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Tuberculosis in Infants and Children

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  • Authors: Gabriella S. Lamb1, Jeffrey R. Starke2
  • Editor: David Schlossberg3
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030; 2: Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030; 3: Philadelphia Health Department, Philadelphia, PA
    • Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
  • Received 25 January 2017 Accepted 01 February 2017 Published 07 April 2017
  • Jeffrey R. Starke, [email protected]
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  • Abstract:

    One million children develop tuberculosis disease each year, and 210,000 die from complications of tuberculosis. Childhood tuberculosis is very different from adult tuberculosis in epidemiology, clinical and radiographic presentation, and treatment. This review highlights the many unique features of childhood tuberculosis, with special emphasis on very young children and adolescents, who are most likely to develop disease after infection has occurred.

  • Citation: Lamb G, Starke J. 2017. Tuberculosis in Infants and Children. Microbiol Spectrum 5(2):TNMI7-0037-2016. doi:10.1128/microbiolspec.TNMI7-0037-2016.

References

1. Marais BJ, Gie RP, Schaaf HS, Beyers N, Donald PR, Starke JR. 2006. Childhood pulmonary tuberculosis: old wisdom and new challenges. Am J Respir Crit Care Med 173:1078–1090. [PubMed]
2. Perez-Velez CM, Marais BJ. 2012. Tuberculosis in children. N Engl J Med 367:348–361. [PubMed]
3. Starke JR. 2007. New concepts in childhood tuberculosis. Curr Opin Pediatr 19:306–313. [PubMed]
4. Jaganath D, Zalwango S, Okware B, Nsereko M, Kisingo H, Malone L, Lancioni C, Okwera A, Joloba M, Mayanja-Kizza H, Boom WH, Stein C, Mupere E, Tuberculosis Research Unit. 2013. Contact investigation for active tuberculosis among child contacts in Uganda. Clin Infect Dis 57:1685–1692. [PubMed]
5. Kimerling ME, Barker JT, Bruce F, Brook NL, Dunlap NE. 2000. Preventable childhood tuberculosis in Alabama: implications and opportunity. Pediatrics 105:E53. [PubMed]
6. Khan EA, Starke JR. 1995. Diagnosis of tuberculosis in children: increased need for better methods. Emerg Infect Dis 1:115–123. [PubMed]
7. Murray CJ, et al. 2014. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384:1005–1070.
8. Scott C, Kirking HL, Jeffries C, Price SF, Pratt R, Centers for Disease Control and Prevention. 2015. Tuberculosis trends—United States, 2014. MMWR Morb Mortal Wkly Rep 64:265–269. [PubMed]
9. World Health Organization. 2016. Global Tuberculosis Report, 20th ed. World Health Organization, Geneva, Switzerland.
10. Dodd PJ, Sismanidis C, Seddon JA. 2016. Global burden of drug-resistant tuberculosis in children: a mathematical modelling study. Lancet Infect Dis 16:1193–1201.
11. Dodd PJ, Gardiner E, Coghlan R, Seddon JA. 2014. Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study. Lancet Glob Health 2:e453–e459.
12. Seddon JA, Shingadia D. 2014. Epidemiology and disease burden of tuberculosis in children: a global perspective. Infect Drug Resist 7:153–165. [PubMed]
13. Centers for Disease Control and Prevention. 2015. Slide sets—epidemiology of pediatric tuberculosis in the United States, 1993–2015. https://www.cdc.gov/tb/publications/slidesets/pediatrictb/.
14. Cruz AT, Martinez BJ. 2015. Childhood tuberculosis in the United States: shifting the focus to prevention. Int J Tuberc Lung Dis 19(Suppl 1) :50–53. [PubMed]
15. Webb EA, Hesseling AC, Schaaf HS, Gie RP, Lombard CJ, Spitaels A, Delport S, Marais BJ, Donald K, Hindmarsh P, Beyers N. 2009. High prevalence of Mycobacterium tuberculosis infection and disease in children and adolescents with type 1 diabetes mellitus. Int J Tuberc Lung Dis 13:868–874. [PubMed]
16. Hargreaves JR, Boccia D, Evans CA, Adato M, Petticrew M, Porter JDH. 2011. The social determinants of tuberculosis: from evidence to action. Am J Public Health 101:654–662. [PubMed]
17. Mandalakas AM, Kirchner HL, Zhu X, Yeo KT, Starke JR. 2008. Interpretation of repeat tuberculin skin testing in international adoptees: conversions or boosting. Pediatr Infect Dis J 27:913–919. [PubMed]
18. Saiman L, Aronson J, Zhou J, Gomez-Duarte C, Gabriel PS, Alonso M, Maloney S, Schulte J. 2001. Prevalence of infectious diseases among internationally adopted children. Pediatrics 108:608–612. [PubMed]
19. Trehan I, Meinzen-Derr JK, Jamison L, Staat MA. 2008. Tuberculosis screening in internationally adopted children: the need for initial and repeat testing. Pediatrics 122:e7–e14. [PubMed]
20. Middelkoop K, Bekker LG, Myer L, Dawson R, Wood R. 2008. Rates of tuberculosis transmission to children and adolescents in a community with high adult HIV prevalence. Clin Infect Dis 47:10. [PubMed]
21. Blussé van Oud-Alblas HJ, van Vliet ME, Kimpen JL, de Villiers GS, Schaaf HS, Donald PR. 2002. Human immunodeficiency virus infection in children hospitalised with tuberculosis. Ann Trop Paediatr 22:115–123. [PubMed]
22. Lincoln EM. 1965. Epidemics of tuberculosis. Bibl Tuberc 21:157–201. [PubMed]
23. Muñoz FM, Ong LT, Seavy D, Medina D, Correa A, Starke JR. 2002. Tuberculosis among adult visitors of children with suspected tuberculosis and employees at a children’s hospital. Infect Control Hosp Epidemiol 23:568–572. [PubMed]
24. Wallgren A. 1937. On contagiousness of childhood tuberculosis. Acta Paediatr 22:229–241.
25. Curtis AB, Ridzon R, Vogel R, McDonough S, Hargreaves J, Ferry J, Valway S, Onorato IM. 1999. Extensive transmission of Mycobacterium tuberculosis from a child. N Engl J Med 341:1491–1495. [PubMed]
26. Cruz AT, Medina D, Whaley EM, Ware KM, Koy TH, Starke JR. 2011. Tuberculosis among families of children with suspected tuberculosis and employees at a children’s hospital. Infect Control Hosp Epidemiol 32:188–190. [PubMed]
27. Ahn JG, Kim DS, Kim KH. 2015. Nosocomial exposure to active pulmonary tuberculosis in a neonatal intensive care unit. Am J Infect Control 43:1292–1295. [PubMed]
28. Millership SE, Anderson C, Cummins AJ, Bracebridge S, Abubakar I. 2009. The risk to infants from nosocomial exposure to tuberculosis. Pediatr Infect Dis J 28:915–916. [PubMed]
29. Weinstein JW, Barrett CR, Baltimore RS, Hierholzer WJ, Jr. 1995. Nosocomial transmission of tuberculosis from a hospital visitor on a pediatrics ward. Pediatr Infect Dis J 14:232–234. [PubMed]
