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Fulminant Staphylococcal Infections

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  • Authors: Yves Gillet1, Thomas Henry3, Francois Vandenesch4
  • Editors: Vincent A. Fischetti6, Richard P. Novick7, Joseph J. Ferretti8, Daniel A. Portnoy9, Miriam Braunstein10, Julian I. Rood11
    Affiliations: 1: Department of Pediatric Emergency, Hospices Civils de Lyon, Hôpital Femme Mère Enfant, F-69677, Bron, France; 2: CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University of Lyon, F-69007, Lyon, France; 3: CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University of Lyon, F-69007, Lyon, France; 4: CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University of Lyon, F-69007, Lyon, France; 5: IAI, Institut des Agents Infectieux, National Reference Center for Staphylococci, Hospices Civils de Lyon, Hôpital de la Croix Rousse, F-69004 Lyon, France; 6: The Rockefeller University, New York, NY; 7: Skirball Institute for Molecular Medicine, NYU Medical Center, New York, NY; 8: Department of Microbiology & Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK; 9: Department of Molecular and Cellular Microbiology, University of California, Berkeley, Berkeley, CA; 10: Department of Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, NC; 11: Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia
  • Source: microbiolspec October 2018 vol. 6 no. 5 doi:10.1128/microbiolspec.GPP3-0036-2018
  • Received 17 July 2018 Accepted 06 August 2018 Published 11 October 2018
  • Francois Vandenesch, [email protected]
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  • Abstract:

    Fulminant staphylococcal infection indicates an explosive, intense, and severe infection occurring in a patient whose previous condition and antecedent would never have caused any anticipation of life-threatening development. This includes necrotizing pneumonia, necrotizing fasciitis, and to some extent toxic shock syndrome and infective endocarditis. In the three former diseases, toxin production plays a major role whereas in the latter (fulminant presentation of infective endocarditis), association with any particular toxinic profile has never been demonstrated. This article reviews the clinical, pathophysiological, and therapeutic aspects of these diseases.

  • Citation: Gillet Y, Henry T, Vandenesch F. 2018. Fulminant Staphylococcal Infections. Microbiol Spectrum 6(5):GPP3-0036-2018. doi:10.1128/microbiolspec.GPP3-0036-2018.


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Fulminant staphylococcal infection indicates an explosive, intense, and severe infection occurring in a patient whose previous condition and antecedent would never have caused any anticipation of life-threatening development. This includes necrotizing pneumonia, necrotizing fasciitis, and to some extent toxic shock syndrome and infective endocarditis. In the three former diseases, toxin production plays a major role whereas in the latter (fulminant presentation of infective endocarditis), association with any particular toxinic profile has never been demonstrated. This article reviews the clinical, pathophysiological, and therapeutic aspects of these diseases.

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Case definition of staphylococcal TSS

Source: microbiolspec October 2018 vol. 6 no. 5 doi:10.1128/microbiolspec.GPP3-0036-2018

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