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Molecular Basis of Drug Resistance in Mycobacterium tuberculosis
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- Authors: Keira A. Cohen1, William R. Bishai3, Alexander S. Pym4
- Editors: Graham F. Hatfull5, William R. Jacobs Jr.6
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VIEW AFFILIATIONS HIDE AFFILIATIONSAffiliations: 1: KwaZulu-Natal Research Institute for TB and HIV (K-RITH), Nelson R. Mandela School of Medicine, 719 Umbilo Road, Durban, 4001, South Africa; 2: Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115; 3: Johns Hopkins School of Medicine, The Center for TB Research, 1550 Orleans St., CRBII, Room 103, Baltimore, MD 21287; 4: KwaZulu-Natal Research Institute for TB and HIV (K-RITH), Nelson R. Mandela School of Medicine, 719 Umbilo Road, Durban, 4001, South Africa; 5: University of Pittsburgh, Pittsburgh, PA; 6: Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY
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Received 17 September 2013 Accepted 27 November 2013 Published 13 June 2014
- Correspondence: W. Bishai, [email protected]
Source:
microbiolspec
June 2014
vol. 2 no. 3 doi:10.1128/microbiolspec.MGM2-0036-2013

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Abstract:
In this chapter we review the molecular mechanisms of drug resistance to the major first- and second-line antibiotics used to treat tuberculosis.
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Citation: Cohen K, Bishai W, Pym A. 2014. Molecular Basis of Drug Resistance in Mycobacterium tuberculosis. Microbiol Spectrum 2(3):MGM2-0036-2013. doi:10.1128/microbiolspec.MGM2-0036-2013.
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Abstract:
In this chapter we review the molecular mechanisms of drug resistance to the major first- and second-line antibiotics used to treat tuberculosis.
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Molecular Basis of Drug Resistance in Mycobacterium tuberculosis
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Citation:
Cohen K, Bishai W, Pym A. 2014. Molecular basis of drug resistance in mycobacterium tuberculosis. microbiolspec 2(3): doi:10.1128/microbiolspec.MGM2-0036-2013
/content/microbiolspec/10.1128/microbiolspec.MGM2-0036-2013.T1
TABLE 1
The commonly used TB drugs with the genes associated with their respective resistance and major mechanism of resistance

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TABLE 1
The commonly used TB drugs with the genes associated with their respective resistance and major mechanism of resistance
Source:
microbiolspec
June 2014
vol. 2 no. 3 doi:10.1128/microbiolspec.MGM2-0036-2013
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