30. Starke JR. 2001. Transmission of Mycobacterium tuberculosis to and from children and adolescents. Semin Pediatr Infect Dis 12:115–122.
31. Centers for Disease Control and Prevention. 1994. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care facilities, 1994. MMWR Recommend Rep 43(RR-17) :1–132.
32. Marais BJ, Gie RP, Schaaf HS, Hesseling AC, Obihara CC, Starke JJ, Enarson DA, Donald PR, Beyers N. 2004. The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis 8:392–402. [PubMed]
33. Marais BJ, Schaaf HS. 2014. Tuberculosis in children. Cold Spring Harb Perspect Med 4:a017855. [PubMed]
34. Wallgren A. 1948. The time-table of tuberculosis. Tubercle 29:245–251. [PubMed]
35. Miller FJ, Seale RME, Taylor MD. 1963. Tuberculosis in Children, p 214. Little Brown, Boston, MA. [PubMed]
36. Norouzi S, Aghamohammadi A, Mamishi S, Rosenzweig SD, Rezaei N. 2012. Bacillus Calmette-Guérin (BCG) complications associated with primary immunodeficiency diseases. J Infect 64:543–554. [PubMed]
37. Jones C, Whittaker E, Bamford A, Kampmann B. 2011. Immunology and pathogenesis of childhood TB. Paediatr Respir Rev 12:3–8. [PubMed]
38. Newton SM, Brent AJ, Anderson S, Whittaker E, Kampmann B. 2008. Paediatric tuberculosis. Lancet Infect Dis 8:498–510. [PubMed]
39. Salazar GE, Schmitz TL, Cama R, Sheen P, Franchi LM, Centeno G, Valera C, Leyva M, Montenegro-James S, Oberhelman R, Gilman RH, Thompson MJ, Working Group on TB in Peru. 2001. Pulmonary tuberculosis in children in a developing country. Pediatrics 108:448–453. [PubMed]
40. Hesseling AC, Schaaf HS, Gie RP, Starke JR, Beyers N. 2002. A critical review of diagnostic approaches used in the diagnosis of childhood tuberculosis. Int J Tuberc Lung Dis 6:1038–1045. [PubMed]
41. World Health Organization. 2013. Systematic Screening for Active Tuberculosis. Principles and Recommendations. World Health Organization, Geneva, Switzerland. [PubMed]
42. Marais BJ. 2015. Strategies to improve tuberculosis case finding in children. Public Health Action 5:90–91. [PubMed]
43. Eang MT, Satha P, Yadav RP, Morishita F, Nishikiori N, van-Maaren P, Weezenbeek CL. 2012. Early detection of tuberculosis through community-based active case finding in Cambodia. BMC Public Health 12:469.
44. Joshi B, Chinnakali P, Shrestha A, Das M, Kumar AMV, Pant R, Lama R, Sarraf RR, Dumre SP, Harries AD. 2015. Impact of intensified case-finding strategies on childhood TB case registration in Nepal. Public Health Action 5:93–98. [PubMed]
45. American Thoracic Society. 2000. Diagnostic standards and classification of tuberculosis in adults and children. Am J Respir Crit Care Med 161:1376–1395. [PubMed]
46. Vallejo JG, Ong LT, Starke JR. 1994. Clinical features, diagnosis, and treatment of tuberculosis in infants. Pediatrics 94:1–7. [PubMed]
47. Goussard P, Gie RP, Kling S, Beyers N. 2004. Expansile pneumonia in children caused by Mycobacterium tuberculosis: clinical, radiological, and bronchoscopic appearances. Pediatr Pulmonol 38:451–455. [PubMed]
48. Piccini P, Chiappini E, Tortoli E, de Martino M, Galli L. 2014. Clinical peculiarities of tuberculosis. BMC Infect Dis 14(Suppl 1) :S4. [PubMed]
49. Teeratakulpisarn J, Lumbiganon P, Pairojkul S, Jariyaviladkul P. 1994. Cavitary tuberculosis in a young infant. Pediatr Infect Dis J 13:545–546. [PubMed]
50. Cruz AT, Hwang KM, Birnbaum GD, Starke JR. 2013. Adolescents with tuberculosis: a review of 145 cases. Pediatr Infect Dis J 32:937–941. [PubMed]
51. Marais BJ, Gie RP, Hesseling AH, Beyers N. 2005. Adult-type pulmonary tuberculosis in children 10–14 years of age. Pediatr Infect Dis J 24:743–744. [PubMed]
52. Nemir RL, Krasinski K. 1988. Tuberculosis in children and adolescents in the 1980s. Pediatr Infect Dis J 7:375–379. [PubMed]
53. Marais BJ, Gie RP, Schaaf HS, Starke JR, Hesseling AC, Donald PR, Beyers N. 2004. A proposed radiological classification of childhood intra-thoracic tuberculosis. Pediatr Radiol 34:886–894. [PubMed]
54. Delacourt C, Mani TM, Bonnerot V, de Blic J, Sayeg N, Lallemand D, Scheinmann P. 1993. Computed tomography with normal chest radiograph in tuberculous infection. Arch Dis Child 69:430–432. [PubMed]
55. Matsaniotis N, Kattamis C, economou-Mavrou E, Kyriazakou M. 1967. Bullous emphysema in childhood tuberculosis. J Pediatr 71:703–708. [PubMed]
56. de Pontual L, Balu L, Ovetchkine P, Maury-Tisseron B, Lachassinne E, Cruaud P, Jeantils V, Valeyre D, Fain O, Gaudelus J. 2006. Tuberculosis in adolescents: a French retrospective study of 52 cases. Pediatr Infect Dis J 25:930–932. [PubMed]
57. Lincoln EM, Davies PA, Bovornkitti S. 1958. Tuberculous pleurisy with effusion in children; a study of 202 children with particular reference to prognosis. Am Rev Tuberc 77:271–289. [PubMed]
58. Cruz AT, Ong LT, Starke JR. 2009. Childhood pleural tuberculosis: a review of 45 cases. Pediatr Infect Dis J 28:981–984. [PubMed]
59. Lusiba JK, Nakiyingi L, Kirenga BJ, Kiragga A, Lukande R, Nsereko M, Ssengooba W, Katamba A, Worodria W, Joloba ML, Mayanja-Kizza H. 2014. Evaluation of Cepheid’s Xpert MTB/Rif test on pleural fluid in the diagnosis of pleural tuberculosis in a high prevalence HIV/TB setting. PLoS One 9:e102702. [PubMed]
60. Pang CS, Shen YC, Tian PW, Zhu J, Feng M, Wan C, Wen FQ. 2015. Accuracy of the interferon-gamma release assay for the diagnosis of tuberculous pleurisy: an updated meta-analysis. PeerJ 3:e951. [PubMed]
61. Marais BJ, Wright CA, Schaaf HS, Gie RP, Hesseling AC, Enarson DA, Beyers N. 2006. Tuberculous lymphadenitis as a cause of persistent cervical lymphadenopathy in children from a tuberculosis-endemic area. Pediatr Infect Dis J 25:142–146. [PubMed]
62. Wright CA, Hesseling AC, Bamford C, Burgess SM, Warren R, Marais BJ. 2009. Fine-needle aspiration biopsy: a first-line diagnostic procedure in paediatric tuberculosis suspects with peripheral lymphadenopathy? Int J Tuberc Lung Dis 13:1373–1379. [PubMed]
63. Wright CA, Warren RM, Marais BJ. 2009. Fine needle aspiration biopsy: an undervalued diagnostic modality in paediatric mycobacterial disease. Int J Tuberc Lung Dis 13:1467–1475. [PubMed]
64. Sharma SK, Mohan A, Sharma A. 2012. Challenges in the diagnosis & treatment of miliary tuberculosis. Indian J Med Res 135:703–730. [PubMed]
65. Sharma SK, Mohan A, Sharma A, Mitra DK. 2005. Miliary tuberculosis: new insights into an old disease. Lancet Infect Dis 5:415–430.
