Reemerging Virus

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  • Authors: Clayton R. Morrison1, Kenneth S. Plante2, Mark T. Heise3
  • Editors: W. Michael Scheld4, James M. Hughes5, Richard J. Whitley6
    Affiliations: 1: Department of Genetics, The University of North Carolina, Chapel Hill, NC 27599; 2: Department of Genetics, The University of North Carolina, Chapel Hill, NC 27599; 3: Department of Genetics, The University of North Carolina, Chapel Hill, NC 27599; 4: Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA; 5: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA; 6: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
  • Source: microbiolspec May 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.EI10-0017-2016
  • Received 09 February 2016 Accepted 17 February 2016 Published 13 May 2016
  • Mark T. Heise, [email protected]
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  • Abstract:

    Chikungunya virus (CHIKV) is a mosquito-borne alphavirus in the family that causes outbreaks of debilitating acute and chronic arthralgia in humans. Although historically associated with localized outbreaks in Africa and Asia, recent epidemics in the Indian Ocean region and the Americas have led to the recognition that CHIKV is capable of moving into previously unaffected areas and causing significant levels of human suffering. The severity of CHIKV rheumatic disease, which can severely impact life quality of infected individuals for weeks, months, or even years, combined with the explosive nature of CHIKV outbreaks and its demonstrated ability to quickly spread into new regions, has led to renewed interest in developing strategies for the prevention or treatment of CHIKV-induced disease. Therefore, this chapter briefly discusses the biology of CHIKV and the factors contributing to CHIKV dissemination, while also discussing the pathogenesis of CHIKV-induced disease and summarizing the status of efforts to develop safe and effective therapies and vaccines against CHIKV and related viruses.

  • Citation: Morrison C, Plante K, Heise M. 2016. Chikungunya Virus: Current Perspectives on a Reemerging Virus. Microbiol Spectrum 4(3):EI10-0017-2016. doi:10.1128/microbiolspec.EI10-0017-2016.


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Chikungunya virus (CHIKV) is a mosquito-borne alphavirus in the family that causes outbreaks of debilitating acute and chronic arthralgia in humans. Although historically associated with localized outbreaks in Africa and Asia, recent epidemics in the Indian Ocean region and the Americas have led to the recognition that CHIKV is capable of moving into previously unaffected areas and causing significant levels of human suffering. The severity of CHIKV rheumatic disease, which can severely impact life quality of infected individuals for weeks, months, or even years, combined with the explosive nature of CHIKV outbreaks and its demonstrated ability to quickly spread into new regions, has led to renewed interest in developing strategies for the prevention or treatment of CHIKV-induced disease. Therefore, this chapter briefly discusses the biology of CHIKV and the factors contributing to CHIKV dissemination, while also discussing the pathogenesis of CHIKV-induced disease and summarizing the status of efforts to develop safe and effective therapies and vaccines against CHIKV and related viruses.

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CHIKV vaccine strategies

Source: microbiolspec May 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.EI10-0017-2016
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CHIKV antivirals

Source: microbiolspec May 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.EI10-0017-2016

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