1887
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.

Pathogenesis — Thoughts from the Front Line

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.
  • PDF
    176.99 Kb
  • HTML
    67.51 Kb
  • XML
    52.94 Kb
  • Author: James P. Nataro1
  • Editors: Tyrrell Conway2, Paul Cohen3
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: University of Virginia; 2: Oklahoma State University, Stillwater, OK; 3: University of Rhode Island, Kingston, RI
    • Source: microbiolspec June 2015 vol. 3 no. 3 doi:10.1128/microbiolspec.MBP-0012-2014
  • Received 05 December 2014 Accepted 07 January 2015 Published 11 June 2015
  • James Nataro, [email protected]
image of Pathogenesis — Thoughts from the Front Line
    Preview this microbiology spectrum article:
    Preview Magnify
    Zoom in
    Zoomout

    Pathogenesis — Thoughts from the Front Line, Page 1 of 2

    | /docserver/preview/fulltext/microbiolspec/3/3/MBP-0012-2014-1.gif /docserver/preview/fulltext/microbiolspec/3/3/MBP-0012-2014-2.gif

  • Abstract:

    The field of bacterial pathogenesis has advanced dramatically in the last decade. High throughput molecular technologies have empowered scientists as never before. However, there remain some limitations, misconceptions and ambiguities in the field that may bedevil even the experienced investigator. Here, I consider some of the unanswered questions that are not readily tractable to even the most powerful technology.

  • Citation: Nataro J. 2015. Pathogenesis — Thoughts from the Front Line. Microbiol Spectrum 3(3):MBP-0012-2014. doi:10.1128/microbiolspec.MBP-0012-2014.

