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in the Face of Host-Imposed Nutrient Limitation

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  • Authors: Michael Berney1, Linda Berney-Meyer2
  • Editors: William R. Jacobs Jr.3, Helen McShane4, Valerie Mizrahi5, Ian M. Orme6
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Albert Einstein College of Medicine, Department of Microbiology and Immunology, New York, NY 10461; 2: Albert Einstein College of Medicine, Department of Microbiology and Immunology, New York, NY 10461; 3: Howard Hughes Medical Institute, Albert Einstein School of Medicine, Bronx, NY 10461; 4: University of Oxford, Oxford OX3 7DQ, United Kingdom; 5: University of Cape Town, Rondebosch 7701, South Africa; 6: Colorado State University, Fort Collins, CO 80523
    • Source: microbiolspec June 2017 vol. 5 no. 3 doi:10.1128/microbiolspec.TBTB2-0030-2016
  • Received 15 September 2016 Accepted 31 March 2017 Published 09 June 2017
  • Michael Berney, [email protected]
image of <span class="jp-italic">Mycobacterium tuberculosis</span> in the Face of Host-Imposed Nutrient Limitation
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  • Abstract:

    Coevolution of pathogens and host has led to many metabolic strategies employed by intracellular pathogens to deal with the immune response and the scarcity of food during infection. Simply put, bacterial pathogens are just looking for food. As a consequence, the host has developed strategies to limit nutrients for the bacterium by containment of the intruder in a pathogen-containing vacuole and/or by actively depleting nutrients from the intracellular space, a process called nutritional immunity. Since metabolism is a prerequisite for virulence, such pathways could potentially be good targets for antimicrobial therapies. In this chapter, we review the current knowledge about the diet of , with a focus on amino acid and cofactors, discuss evidence for the bacilli’s nutritionally independent lifestyle in the host, and evaluate strategies for new chemotherapeutic interventions.

  • Citation: Berney M, Berney-Meyer L. 2017. in the Face of Host-Imposed Nutrient Limitation. Microbiol Spectrum 5(3):TBTB2-0030-2016. doi:10.1128/microbiolspec.TBTB2-0030-2016.

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/content/journal/microbiolspec/10.1128/microbiolspec.TBTB2-0030-2016
2017-06-09
2020-02-21

Abstract:

Coevolution of pathogens and host has led to many metabolic strategies employed by intracellular pathogens to deal with the immune response and the scarcity of food during infection. Simply put, bacterial pathogens are just looking for food. As a consequence, the host has developed strategies to limit nutrients for the bacterium by containment of the intruder in a pathogen-containing vacuole and/or by actively depleting nutrients from the intracellular space, a process called nutritional immunity. Since metabolism is a prerequisite for virulence, such pathways could potentially be good targets for antimicrobial therapies. In this chapter, we review the current knowledge about the diet of , with a focus on amino acid and cofactors, discuss evidence for the bacilli’s nutritionally independent lifestyle in the host, and evaluate strategies for new chemotherapeutic interventions.

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