66. Ho J, Marais BJ, Gilbert GL, Ralph AP. 2013. Diagnosing tuberculous meningitis—have we made any progress? Trop Med Int Health 18:783–793. [PubMed]
67. Hussey G, Chisholm T, Kibel M. 1991. Miliary tuberculosis in children: a review of 94 cases. Pediatr Infect Dis J 10:832–836. [PubMed]
68. Schuit KE. 1979. Miliary tuberculosis in children. Clinical and laboratory manifestation in 19 patients. Am J Dis Child 133:583–585. [PubMed]
69. van der Weert EM, Hartgers NM, Schaaf HS, Eley BS, Pitcher RD, Wieselthaler NA, Laubscher R, Donald PR, Schoeman JF. 2006. Comparison of diagnostic criteria of tuberculous meningitis in human immunodeficiency virus-infected and uninfected children. Pediatr Infect Dis J 25:65–69. [PubMed]
70. Doerr CA, Starke JR, Ong LT. 1995. Clinical and public health aspects of tuberculous meningitis in children. J Pediatr 127:27–33. [PubMed]
71. Rock RB, Olin M, Baker CA, Molitor TW, Peterson PK. 2008. Central nervous system tuberculosis: pathogenesis and clinical aspects. Clin Microbiol Rev 21:243–261. [PubMed]
72. van Well GTJ, Paes BF, Terwee CB, Springer P, Roord JJ, Donald PR, van Furth AM, Schoeman JF. 2009. Twenty years of pediatric tuberculous meningitis: a retrospective cohort study in the western cape of South Africa. Pediatrics 123:e1–e8. [PubMed]
73. Donald PR, Schaaf HS, Schoeman JF. 2005. Tuberculous meningitis and miliary tuberculosis: the Rich focus revisited. J Infect 50:193–195. [PubMed]
74. van Toorn R, Rabie H, Dramowski A, Schoeman JF. 2012. Neurological manifestations of TB-IRIS: a report of 4 children. Eur J Paediatr Neurol 16:676–682. [PubMed]
75. Afghani B, Lieberman JM. 1994. Paradoxical enlargement or development of intracranial tuberculomas during therapy: case report and review. Clin Infect Dis 19:1092–1099. [PubMed]
76. Thwaites GE, Macmullen-Price J, Tran TH, Pham PM, Nguyen TD, Simmons CP, White NJ, Tran TH, Summers D, Farrar JJ. 2007. Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study. Lancet Neurol 6:230–236.
77. Venturini E, Turkova A, Chiappini E, Galli L, de Martino M, Thorne C. 2014. Tuberculosis and HIV co-infection in children. BMC Infect Dis 14(Suppl 1) :S5. [PubMed]
78. Dangor Z, Izu A, Hillier K, Solomon F, Beylis N, Moore DP, Nunes MC, Madhi SA. 2013. Impact of the antiretroviral treatment program on the burden of hospitalization for culture-confirmed tuberculosis in South African children: a time-series analysis. Pediatr Infect Dis J 32:972–977. [PubMed]
79. Hesseling AC, Cotton MF, Jennings T, Whitelaw A, Johnson LF, Eley B, Roux P, Godfrey-Faussett P, Schaaf HS. 2009. High incidence of tuberculosis among HIV-infected infants: evidence from a South African population-based study highlights the need for improved tuberculosis control strategies. Clin Infect Dis 48:108–114. [PubMed]
80. Chan SP, Birnbaum J, Rao M, Steiner P. 1996. Clinical manifestation and outcome of tuberculosis in children with acquired immunodeficiency syndrome. Pediatr Infect Dis J 15:443–447. [PubMed]
81. Braitstein P, Nyandiko W, Vreeman R, Wools-Kaloustian K, Sang E, Musick B, Sidle J, Yiannoutsos C, Ayaya S, Carter EJ. 2009. The clinical burden of tuberculosis among human immunodeficiency virus-infected children in Western Kenya and the impact of combination antiretroviral treatment. Pediatr Infect Dis J 28:626–632. [PubMed]
82. Chintu C, Mwaba P. 2005. Tuberculosis in children with human immunodeficiency virus infection. Int J Tuberc Lung Dis 9:477–484. [PubMed]
83. Stop TB Partnership Childhood TB Subgroup. 2006. Chapter 3: management of TB in the HIV-infected child. Int J Tuberc Lung Dis 10:1331–1336. [PubMed]
84. Hesseling AC, Westra AE, Werschkull H, Donald PR, Beyers N, Hussey GD, El-Sadr W, Schaaf HS. 2005. Outcome of HIV infected children with culture confirmed tuberculosis. Arch Dis Child 90:1171–1174. [PubMed]
85. Elenga N, Kouakoussui KA, Bonard D, Fassinou P, Anaky MF, Wemin ML, Dick-Amon-Tanoh F, Rouet F, Vincent V, Msellati P. 2005. Diagnosed tuberculosis during the follow-up of a cohort of human immunodeficiency virus-infected children in Abidjan, Côte d’Ivoire: ANRS 1278 study. Pediatr Infect Dis J 24:1077–1082. [PubMed]
86. Lawn SD, Mwaba P, Bates M, Piatek A, Alexander H, Marais BJ, Cuevas LE, McHugh TD, Zijenah L, Kapata N, Abubakar I, McNerney R, Hoelscher M, Memish ZA, Migliori GB, Kim P, Maeurer M, Schito M, Zumla A. 2013. Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test. Lancet Infect Dis 13:349–361.
87. World Health Organization. 2014. Xpert MTB/RIF Implementation Manual. World Health Organization, Geneva, Switzerland.
88. Azzopardi P, Bennett CM, Graham SM, Duke T. 2009. Bacille Calmette-Guérin vaccine-related disease in HIV-infected children: a systematic review. Int J Tuberc Lung Dis 13:1331–1344. [PubMed]
89. Hesseling AC, Rabie H, Marais BJ, Manders M, Lips M, Schaaf HS, Gie RP, Cotton MF, van Helden PD, Warren RM, Beyers N. 2006. Bacille Calmette-Guérin vaccine-induced disease in HIV-infected and HIV-uninfected children. Clin Infect Dis 42:548–558. [PubMed]
90. Hesseling AC, Cotton MF, Fordham von Reyn C, Graham SM, Gie RP, Hussey GD. 2008. Consensus statement on the revised World Health Organization recommendations for BCG vaccination in HIV-infected infants. Int J Tuberc Lung Dis 12:1376–1379. [PubMed]
91. Martinson NA, Moultrie H, van Niekerk R, Barry G, Coovadia A, Cotton M, Violari A, Gray GE, Chaisson RE, McIntyre JA, Meyers T. 2009. HAART and risk of tuberculosis in HIV-infected South African children: a multi-site retrospective cohort. Int J Tuberc Lung Dis 13:862–867. [PubMed]
92. Puthanakit T, Oberdorfer P, Akarathum N, Wannarit P, Sirisanthana T, Sirisanthana V. 2006. Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children. Pediatr Infect Dis J 25:53–58. [PubMed]
93. Eamranond P, Jaramillo E. 2001. Tuberculosis in children: reassessing the need for improved diagnosis in global control strategies. Int J Tuberc Lung Dis 5:594–603. [PubMed]
94. Huebner RE, Schein MF, Bass JB, Jr. 1993. The tuberculin skin test. Clin Infect Dis 17:968–975. [PubMed]
95. Shingadia D, Novelli V. 2003. Diagnosis and treatment of tuberculosis in children. Lancet Infect Dis 3:624–632. [PubMed]
96. American Academy of Pediatrics. 2015. 2015 Red Book: Report of the Committee on Infectious Diseases, 28th ed. American Academy of Pediatrics, Elk Grove Village, IL.
