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Animal Models for the Pathogenesis, Treatment, and Prevention of Infection by

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  • Authors: Susan Welkos1, Joel Bozue2, Nancy Twenhafel3, Christopher Cote4
  • Editors: Patrick Eichenberger5, Adam Driks6
    Affiliations: 1: Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702; 2: Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702; 3: Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702; 4: Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702; 5: New York University, New York, NY; 6: Loyola University Medical Center, Maywood, IL
  • Source: microbiolspec February 2015 vol. 3 no. 1 doi:10.1128/microbiolspec.TBS-0001-2012
  • Received 08 June 2012 Accepted 28 December 2014 Published 20 February 2015
  • Susan Welkos, [email protected]
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  • Abstract:

    This article reviews the characteristics of the major animal models utilized for studies on and highlights their contributions to understanding the pathogenesis and host responses to anthrax and its treatment and prevention. Advantages and drawbacks associated with each model, to include the major models (murine, guinea pig, rabbit, nonhuman primate, and rat), and other less frequently utilized models, are discussed. Although the three principal forms of anthrax are addressed, the main focus of this review is on models for inhalational anthrax. The selection of an animal model for study is often not straightforward and is dependent on the specific aims of the research or test. No single animal species provides complete equivalence to humans; however, each species, when used appropriately, can contribute to a more complete understanding of anthrax and its etiologic agent.

  • Citation: Welkos S, Bozue J, Twenhafel N, Cote C. 2015. Animal Models for the Pathogenesis, Treatment, and Prevention of Infection by . Microbiol Spectrum 3(1):TBS-0001-2012. doi:10.1128/microbiolspec.TBS-0001-2012.


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This article reviews the characteristics of the major animal models utilized for studies on and highlights their contributions to understanding the pathogenesis and host responses to anthrax and its treatment and prevention. Advantages and drawbacks associated with each model, to include the major models (murine, guinea pig, rabbit, nonhuman primate, and rat), and other less frequently utilized models, are discussed. Although the three principal forms of anthrax are addressed, the main focus of this review is on models for inhalational anthrax. The selection of an animal model for study is often not straightforward and is dependent on the specific aims of the research or test. No single animal species provides complete equivalence to humans; however, each species, when used appropriately, can contribute to a more complete understanding of anthrax and its etiologic agent.

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Methods for delivery of by the pulmonary route

Source: microbiolspec February 2015 vol. 3 no. 1 doi:10.1128/microbiolspec.TBS-0001-2012
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Animal species: comparative use as models

Source: microbiolspec February 2015 vol. 3 no. 1 doi:10.1128/microbiolspec.TBS-0001-2012

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