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Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections

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  • Authors: Rick M. Maizels1, James P. Hewitson2
  • Editor: Siamon Gordon3
    Affiliations: 1: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, United Kingdom; 2: Department of Biology, University of York, York YO10 5DD, United Kingdom; 3: Oxford University, Oxford, United Kingdom
  • Source: microbiolspec November 2016 vol. 4 no. 6 doi:10.1128/microbiolspec.MCHD-0043-2016
  • Received 15 July 2016 Accepted 28 September 2016 Published 23 November 2016
  • Rick M. Maizels, [email protected]
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  • Abstract:

    Many major tropical diseases are caused by long-lived helminth parasites that are able to survive by modulation of the host immune system, including the innate compartment of myeloid cells. In particular, dendritic cells and macrophages show markedly altered phenotypes during parasite infections. In addition, many specialized subsets such as eosinophils and basophils expand dramatically in response to these pathogens. The changes in phenotype and function, and their effects on both immunity to infection and reactivity to bystander antigens such as allergens, are discussed.

  • Citation: Maizels R, Hewitson J. 2016. Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections. Microbiol Spectrum 4(6):MCHD-0043-2016. doi:10.1128/microbiolspec.MCHD-0043-2016.


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Many major tropical diseases are caused by long-lived helminth parasites that are able to survive by modulation of the host immune system, including the innate compartment of myeloid cells. In particular, dendritic cells and macrophages show markedly altered phenotypes during parasite infections. In addition, many specialized subsets such as eosinophils and basophils expand dramatically in response to these pathogens. The changes in phenotype and function, and their effects on both immunity to infection and reactivity to bystander antigens such as allergens, are discussed.

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