97. Pediatric Tuberculosis Collaborative. 2004. Targeted tuberculin skin testing and treatment of latent tuberculosis infection in children and adolescents. Pediatrics 114(Suppl 4) :1175–1201.
98. Steiner P, Rao M, Victoria MS, Jabbar H, Steiner M. 1980. Persistently negative tuberculin reactions: their presence among children with culture positive for Mycobacterium tuberculosis (tuberculin-negative tuberculosis). Am J Dis Child 134:747–750. [PubMed]
99. Nayak S, Acharjya B. 2012. Mantoux test and its interpretation. Indian Dermatol Online J 3:2–6. [PubMed]
100. Sepulveda RL, Burr C, Ferrer X, Sorensen RU. 1988. Booster effect of tuberculin testing in healthy 6-year-old school children vaccinated with Bacillus Calmette-Guérin at birth in Santiago, Chile. Pediatr Infect Dis J 7:578–581. [PubMed]
101. Bianchi L, Galli L, Moriondo M, Veneruso G, Becciolini L, Azzari C, Chiappini E, de Martino M. 2009. Interferon-gamma release assay improves the diagnosis of tuberculosis in children. Pediatr Infect Dis J 28:510–514. [PubMed]
102. Mazurek GH, Jereb J, Vernon A, LoBue P, Goldberg S, Castro K, IGRA Expert Committee, Centers for Disease Control and Prevention. 2010. Updated guidelines for using interferon gamma release assays to detect Mycobacterium tuberculosis infection—United States, 2010. MMWR Recommend Rep 59(RR-5) :1–25. [PubMed]
103. Detjen AK, Keil T, Roll S, Hauer B, Mauch H, Wahn U, Magdorf K. 2007. Interferon-gamma release assays improve the diagnosis of tuberculosis and nontuberculous mycobacterial disease in children in a country with a low incidence of tuberculosis. Clin Infect Dis 45:322–328. [PubMed]
104. Laurenti P, Raponi M, de Waure C, Marino M, Ricciardi W, Damiani G. 2016. Performance of interferon-γ release assays in the diagnosis of confirmed active tuberculosis in immunocompetent children: a new systematic review and meta-analysis. BMC Infect Dis 16:131. [PubMed]
105. Machingaidze S, Wiysonge CS, Gonzalez-Angulo Y, Hatherill M, Moyo S, Hanekom W, Mahomed H. 2011. The utility of an interferon gamma release assay for diagnosis of latent tuberculosis infection and disease in children: a systematic review and meta-analysis. Pediatr Infect Dis J 30:694–700. [PubMed]
106. Mandalakas AM, Detjen AK, Hesseling AC, Benedetti A, Menzies D. 2011. Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis. Int J Tuberc Lung Dis 15:1018–1032. [PubMed]
107. Starke JR. 2014. Interferon-γ release assays for diagnosis of tuberculosis infection and disease in children. Pediatrics 134:e1763–e1773. [PubMed]
108. Sun L, Xiao J, Miao Q, Feng WX, Wu XR, Yin QQ, Jiao WW, Shen C, Liu F, Shen D, Shen AD. 2011. Interferon gamma release assay in diagnosis of pediatric tuberculosis: a meta-analysis. FEMS Immunol Med Microbiol 63:165–173. [PubMed]
109. Blandinières A, de Lauzanne A, Guérin-El Khourouj V, Gourgouillon N, See H, Pédron B, Faye A, Sterkers G. 2013. QuantiFERON to diagnose infection by Mycobacterium tuberculosis: performance in infants and older children. J Infect 67:391–398. [PubMed]
110. Connell TG, Ritz N, Paxton GA, Buttery JP, Curtis N, Ranganathan SC. 2008. A three-way comparison of tuberculin skin testing, QuantiFERON-TB gold and T-SPOT.TB in children. PLoS One 3:e2624–e2631. [PubMed]
111. Hill PC, Brookes RH, Adetifa IMO, Fox A, Jackson-Sillah D, Lugos MD, Donkor SA, Marshall RJ, Howie SR, Corrah T, Jeffries DJ, Adegbola RA, McAdam KP. 2006. Comparison of enzyme-linked immunospot assay and tuberculin skin test in healthy children exposed to Mycobacterium tuberculosis. Pediatrics 117:1542–1548. [PubMed]
112. Lighter J, Rigaud M, Eduardo R, Peng CH, Pollack H. 2009. Latent tuberculosis diagnosis in children by using the QuantiFERON-TB Gold In-Tube test. Pediatrics 123:30–37. [PubMed]
113. Nicol MP, Davies MA, Wood K, Hatherill M, Workman L, Hawkridge A, Eley B, Wilkinson KA, Wilkinson RJ, Hanekom WA, Beatty D, Hussey G, Hussey G. 2009. Comparison of T-SPOT.TB assay and tuberculin skin test for the evaluation of young children at high risk for tuberculosis in a community setting. Pediatrics 123:38–43. [PubMed]
114. Sali M, Buonsenso D, Goletti D, D’Alfonso P, Zumbo A, Fadda G, Sanguinetti M, Delogu G, Valentini P. 2015. Accuracy of QuantiFERON-TB Gold test for tuberculosis diagnosis in children. PLoS One 10:e0138952. [PubMed]
115. Soysal A, Türel O, Toprak D, Bakir M. 2008. Comparison of positive tuberculin skin test with an interferon-gamma-based assay in unexposed children. Jpn J Infect Dis 61:192–195. [PubMed]
116. Moyo S, Isaacs F, Gelderbloem S, Verver S, Hawkridge AJ, Hatherill M, Tameris M, Geldenhuys H, Workman L, Pai M, Hussey G, Hanekom WA, Mahomed H. 2011. Tuberculin skin test and QuantiFERON® assay in young children investigated for tuberculosis in South Africa. Int J Tuberc Lung Dis 15:1176–1181, i. [PubMed]
117. Critselis E, Amanatidou V, Syridou G, Spyridis NP, Mavrikou M, Papadopoulos NG, Tsolia MN. 2012. The effect of age on whole blood interferon-gamma release assay response among children investigated for latent tuberculosis infection. J Pediatr 161:632–638. [PubMed]
118. Debord C, De Lauzanne A, Gourgouillon N, Guérin-El Khourouj V, Pédron B, Gaudelus J, Faye A, Sterkers G. 2011. Interferon-gamma release assay performance for diagnosing tuberculosis disease in 0- to 5-year-old children. Pediatr Infect Dis J 30:995–997. [PubMed]
119. Lewinsohn DA, Lobato MN, Jereb JA. 2010. Interferon-gamma release assays: new diagnostic tests for Mycobacterium tuberculosis infection, and their use in children. Curr Opin Pediatr 22:71–76. [PubMed]
120. Mandalakas AM, Hesseling AC, Chegou NN, Kirchner HL, Zhu X, Marais BJ, Black GF, Beyers N, Walzl G. 2008. High level of discordant IGRA results in HIV-infected adults and children. Int J Tuberc Lung Dis 12:417–423. [PubMed]
121. Mandalakas AM, van Wyk S, Kirchner HL, Walzl G, Cotton M, Rabie H, Kriel B, Gie RP, Schaaf HS, Hesseling AC. 2013. Detecting tuberculosis infection in HIV-infected children: a study of diagnostic accuracy, confounding and interaction. Pediatr Infect Dis J 32:e111–e118. [PubMed]
122. Stefan DC, Dippenaar A, Detjen AK, Schaaf HS, Marais BJ, Kriel B, Loebenberg L, Walzl G, Hesseling AC. 2010. Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer. Int J Tuberc Lung Dis 14:689–694. [PubMed]
123. Winthrop KL, Weinblatt ME, Daley CL. 2012. You can’t always get what you want, but if you try sometimes (with two tests—TST and IGRA—for tuberculosis) you get what you need. Ann Rheum Dis 71:1757–1760. [PubMed]