References

1. Bulloch, W. 1938. The History of Bacteriology. Dover Publications, Inc., New York.
2. Falkow S. 2008. I never met a microbe I didn't like. Nat Med 14:1053–1057. [PubMed][CrossRef]
3. Smith M. 1980. Introduction, p 11–16. In Achtman M, Makela PH, Skehel JJ, Koch MA (eds), The molecular basis of microbial pathogenicity. Verlag Chemie, Weinheim.
4. Falkow S. 1988. Molecular Koch's postulates applied to microbial pathogenicity. Rev Infect Dis 10(Suppl 2) :S274–S276. [PubMed][CrossRef]
5. Casadevall A, Pirofski LA. 2009. Virulence factors and their mechanisms of action: the view from a damage-response framework. J Water Health 7(Suppl 1) :S2–S18. [PubMed][CrossRef]
6. Casadevall A, Pirofski LA. 2014. What is a host? Incorporating the Microbiota into the ‘Damage-Response Framework’. Infect Immun 83(1) :2–7. [PubMed][CrossRef]
7. Pirofski LA, Casadevall A. 2008. The damage-response framework of microbial pathogenesis and infectious diseases. Adv Exp Med Biol 635:135–146. [PubMed][CrossRef]
8. Casadevall A, Pirofski LA. 2003. The damage-response framework of microbial pathogenesis. Nat Rev Microbiol 1:17–24. [PubMed][CrossRef]
9. Lathe R, Sapronova A, Kotelevtsev Y. 2014. Atherosclerosis and Alzheimer—diseases with a common cause? Inflammation, oxysterols, vasculature. BMC Geriatr 14:36. [PubMed][CrossRef]
10. Janakiram NB, Rao CV. 2014. The role of inflammation in colon cancer. Adv Exp Med Biol 816:25–52. [PubMed][CrossRef]
11. Levin BR. 1996. The evolution and maintenance of virulence in microparasites. Emerg Infect Dis 2:93–102. [PubMed][CrossRef]
12. Weissmann G. 2005. Rats, lice, and Zinsser. Emerg Infect Dis 11:492–496. [PubMed][CrossRef]
13. Radolf JD, Caimano MJ, Stevenson B, Hu LT. 2012. Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes. Nat Rev Microbiol 10:87–99. [PubMed][CrossRef]
14. Chi CY, Lin CC, Liao IC, Yao YC, Shen FC, Liu CC, Lin CF. 2014. Panton-Valentine leukocidin facilitates the escape of Staphylococcus aureus from human keratinocyte endosomes and induces apoptosis. J Infect Dis 209:224–235. [PubMed][CrossRef]
15. Lindsay BR, Chakraborty S, Harro C, Li S, Nataro JP, Sommerfelt H, Sack DA, Colin SO. 2014. Quantitative PCR and culture evaluation for enterotoxigenic Escherichia coli (ETEC) associated diarrhea in volunteers. FEMS Microbiol Lett 352:25–31. [PubMed][CrossRef]
16. Phillips G, Lopman B, Tam CC, Iturriza-Gomara M, Brown D, Gray J. 2009. Diagnosing norovirus-associated infectious intestinal disease using viral load. BMC Infect Dis 9:63. [PubMed][CrossRef]
17. Taniuchi M, Sobuz SU, Begum S, Platts-Mills JA, Liu J, Yang Z, Wang XQ, Petri WA, Jr., Haque R, Houpt ER. 2013. Etiology of diarrhea in Bangladeshi infants in the first year of life analyzed using molecular methods. J Infect Dis 208:1794–1802. [PubMed][CrossRef]
18. Bonner CA, Byrne GI, Jensen RA. 2014. Chlamydia exploit the mammalian tryptophan-depletion defense strategy as a counter-defensive cue to trigger a survival state of persistence. Front Cell Infect Microbiol 4:17. [PubMed][CrossRef]
19. Xie G, Bonner CA, Jensen RA. 2002. Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture. Genome Biol 3(9) :research0051.1–research0051.17.
20. Rivera-Chavez F, Winter SE, Lopez CA, Xavier MN, Winter MG, Nuccio SP, Russell JM, Laughlin RC, Lawhon SD, Sterzenbach T, Bevins CL, Tsolis RM, Harshey R, Adams LG, Baumler AJ. 2013. Salmonella uses energy taxis to benefit from intestinal inflammation. PLoS Pathog 9:e1003267. [PubMed][CrossRef]
21. Njoroge JW, Nguyen Y, Curtis MM, Moreira CG, Sperandio V. 2012. Virulence meets metabolism: Cra and KdpE gene regulation in enterohemorrhagic Escherichia coli. M Bio 3:e00280-12. [PubMed][CrossRef]
22. Bertin Y, Girardeau JP, Chaucheyras-Durand F, Lyan B, Pujos-Guillot E, Harel J, Martin C. 2011. Enterohaemorrhagic Escherichia coli gains a competitive advantage by using ethanolamine as a nitrogen source in the bovine intestinal content. Environ Microbiol 13:365–377. [PubMed][CrossRef]
23. Kendall MM, Gruber CC, Parker CT, Sperandio V. 2012. Ethanolamine controls expression of genes encoding components involved in interkingdom signaling and virulence in enterohemorrhagic Escherichia coli O157:H7. M Bio 3(3) :pii: e00050-12. [PubMed][CrossRef]
24. Le GT, Clermont O, Gouriou S, Picard B, Nassif X, Denamur E, Tenaillon O. 2007. Extraintestinal virulence is a coincidental by-product of commensalism in B2 phylogenetic group Escherichia coli strains. Mol Biol Evol 24:2373–2384. [PubMed][CrossRef]
