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Bacterial Small RNAs in Mixed Regulatory Networks

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  • Authors: Anaïs Brosse1, Maude Guillier2
  • Editors: Gisela Storz3, Kai Papenfort4
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: CNRS UMR8261, Associated with University Paris Diderot, Sorbonne Paris Cité, Institut de Biologie Physico-Chimique, 75005 Paris, France; 2: CNRS UMR8261, Associated with University Paris Diderot, Sorbonne Paris Cité, Institut de Biologie Physico-Chimique, 75005 Paris, France; 3: Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD; 4: Department of Biology I, Microbiology, LMU Munich, Martinsried, Germany
  • Source: microbiolspec June 2018 vol. 6 no. 3 doi:10.1128/microbiolspec.RWR-0014-2017
  • Received 26 November 2017 Accepted 05 February 2018 Published 08 June 2018
  • Maude Guillier, [email protected]
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  • Abstract:

    Small regulatory RNAs are now recognized as key regulators of gene expression in bacteria. They accumulate under specific conditions, most often because their synthesis is directly controlled by transcriptional regulators, including but not limited to alternative sigma factors and response regulators of two-component systems. In turn, small RNAs regulate, mostly at the posttranscriptional level, expression of multiple genes, among which are genes encoding transcriptional regulators. Small RNAs are thus embedded in mixed regulatory circuits combining transcriptional and posttranscriptional controls, and whose properties are discussed here.

  • Citation: Brosse A, Guillier M. 2018. Bacterial Small RNAs in Mixed Regulatory Networks. Microbiol Spectrum 6(3):RWR-0014-2017. doi:10.1128/microbiolspec.RWR-0014-2017.

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/content/journal/microbiolspec/10.1128/microbiolspec.RWR-0014-2017
2018-06-08
2019-08-25

Abstract:

Small regulatory RNAs are now recognized as key regulators of gene expression in bacteria. They accumulate under specific conditions, most often because their synthesis is directly controlled by transcriptional regulators, including but not limited to alternative sigma factors and response regulators of two-component systems. In turn, small RNAs regulate, mostly at the posttranscriptional level, expression of multiple genes, among which are genes encoding transcriptional regulators. Small RNAs are thus embedded in mixed regulatory circuits combining transcriptional and posttranscriptional controls, and whose properties are discussed here.

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Figures

Image of FIGURE 1
FIGURE 1

Examples of connections between transcriptional and posttranscriptional control. Transcriptional regulators/transcriptional regulations and sRNAs/posttranscriptional regulations are in blue and red, respectively. Green nodes indicate nonregulatory target genes. Examples of TR, sRNA, or target found in the depicted circuits are given on the side, and positive or negative regulatory interactions were chosen here based on these examples. Note, however, that all regulations can be positive or negative. Known regulatory interactions between imperfectly base-pairing sRNAs and TRs in and . For clarity, target genes that do not encode regulators are not shown. Unless otherwise indicated, only direct or likely direct interactions are shown. See Table 1 for details.

Source: microbiolspec June 2018 vol. 6 no. 3 doi:10.1128/microbiolspec.RWR-0014-2017
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Image of FIGURE 2
FIGURE 2

Feedback circuit between the EnvZ-OmpR TCS and OmrA/B sRNAs. OmrA/B sRNAs are transcribed from two adjacent genes and repress expression of multiple mRNAs, including the mRNA, encoding the EnvZ-OmpR TCS. This control decreases the levels of OmpR, but without affecting that of OmpR-P, its phosphorylated form. Because transcription is directly activated by OmpR-P but also responds to the nonphosphorylated OmpR, this feedback circuit allows OmrA/B to indirectly modulate their own synthesis, while expression of other OmpR targets such as or porin genes that are regulated only by OmpR-P remains unchanged. See reference 44 for details.

Source: microbiolspec June 2018 vol. 6 no. 3 doi:10.1128/microbiolspec.RWR-0014-2017
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Tables

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TABLE 1

Examples of imperfectly base-pairing small RNAs regulated by and/or regulating TRs in and

Source: microbiolspec June 2018 vol. 6 no. 3 doi:10.1128/microbiolspec.RWR-0014-2017
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TABLE 2

Examples of connections between imperfectly base-pairing sRNAs and TRs in species other than or

Source: microbiolspec June 2018 vol. 6 no. 3 doi:10.1128/microbiolspec.RWR-0014-2017

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