124. Cruz AT, Revell PA, Starke JR. 2013. Gastric aspirate yield for children with suspected pulmonary tuberculosis. J Pediatric Infect Dis Soc 2:171–174. [PubMed]
125. Laven GT. 1977. Diagnosis of tuberculosis in children using fluorescence microscopic examination of gastric washings. Am Rev Respir Dis 115:743–749. [PubMed]
126. Dunn JJ, Starke JR, Revell PA. 2016. Laboratory diagnosis of Mycobacterium tuberculosis infection and disease in children. J Clin Microbiol 54:1434–1441. [PubMed]
127. Giammona ST, Zelkowitz PS. 1969. Superheated nebulized saline and gastric lavage to obtain bacterial cultures in primary pulmonary tuberculosis in children. Am J Dis Child 117:198–200.
128. Oberhelman RA, Soto-Castellares G, Gilman RH, Caviedes L, Castillo ME, Kolevic L, Del Pino T, Saito M, Salazar-Lindo E, Negron E, Montenegro S, Laguna-Torres VA, Moore DA, Evans CA. 2010. Diagnostic approaches for paediatric tuberculosis by use of different specimen types, culture methods, and PCR: a prospective case-control study. Lancet Infect Dis 10:612–620.
129. Schaaf HS, Marais BJ, Whitelaw A, Hesseling AC, Eley B, Hussey GD, Donald PR. 2007. Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of 596 cases. BMC Infect Dis 7:140–147. [PubMed]
130. Zar HJ, Hanslo D, Apolles P, Swingler G, Hussey G. 2005. Induced sputum versus gastric lavage for microbiological confirmation of pulmonary tuberculosis in infants and young children: a prospective study. Lancet 365:130–134.
131. Grant LR, Hammitt LL, Murdoch DR, O’Brien KL, Scott JA. 2012. Procedures for collection of induced sputum specimens from children. Clin Infect Dis 54(Suppl 2) :S140–S145. [PubMed]
132. Ruiz Jiménez M, Guillén Martín S, Prieto Tato LM, Cacho Calvo JB, Álvarez García A, Soto Sánchez B, Ramos Amador JT. 2013. Induced sputum versus gastric lavage for the diagnosis of pulmonary tuberculosis in children. BMC Infect Dis 13:222. [PubMed]
133. Iriso R, Mudido PM, Karamagi C, Whalen C. 2005. The diagnosis of childhood tuberculosis in an HIV-endemic setting and the use of induced sputum. Int J Tuberc Lung Dis 9:716–726. [PubMed]
134. Moore HA, Apolles P, de Villiers PJ, Zar HJ. 2011. Sputum induction for microbiological diagnosis of childhood pulmonary tuberculosis in a community setting. Int J Tuberc Lung Dis 15:1185–1190, i. [PubMed]
135. Abadco DL, Steiner P. 1992. Gastric lavage is better than bronchoalveolar lavage for isolation of Mycobacterium tuberculosis in childhood pulmonary tuberculosis. Pediatr Infect Dis J 11:735–738.
136. Chan S, Abadco DL, Steiner P. 1994. Role of flexible fiberoptic bronchoscopy in the diagnosis of childhood endobronchial tuberculosis. Pediatr Infect Dis J 13:506–509. [PubMed]
137. Cakir E, Uyan ZS, Oktem S, Karakoc F, Ersu R, Karadag B, Dagli E. 2008. Flexible bronchoscopy for diagnosis and follow up of childhood endobronchial tuberculosis. Pediatr Infect Dis J 27:783–787. [PubMed]
138. Delacourt C, Poveda JD, Chureau C, Beydon N, Mahut B, de Blic J, Scheinmann P, Garrigue G. 1995. Use of polymerase chain reaction for improved diagnosis of tuberculosis in children. J Pediatr 126:703–709. [PubMed]
139. Gomez-Pastrana D, Torronteras R, Caro P, Anguita ML, López-Barrio AM, Andres A, Navarro J. 2001. Comparison of amplicor, in-house polymerase chain reaction, and conventional culture for the diagnosis of tuberculosis in children. Clin Infect Dis 32:17–22. [PubMed]
140. Pierre C, Olivier C, Lecossier D, Boussougant Y, Yeni P, Hance AJ. 1993. Diagnosis of primary tuberculosis in children by amplification and detection of mycobacterial DNA. Am Rev Respir Dis 147:420–424. [PubMed]
141. Smith KC, Starke JR, Eisenach K, Ong LT, Denby M. 1996. Detection of Mycobacterium tuberculosis in clinical specimens from children using a polymerase chain reaction. Pediatrics 97:155–160. [PubMed]
142. Detjen AK, DiNardo AR, Leyden J, Steingart KR, Menzies D, Schiller I, Dendukuri N, Mandalakas AM. 2015. Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis. Lancet Respir Med 3:451–461. [PubMed]
143. Singh S, Singh A, Prajapati S, Kabra SK, Lodha R, Mukherjee A, Singh V, Hesseling AC, Grewal HMS, Delhi Pediatric TB study group. 2015. Xpert MTB/RIF assay can be used on archived gastric aspirate and induced sputum samples for sensitive diagnosis of paediatric tuberculosis. BMC Microbiol 15:191. [PubMed]
144. Denkinger CM, Schumacher SG, Boehme CC, Dendukuri N, Pai M, Steingart KR. 2014. Xpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis: a systematic review and meta-analysis. Eur Respir J 44:435–446. [PubMed]
145. Lanciella L, Lo Vecchio A, Chiappini E, Tadolini M, Cirrilo D, Tortoli E, de Martino M, Guarino A, Principi N, Villani A, Esposito S, Galli L. 2015. How to manage children who have come into contact with patients affected by tuberculosis. J Clin Tuberc Other Mycobact Dis 1:1–12.
146. Pediatric Tuberculosis Collaborative Group. 2004. Diagnosis and treatment of latent tuberculosis infection in children and adolescents. Pediatrics 114:1175–1201.
147. Seddon JA, Fred D, Amanullah F, Schaaf HS, Starke JR, Keshavjee S, Burzynski J, Furin JJ, Swaminathan S, Becerra MC. 2015. Post-exposure Management of Multidrug-Resistant Tuberculosis Contacts: Evidence-Based Recommendations. Policy Brief No. 1. Harvard Medical School Center for Global Health Delivery-Dubai, Dubai, United Arab Emirates.
148. Dormer BA, Harrison I, Swart JA, Vidor SR. 1959. Prophylactic isoniazid: protection of infants in a tuberculosis hospital. Lancet ii:902–903. [PubMed]
149. Ferebee SH. 1970. Controlled chemoprophylaxis trials in tuberculosis. A general review. Bibl Tuberc 26:28–106. [PubMed]
150. Hsu KHK. 1984. Thirty years after isoniazid. Its impact on tuberculosis in children and adolescents. JAMA 251:1283–1285. [PubMed]
151. O’Brien RJ, Long MW, Cross FS, Lyle MA, Snider DE, Jr. 1983. Hepatotoxicity from isoniazid and rifampin among children treated for tuberculosis. Pediatrics 72:491–499. [PubMed]
152. Comstock GW, Livesay VT, Woolpert SF. 1974. The prognosis of a positive tuberculin reaction in childhood and adolescence. Am J Epidemiol 99:131–138. [PubMed]
153. Nahid P, Dorman SE, Alipanah N, Barry PM, Brozek JL, Cattamanchi A, Chaisson LH, Chaisson RE, Daley CL, Grzemska M, Higashi JM, Ho CS, Hopewell PC, Keshavjee SA, Lienhardt C, Menzies R, Merrifield C, Narita M, O’Brien R, Peloquin CA, Raftery A, Saukkonen J, Schaaf HS, Sotgiu G, Starke JR, Migliori GB, Vernon A. 2016. Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical practice guidelines: treatment of drug-susceptible tuberculosis. Clin Infect Dis 63:e147–e195. [PubMed]
