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Immunology of Infections

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  • Authors: Jonathan Kevin Sia1, Jyothi Rengarajan2
  • Editors: Vincent A. Fischetti3, Richard P. Novick4, Joseph J. Ferretti5, Daniel A. Portnoy6, Miriam Braunstein7, Julian I. Rood8
    Affiliations: 1: Emory Vaccine Center, Emory University School of Medicine, Emory University, Atlanta, GA 30329; 2: Department of Medicine, Division of Infectious Diseases and Emory Vaccine Center, Emory University School of Medicine, Emory University, Atlanta, GA 30329; 3: The Rockefeller University, New York, NY; 4: Skirball Institute for Molecular Medicine, NYU Medical Center, New York, NY; 5: Department of Microbiology & Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK; 6: Department of Molecular and Cellular Microbiology, University of California, Berkeley, Berkeley, CA; 7: Department of Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, NC; 8: Australian Bacterial Pathogen Program, Department of Microbiology, Monash University, Melbourne, Australia
  • Source: microbiolspec July 2019 vol. 7 no. 4 doi:10.1128/microbiolspec.GPP3-0022-2018
  • Received 30 April 2018 Accepted 10 May 2018 Published 12 July 2019
  • Jyothi Rengarajan, [email protected]
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  • Abstract:

    Tuberculosis (TB) is a serious global public health challenge that results in significant morbidity and mortality worldwide. TB is caused by infection with the bacilli (), which has evolved a wide variety of strategies in order to thrive within its host. Understanding the complex interactions between and host immunity can inform the rational design of better TB vaccines and therapeutics. This chapter covers innate and adaptive immunity against infection, including insights on bacterial immune evasion and subversion garnered from animal models of infection and human studies. In addition, this chapter discusses the immunology of the TB granuloma, TB diagnostics, and TB comorbidities. Finally, this chapter provides a broad overview of the current TB vaccine pipeline.

  • Citation: Sia J, Rengarajan J. 2019. Immunology of Infections. Microbiol Spectrum 7(4):GPP3-0022-2018. doi:10.1128/microbiolspec.GPP3-0022-2018.


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