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Tuberculosis of the Liver, Biliary Tract, and Pancreas

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  • Authors: G. Shelton McMullan1, James H. Lewis2
  • Editor: David Schlossberg3
    Affiliations: 1: Division of Gastroenterology, Georgetown University Hospital, Washington, DC 20007; 2: Division of Hepatology, Department of Medicine, Georgetown University Hospital, Washington, DC 20007; 3: Philadelphia Health Department, Philadelphia, PA
  • Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
  • Received 01 November 2016 Accepted 10 January 2017 Published 24 February 2017
  • G. Shelton McMullan, [email protected]
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  • Abstract:

    Tuberculosis of the liver, biliary tract, and pancreas is discussed. In addition, tuberculosis in the setting of HIV-AIDS and liver transplantation is explored. Drug-induced liver injury secondary to antituberculosis medication and monitoring and prophylactic treatment for such injury is also considered.

  • Citation: McMullan G, Lewis J. 2017. Tuberculosis of the Liver, Biliary Tract, and Pancreas. Microbiol Spectrum 5(1):TNMI7-0025-2016. doi:10.1128/microbiolspec.TNMI7-0025-2016.


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Tuberculosis of the liver, biliary tract, and pancreas is discussed. In addition, tuberculosis in the setting of HIV-AIDS and liver transplantation is explored. Drug-induced liver injury secondary to antituberculosis medication and monitoring and prophylactic treatment for such injury is also considered.

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Image of FIGURE 1

Tubercle comprising Langerhans giant cells, epithelioid cells, and lymphocytes. Reprinted from reference 81 , with permission.

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Image of FIGURE 2

Low-magnification hematoxylin-and-eosin-stained hepatic granuloma with giant cells. © University of Alabama at Birmingham, Department of Pathology for the PIER images.

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Image of FIGURE 3

Hypodense 13.0- by 8.0- by 7.0-cm hepatic tuberculoma with calcification. Reprinted from reference 81 , with permission.

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Image of FIGURE 4

Miliary tuberculosis of the liver. © University of Alabama at Birmingham, Department of Pathology for the PIER images.

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Histopathologic spectrum of hepatobiliary tuberculosis

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Biopsy incidence of hepatic granulomas in pulmonary tuberculosis

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Biopsy incidence of hepatic granulomas in extrapulmonary, localized hepatic, and miliary tuberculosis

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Demonstration of hepatic AFB in pulmonary tuberculosis

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Caseating granulomas in hepatic biopsy material in localized hepatic and miliary tuberculosis

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Nonspecific hepatic lesions in pulmonary tuberculosis

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Tuberculosis as a cause of hepatic granulomas

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Hepatic function tests and biochemical abnormalities in tuberculosis

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Characteristics of pancreatic tuberculosis as reported in studies involving 10 or more patients in the medical literature from 1966 to 2016

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Hepatic in AIDS

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016
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Incidence of TB-DILI

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TNMI7-0025-2016

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