154. Comstock GW, Baum C, Snider DE, Jr. 1979. Isoniazid prophylaxis among Alaskan Eskimos: a final report of the bethel isoniazid studies. Am Rev Respir Dis 119:827–830. [PubMed]
155. Comstock GW, Hammes LM, Pio A. 1969. Isoniazid prophylaxis in Alaskan boarding schools. A comparison of two doses. Am Rev Respir Dis 100:773–779. [PubMed]
156. McIlleron H, Willemse M, Werely CJ, Hussey GD, Schaaf HS, Smith PJ, Donald PR. 2009. Isoniazid plasma concentrations in a cohort of South African children with tuberculosis: implications for international pediatric dosing guidelines. Clin Infect Dis 48:1547–1553. [PubMed]
157. Spyridis NP, Spyridis PG, Gelesme A, Sypsa V, Valianatou M, Metsou F, Gourgiotis D, Tsolia MN. 2007. The effectiveness of a 9-month regimen of isoniazid alone versus 3- and 4-month regimens of isoniazid plus rifampin for treatment of latent tuberculosis infection in children: results of an 11-year randomized study. Clin Infect Dis 45:715–722. [PubMed]
158. Cruz AT, Ahmed A, Mandalakas AM, Starke JR. 2013. Treatment of latent tuberculosis infection in children. J Pediatric Infect Dis Soc 2:248–258. [PubMed]
159. Cruz AT, Starke JR. 2012. Increasing adherence for latent tuberculosis infection therapy with health department-administered therapy. Pediatr Infect Dis J 31:193–195. [PubMed]
160. Horsburgh CR, Jr, Goldberg S, Bethel J, Chen S, Colson PW, Hirsch-Moverman Y, Hughes S, Shrestha-Kuwahara R, Sterling TR, Wall K, Weinfurter P, Tuberculosis Epidemiologic Studies Consortium. 2010. Latent TB infection treatment acceptance and completion in the United States and Canada. Chest 137:401–409. [PubMed]
161. Hong Kong Chest Service/Tuberculosis Research Center. Madras/British Medical Research Council. 1992. A double-blind placebo-controlled clinical trial of three antituberculosis chemoprophylaxis regimens in patients with silicosis in Hong Kong. Am Rev Respir Dis 145:36–41.
162. Menzies D, Long R, Trajman A, Dion MJ, Yang J, Al Jahdali H, Memish Z, Khan K, Gardam M, Hoeppner V, Benedetti A, Schwartzman K. 2008. Adverse events with 4 months of rifampin therapy or 9 months of isoniazid therapy for latent tuberculosis infection: a randomized trial. Ann Intern Med 149:689–697. [PubMed]
163. Villarino ME, Scott NA, Weis SE, Weiner M, Conde MB, Jones B, Nachman S, Oliveira R, Moro RN, Shang N, Goldberg SV, Sterling TR, International Maternal Pediatric and Adolescents AIDS Clinical Trials Group, Tuberculosis Trials Consortium. 2015. Treatment for preventing tuberculosis in children and adolescents: a randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and isoniazid. JAMA Pediatr 169:247–255. [PubMed]
164. Cruz AT, Starke JR. 2016. Safety and adherence for 12 weekly doses of isoniazid and rifapentine for pediatric tuberculosis infection. Pediatr Infect Dis J 35:811–813. [PubMed]
165. Thee S, Seddon JA, Donald PR, Seifart HI, Werely CJ, Hesseling AC, Rosenkranz B, Roll S, Magdorf K, Schaaf HS. 2011. Pharmacokinetics of isoniazid, rifampin, and pyrazinamide in children younger than two years of age with tuberculosis: evidence for implementation of revised World Health Organization recommendations. Antimicrob Agents Chemother 55:5560–5567. [PubMed]
166. World Health Organization. 2010. Rapid Advice: Treatment of Tuberculosis in Children. World Health Organization, Geneva, Switzerland.
167. Cruz AT, Starke JR. 2008. Treatment of tuberculosis in children. Expert Rev Anti Infect Ther 6:939–957. [PubMed]
168. Reis FJ, Bedran MB, Moura JA, Assis I, Rodrigues ME. 1990. Six-month isoniazid-rifampin treatment for pulmonary tuberculosis in children. Am Rev Respir Dis 142:996–999. [PubMed]
169. Al-Dossary FS, Ong LT, Correa AG, Starke JR. 2002. Treatment of childhood tuberculosis with a six month directly observed regimen of only two weeks of daily therapy. Pediatr Infect Dis J 21:91–97. [PubMed]
170. Kumar L, Dhand R, Singhi PD, Rao KL, Katariya S. 1990. A randomized trial of fully intermittent vs. daily followed by intermittent short course chemotherapy for childhood tuberculosis. Pediatr Infect Dis J 9:802–806. [PubMed]
171. Te Water Naude JM, Donald PR, Hussey GD, Kibel MA, Louw A, Perkins DR, Schaaf HS. 2000. Twice weekly vs. daily chemotherapy for childhood tuberculosis. Pediatr Infect Dis J 19:405–410. [PubMed]
172. Tsakalidis D, Pratsidou P, Hitoglou-Makedou A, Tzouvelekis G, Sofroniadis I. 1992. Intensive short course chemotherapy for treatment of Greek children with tuberculosis. Pediatr Infect Dis J 11:1036–1042. [PubMed]
173. Donald PR, Maher D, Maritz JS, Qazi S. 2006. Ethambutol dosage for the treatment of children: literature review and recommendations. Int J Tuberc Lung Dis 10:1318–1330. [PubMed]
174. Stop TB Partnership Childhood TB Subgroup. 2006. Chapter 2: antituberculosis treatment in children. Int J Tuberc Lung Dis 10:1205–1211. [PubMed]
175. Jawahar MS, Rajaram K, Sivasubramanian S, Paramasivan CN, Chandrasekar K, Kamaludeen MN, Thirithuvathas AJ, Ananthalakshmi V, Prabhakar R. 2005. Treatment of lymph node tuberculosis—a randomized clinical trial of two 6-month regimens. Trop Med Int Health 10:1090–1098. [PubMed]
176. Biddulph J. 1990. Short course chemotherapy for childhood tuberculosis. Pediatr Infect Dis J 9:794–801. [PubMed]
177. Agarwal A, Khan SA, Qureshi NA. 2011. Multifocal osteoarticular tuberculosis in children. J Orthop Surg (Hong Kong) 19:336–340. [PubMed]
178. Visudhiphan P, Chiemchanya S. 1989. Tuberculous meningitis in children: treatment with isoniazid and rifampicin for twelve months. J Pediatr 114:875–879. [PubMed]
179. Jacobs RF, Sunakorn P, Chotpitayasunonah T, Pope S, Kelleher K. 1992. Intensive short course chemotherapy for tuberculous meningitis. Pediatr Infect Dis J 11:194–198. [PubMed]
180. Li H, Lu J, Liu J, Zhao Y, Ni X, Zhao S. 2016. Linezolid is associated with improved early outcomes of childhood tuberculous meningitis. Pediatr Infect Dis J 35:607–610. [PubMed]
181. Thwaites GE, van Toorn R, Schoeman J. 2013. Tuberculous meningitis: more questions, still too few answers. Lancet Neurol 12:999–1010. [PubMed]
