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Molecular Basis of Drug Resistance in

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  • Authors: Keira A. Cohen1, William R. Bishai3, Alexander S. Pym4
  • Editors: Graham F. Hatfull5, William R. Jacobs Jr.6
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: KwaZulu-Natal Research Institute for TB and HIV (K-RITH), Nelson R. Mandela School of Medicine, 719 Umbilo Road, Durban, 4001, South Africa; 2: Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115; 3: Johns Hopkins School of Medicine, The Center for TB Research, 1550 Orleans St., CRBII, Room 103, Baltimore, MD 21287; 4: KwaZulu-Natal Research Institute for TB and HIV (K-RITH), Nelson R. Mandela School of Medicine, 719 Umbilo Road, Durban, 4001, South Africa; 5: University of Pittsburgh, Pittsburgh, PA; 6: Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY
    • Source: microbiolspec June 2014 vol. 2 no. 3 doi:10.1128/microbiolspec.MGM2-0036-2013
  • Received 17 September 2013 Accepted 27 November 2013 Published 13 June 2014
  • W. Bishai, [email protected]
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  • Abstract:

    In this chapter we review the molecular mechanisms of drug resistance to the major first- and second-line antibiotics used to treat tuberculosis.

  • Citation: Cohen K, Bishai W, Pym A. 2014. Molecular Basis of Drug Resistance in . Microbiol Spectrum 2(3):MGM2-0036-2013. doi:10.1128/microbiolspec.MGM2-0036-2013.

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/content/journal/microbiolspec/10.1128/microbiolspec.MGM2-0036-2013
2014-06-13
2020-09-30

Abstract:

In this chapter we review the molecular mechanisms of drug resistance to the major first- and second-line antibiotics used to treat tuberculosis.

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Molecular Basis of Drug Resistance in
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Citation: Cohen K, Bishai W, Pym A. 2014. Molecular basis of drug resistance in . microbiolspec 2(3): doi:10.1128/microbiolspec.MGM2-0036-2013
/content/microbiolspec/10.1128/microbiolspec.MGM2-0036-2013.T1
TABLE 1

The commonly used TB drugs with the genes associated with their respective resistance and major mechanism of resistance

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TABLE 1

The commonly used TB drugs with the genes associated with their respective resistance and major mechanism of resistance

Source: microbiolspec June 2014 vol. 2 no. 3 doi:10.1128/microbiolspec.MGM2-0036-2013

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