25. Winter SE, Winter MG, Xavier MN, Thiennimitr P, Poon V, Keestra AM, Laughlin RC, Gomez G, Wu J, Lawhon SD, Popova IE, Parikh SJ, Adams LG, Tsolis RM, Stewart VJ, Baumler AJ. 2013. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science 339:708–711. [PubMed][CrossRef]
26. Ragnarsdottir B, Svanborg C. 2012. Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: host-pathogen interaction in urinary tract infections. Pediatr Nephrol 27:2017–2029. [PubMed][CrossRef]
27. Abou Chakra CN, Pepin J, Sirard S, Valiquette L. 2014. Risk factors for recurrence, complications and mortality in Clostridium difficile infection: a systematic review. PLoS ONE 9:e98400. [PubMed][CrossRef]
28. Abu-Ali GS, Ouellette LM, Henderson ST, Whittam TS, Manning SD. 2010. Differences in adherence and virulence gene expression between two outbreak strains of enterohaemorrhagic Escherichia coli O157:H7. Microbiology 156:408–419. [PubMed][CrossRef]
29. Kotloff KL, Nataro JP, Blackwelder WC, Nasrin D, Farag TH, Panchalingam S, Wu Y, Sow SO, Sur D, Breiman RF, Faruque AS, Zaidi AK, Saha D, Alonso PL, Tamboura B, Sanogo D, Onwuchekwa U, Manna B, Ramamurthy T, Kanungo S, Ochieng JB, Omore R, Oundo JO, Hossain A, Das SK, Ahmed S, Qureshi S, Quadri F, Adegbola RA, Antonio M, Hossain MJ, Akinsola A, Mandomando I, Nhampossa T, Acacio S, Biswas K, O'Reilly CE, Mintz ED, Berkeley LY, Muhsen K, Sommerfelt H, Robins-Browne RM, Levine MM. 2013. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet 382:209–222. [PubMed][CrossRef]
30. Levine MM, Robins-Browne RM. 2012. Factors that explain excretion of enteric pathogens by persons without diarrhea. Clin Infect Dis 55(Suppl 4) :S303–S311. [PubMed][CrossRef]
31. Lindenbaum J, Kent TH, Sprinz H. 1966. Malabsorption and jejunitis in American Peace Corps volunteers in Pakistan. Ann Intern Med 65:1201–1209. [PubMed][CrossRef]
32. Keusch GT, Denno DM, Black RE, Duggan C, Guerrant RL, Lavery JV, Nataro JP, Rosenberg IH, Ryan ET, Tarr PI, Ward H, Bhutta ZA, Coovadia H, Lima A, Ramakrishna B, Zaidi AK, Hay Burgess DC, Brewer T. 2014. Environmental enteric dysfunction: pathogenesis, diagnosis, and clinical consequences. Clin Infect Dis 59(Suppl 4) :S207–S212. [PubMed][CrossRef]
33. Sansonetti PJ, Arondel J, Huerre M, Harada A, Matsushima K. 1999. Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis. Infect Immun 67:1471–1480. [PubMed]
34. Bell BP, Griffin PM, Lozano P, Christie DL, Kobayashi JM, Tarr PI. 1997. Predictors of hemolytic uremic syndrome in children during a large outbreak of Escherichia coli O157:H7 infections. Pediatrics 100:E12. [PubMed][CrossRef]
35. Falush D, Wirth T, Linz B, Pritchard JK, Stephens M, Kidd M, Blaser MJ, Graham DY, Vacher S, Perez-Perez GI, Yamaoka Y, Megraud F, Otto K, Reichard U, Katzowitsch E, Wang X, Achtman M, Suerbaum S. 2003. Traces of human migrations in Helicobacter pylori populations. Science 299:1582–1585. [PubMed][CrossRef]
36. Chen Y, Blaser MJ. 2008. Helicobacter pylori colonization is inversely associated with childhood asthma. J Infect Dis 198:553–560. [PubMed][CrossRef]
37. Reibman J, Marmor M, Filner J, Fernandez-Beros ME, Rogers L, Perez-Perez GI, Blaser MJ. 2008. Asthma is inversely associated with Helicobacter pylori status in an urban population. PLoS ONE 3:e4060. [PubMed][CrossRef]
38. Chavali AK, Whittemore JD, Eddy JA, Williams KT, Papin JA. 2008. Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major. Mol Syst Biol 4:177. [PubMed][CrossRef]
39. Chavali AK, Blazier AS, Tlaxca JL, Jensen PA, Pearson RD, Papin JA. 2012. Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease. BMC Syst Biol 6:27. [PubMed][CrossRef]
40. D'Auria KM, Kolling GL, Donato GM, Warren CA, Gray MC, Hewlett EL, Papin JA. 2013. In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B. Infect Immun 81:3814–3824. [PubMed][CrossRef]
Loading

Article metrics loading...

/content/journal/microbiolspec/10.1128/microbiolspec.MBP-0012-2014
2015-06-11
2021-04-15

Abstract:

The field of bacterial pathogenesis has advanced dramatically in the last decade. High throughput molecular technologies have empowered scientists as never before. However, there remain some limitations, misconceptions and ambiguities in the field that may bedevil even the experienced investigator. Here, I consider some of the unanswered questions that are not readily tractable to even the most powerful technology.

Highlighted Text: Show | Hide
Loading full text...

Full text loading...

/deliver/fulltext/microbiolspec/3/3/MBP-0012-2014.html?itemId=/content/journal/microbiolspec/10.1128/microbiolspec.MBP-0012-2014&mimeType=html&fmt=ahah

Supplemental Material

No supplementary material available for this content.

Back to top
This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error