182. Schoeman JF, Van Zyl LE, Laubscher JA, Donald PR. 1997. Effect of corticosteroids on intracranial pressure, computed tomographic findings, and clinical outcome in young children with tuberculous meningitis. Pediatrics 99:226–231. [PubMed]
183. Farinha NJ, Razali KA, Holzel H, Morgan G, Novelli VM. 2000. Tuberculosis of the central nervous system in children: a 20-year survey. J Infect 41:61–68. [PubMed]
184. Centers for Disease Control. 1983. Interstate outbreak of drug-resistant tuberculosis involving children—California, Montana, Nevada, Utah. MMWR Morb Mortal Wkly Rep 32:516–518. [PubMed]
185. Schaaf HS, Gie RP, Beyers N, Sirgel FA, de Klerk PJ, Donald PR. 2000. Primary drug-resistant tuberculosis in children. Int J Tuberc Lung Dis 4:1149–1155. [PubMed]
186. Steiner P, Rao M, Mitchell M, Steiner M. 1985. Primary drug-resistant tuberculosis in children. Correlation of drug-susceptibility patterns of matched patient and source case strains of Mycobacterium tuberculosis. Am J Dis Child 139:780–782. [PubMed]
187. Ridzon R, Kent JH, Valway S, Weismuller P, Maxwell R, Elcock M, Meador J, Royce S, Shefer A, Smith P, Woodley C, Onorato I. 1997. Outbreak of drug-resistant tuberculosis with second-generation transmission in a high school in California. J Pediatr 131:863–868.
188. Partners in Health, World Health Organization. 2009. Management of MDR-TB: A Field Guide. World Health Organization, Geneva, Switzerland. http://apps.who.int/iris/bitstream/10665/44163/1/9789241547765_eng.pdf.
189. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis. 2015. Management of Multidrug-Resistant Tuberculosis in Children: A Field Guide, 2nd ed. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis, Boston, MA. http://sentinel-project.org/wp-content/uploads/2015/03/Field_Handbook_2nd_Ed_revised-no-logos_03022015.pdf.
190. Steiner P, Rao M. 1993. Drug-resistant tuberculosis in children. Semin Pediatr Infect Dis 4:275–292.
191. Swanson DS, Starke JR. 1995. Drug-resistant tuberculosis in pediatrics. Pediatr Clin North Am 42:553–581. [PubMed]
192. Schaaf HS, Willemse M, Donald PR. 2009. Long-term linezolid treatment in a young child with extensively drug-resistant tuberculosis. Pediatr Infect Dis J 28:748–750. [PubMed]
193. Palacios E, Dallman R, Muñoz M, Hurtado R, Chalco K, Guerra D, Mestanza L, Llaro K, Bonilla C, Drobac P, Bayona J, Lygizos M, Anger H, Shin S. 2009. Drug-resistant tuberculosis and pregnancy: treatment outcomes of 38 cases in Lima, Peru. Clin Infect Dis 48:1413–1419. [PubMed]
194. World Health Organization. 2016. Treatment Guidelines for Drug-Resistant Tuberculosis. World Health Organization, Geneva, Switzerland.
195. Feja K, McNelley E, Tran CS, Burzynski J, Saiman L. 2008. Management of pediatric multidrug-resistant tuberculosis and latent tuberculosis infections in New York City from 1995 to 2003. Pediatr Infect Dis J 27:907–912. [PubMed]
196. D’Ambrosio L, Centis R, Sotgiu G, Pontali E, Spanevello A, Migliori GB. 2015. New anti-tuberculosis drugs and regimens: 2015 update. ERJ Open Res 1:00010-2015. [PubMed]
197. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis. 2016. Rapid Clinical Advice: The Use of Delamanid and Bedaquiline for Children with Drug-Resistant Tuberculosis. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis, Boston, MA. http://sentinel-project.org/wp-content/uploads/2016/05/Rapid-Clinical-Advice_May-16-2016.pdf.
198. Hafkin J, et al. 2015. Long-term safety, tolerability, and pharmacokinetics of delamanid in pediatric MDR-TB patients ages 12–17 years, poster EP-115-04. 46th Union World Conf Lung Health, 2 to 6 December 2015, Cape Town, South Africa.
199. Hafkin J, et al. 2015. Pharmacokinetics and safety of delamanid in pediatric MDR-TB patients, ages 6–17 years, poster A-960, Int Conf Antimicrob Agents Chemother, 18 to 21 September 2015, San Diego, CA.
200. Tadolini M, Garcia-Prats AJ, D’Ambrosio L, Hewison C, Centis R, Schaaf HS, Marias BJ, Ferreira H, Caminero JA, Jonckheere S, Sinha A, Herboczek K, Khaidarkhanova Z, Hayrapetyan A, Khachatryan N, Urtkmelidze I, Loreti C, Esposito S, Matteelli A, Furin J, Varaine F, Miliori GB. 2016. Compassionate use of new drugs in children and adolescents with multidrug-resistant tuberculosis; early experiences and challenges. Eur Respir J 48:938–943. [PubMed]
201. Powell DA, Perkins L, Wang SH, Hunt G, Ryan-Wenger N. 2008. Completion of therapy for latent tuberculosis in children of different nationalities. Pediatr Infect Dis J 27:272–274. [PubMed]
202. Donald PR, Maher D, Qazi S. 2007. A research agenda to promote the management of childhood tuberculosis within national tuberculosis programs. Int J Tuberc Lung Dis 11:327–380.
203. World Health Organization. 2014. Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children. World Health Organization, Geneva, Switzerland.
204. American Thoracic Society, Centers for Disease Control and Prevention, Infectious Diseases Society of America. 2005. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: controlling tuberculosis in the United States. Am J Respir Crit Care Med 172:1169–1227. [PubMed]
205. Lobato MN, Mohle-Boetani JC, Royce SE. 2000. Missed opportunities for preventing tuberculosis among children younger than five years of age. Pediatrics 106:E75. [PubMed]
206. Lobato MN, Sun SJ, Moonan PK, Weis SE, Saiman L, Reichard AA, Feja K, Zero Tolerance for Pediatric TB Study Group. 2008. Underuse of effective measures to prevent and manage pediatric tuberculosis in the United States. Arch Pediatr Adolesc Med 162:426–431. [PubMed]
207. World Health Organization Stop TB Partnership Childhood TB Subgroup. 2007. Chapter 4: childhood contact screening and management. Int J Tuberc Lung Dis 11:12–15. [PubMed]
208. Mohle-Boetani JC, Miller B, Halpern M, Trivedi A, Lessler J, Solomon SL, Fenstersheib M. 1995. School-based screening for tuberculous infection. A cost-benefit analysis. JAMA 274:613–619.
209. Cruz AT, Starke JR. 2011. A current review of infection control for childhood tuberculosis. Tuberculosis (Edinburgh) 91(Suppl 1) :S11–S15. [PubMed]
210. Mohle-Boetani JC, Flood J. 2002. Contact investigations and the continued commitment to control tuberculosis. JAMA 287:1040–1042. [PubMed]
211. Hatzenbuehler LA, Starke JR, Graviss EA, Smith EO, Cruz AT. 2016. School-based study to identify and treat adolescent students at risk for tuberculosis infection. Pediatr Infect Dis J 35:733–738. [PubMed]
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2017-04-07
2021-04-21

