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Infections Caused by Group C and G Streptococcus ( subsp. and Others): Epidemiological and Clinical Aspects

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  • Author: Gio J. Baracco1
  • Editors: Vincent A. Fischetti2, Richard P. Novick3, Joseph J. Ferretti4, Daniel A. Portnoy5, Julian I. Rood6
    Affiliations: 1: University of Miami Miller School of Medicine and Miami Veterans Affairs Healthcare System, Miami, FL 33125; 2: The Rockefeller University, New York, NY; 3: Skirball Institute for Molecular Medicine, NYU Medical Center, New York, NY; 4: Department of Microbiology & Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK; 5: Department of Molecular and Cellular Microbiology, University of California, Berkeley, Berkeley, CA; 6: Australian Bacterial Pathogen Program, Department of Microbiology, Monash University, Melbourne, Australia
  • Source: microbiolspec April 2019 vol. 7 no. 2 doi:10.1128/microbiolspec.GPP3-0016-2018
  • Received 24 April 2018 Accepted 25 April 2018 Published 12 April 2019
  • Gio J. Baracco, [email protected]
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  • Abstract:

    Streptococci carrying serogroup C and G antigens, and in particular, subsp. (SDSE), are emerging human pathogens that are increasingly isolated from patients with a myriad of infections that range from mundane to life-threatening. SDSE is microbiologically similar to . These streptococci frequently cause infections of the throat and skin and soft tissues. Moreover, they may invade the bloodstream and disseminate widely to many deep tissue sites, including the endocardium. Life-threatening invasive infections due to SDSE, including the streptococcal toxic shock syndrome, occur most frequently in patients with severe underlying medical diseases. Treatment with penicillin is adequate under most circumstances, but treatment failure occurs. SDSE may also be resistant to other antibiotic classes including tetracyclines, macrolides, and clindamycin. Most human infections caused by groups C and G streptococci are transmitted from person to person, but infections due to subsp. (and, rarely, to subsp. ) are zoonoses. Transmission of these latter species occurs by animal contact or by contamination of food products and has been associated with the development of poststreptococcal glomerulonephritis. Members of the group, usually classified with the viridans group of streptococci, are associated with a variety of pyogenic infections.

  • Citation: Baracco G. 2019. Infections Caused by Group C and G Streptococcus ( subsp. and Others): Epidemiological and Clinical Aspects. Microbiol Spectrum 7(2):GPP3-0016-2018. doi:10.1128/microbiolspec.GPP3-0016-2018.


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Streptococci carrying serogroup C and G antigens, and in particular, subsp. (SDSE), are emerging human pathogens that are increasingly isolated from patients with a myriad of infections that range from mundane to life-threatening. SDSE is microbiologically similar to . These streptococci frequently cause infections of the throat and skin and soft tissues. Moreover, they may invade the bloodstream and disseminate widely to many deep tissue sites, including the endocardium. Life-threatening invasive infections due to SDSE, including the streptococcal toxic shock syndrome, occur most frequently in patients with severe underlying medical diseases. Treatment with penicillin is adequate under most circumstances, but treatment failure occurs. SDSE may also be resistant to other antibiotic classes including tetracyclines, macrolides, and clindamycin. Most human infections caused by groups C and G streptococci are transmitted from person to person, but infections due to subsp. (and, rarely, to subsp. ) are zoonoses. Transmission of these latter species occurs by animal contact or by contamination of food products and has been associated with the development of poststreptococcal glomerulonephritis. Members of the group, usually classified with the viridans group of streptococci, are associated with a variety of pyogenic infections.

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