Abstract:

One million children develop tuberculosis disease each year, and 210,000 die from complications of tuberculosis. Childhood tuberculosis is very different from adult tuberculosis in epidemiology, clinical and radiographic presentation, and treatment. This review highlights the many unique features of childhood tuberculosis, with special emphasis on very young children and adolescents, who are most likely to develop disease after infection has occurred.

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Tuberculosis in Infants and Children
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Citation: Lamb G, Starke J. 2017. Tuberculosis in infants and children. microbiolspec 5(2): doi:10.1128/microbiolspec.TNMI7-0037-2016
/content/microbiolspec/10.1128/microbiolspec.TNMI7-0037-2016.fig1
FIGURE 1
Tuberculosis (TB) case rates by age group for children, 1993 to 2015. (Data in the public domain, courtesy of the CDC.)
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FIGURE 1

Tuberculosis (TB) case rates by age group for children, 1993 to 2015. (Data in the public domain, courtesy of the CDC.)

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
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FIGURE 2
Early collapse-consolidation lesion in a child with tuberculosis. Mediastinal adenopathy also is present on the right side.
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FIGURE 2

Early collapse-consolidation lesion in a child with tuberculosis. Mediastinal adenopathy also is present on the right side.

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
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FIGURE 3
Slightly more extensive right-sided adenopathy with atelectasis in a 2-year-old with tuberculosis.
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FIGURE 3

Slightly more extensive right-sided adenopathy with atelectasis in a 2-year-old with tuberculosis.

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
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FIGURE 4
Well-formed collapse-consolidation lesion on the right, with large mediastinal and hilar adenopathy and atelectasis.
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FIGURE 4

Well-formed collapse-consolidation lesion on the right, with large mediastinal and hilar adenopathy and atelectasis.

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
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FIGURE 5
Tuberculous pneumonia with bowing of the horizontal fissure. Children with this finding may have an associated bacterial infection.
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FIGURE 5

Tuberculous pneumonia with bowing of the horizontal fissure. Children with this finding may have an associated bacterial infection.

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FIGURE 6
Reactivation-type tuberculosis in an adolescent boy.
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FIGURE 6

Reactivation-type tuberculosis in an adolescent boy.

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FIGURE 7
A tuberculous pleural effusion in an adolescent girl.
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FIGURE 7

A tuberculous pleural effusion in an adolescent girl.

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FIGURE 8
Miliary tuberculosis in an infant. The child presented with fever and respiratory distress.
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FIGURE 8

Miliary tuberculosis in an infant. The child presented with fever and respiratory distress.

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
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FIGURE 9
Magnetic resonance imaging showing abnormal enhancement along the basilar cisterns, acute ischemia or possibly cerebritis involving the right caudate head, right putaminal and possibly right globus pallidus, ventriculomegaly (ventriculoperitoneal shunt in place), and enhancement along multiple cranial nerves.
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FIGURE 9

Magnetic resonance imaging showing abnormal enhancement along the basilar cisterns, acute ischemia or possibly cerebritis involving the right caudate head, right putaminal and possibly right globus pallidus, ventriculomegaly (ventriculoperitoneal shunt in place), and enhancement along multiple cranial nerves.

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
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FIGURE 10
A helpful technique for applying the Mantoux TST on a child. The hand is anchored on the side of the child’s arm, providing stability. The tuberculin is injected in a lateral direction.
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FIGURE 10

A helpful technique for applying the Mantoux TST on a child. The hand is anchored on the side of the child’s arm, providing stability. The tuberculin is injected in a lateral direction.

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
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FIGURE 11
An algorithm for the use of the TST and IGRAs in children. Entry into the algorithm assumes that the child has at least 1 risk factor for TB infection. Note: many experts use age <2 years as the starting point. Reprinted from reference 107 , with permission from the American Academy of Pediatrics Committee on Infectious Diseases.
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FIGURE 11

An algorithm for the use of the TST and IGRAs in children. Entry into the algorithm assumes that the child has at least 1 risk factor for TB infection. Note: many experts use age <2 years as the starting point. Reprinted from reference 107 , with permission from the American Academy of Pediatrics Committee on Infectious Diseases.

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
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Tables

Tuberculosis in Infants and Children
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Citation: Lamb G, Starke J. 2017. Tuberculosis in infants and children. microbiolspec 5(2): doi:10.1128/microbiolspec.TNMI7-0037-2016
/content/microbiolspec/10.1128/microbiolspec.TNMI7-0037-2016.T1
TABLE 1
Childhood tuberculosis cases with any extrapulmonary involvement by age group and selected sites of disease, United States, 1993 to 2015
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TABLE 1

Childhood tuberculosis cases with any extrapulmonary involvement by age group and selected sites of disease, United States, 1993 to 2015

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
/content/microbiolspec/10.1128/microbiolspec.TNMI7-0037-2016.T2
TABLE 2
Symptoms and signs of childhood pulmonary tuberculosis
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TABLE 2

Symptoms and signs of childhood pulmonary tuberculosis

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
/content/microbiolspec/10.1128/microbiolspec.TNMI7-0037-2016.T3
TABLE 3
Comparison of chest radiographs of pulmonary tuberculosis in adults and children
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TABLE 3

Comparison of chest radiographs of pulmonary tuberculosis in adults and children

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
/content/microbiolspec/10.1128/microbiolspec.TNMI7-0037-2016.T4
TABLE 4
First-line drugs for the treatment of tuberculosis in children
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TABLE 4

First-line drugs for the treatment of tuberculosis in children

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016
/content/microbiolspec/10.1128/microbiolspec.TNMI7-0037-2016.T5
TABLE 5
Drugs used for treatment of MDR tuberculosis in children
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TABLE 5

Drugs used for treatment of MDR tuberculosis in children

Source: microbiolspec April 2017 vol. 5 no. 2 doi:10.1128/microbiolspec.TNMI7-0037-2016

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