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Reservoirs of Extraintestinal Pathogenic

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  • Authors: Amee R. Manges1, James R. Johnson2
  • Editors: Matthew A. Mulvey4, Ann E. Stapleton5, David J. Klumpp6
    Affiliations: 1: School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; 2: Infectious Diseases Section, Veterans Affairs Medical Center, Minneapolis, MN 55417; 3: Department of Medicine, University of Minnesota, Minneapolis, MN 55455; 4: University of Utah, Salt Lake City, UT; 5: University of Washington, Seattle, WA; 6: Northwestern University, Chicago, IL
  • Source: microbiolspec September 2015 vol. 3 no. 5 doi:10.1128/microbiolspec.UTI-0006-2012
  • Received 26 July 2012 Accepted 09 October 2014 Published 04 September 2015
  • Amee R. Manges, [email protected]
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  • Abstract:

    Several potential reservoirs for the strains that cause most human extraintestinal infections (extraintestinal pathogenic ; ExPEC) have been identified, including the human intestinal tract and various non-human reservoirs, such as companion animals, food animals, retail meat products, sewage, and other environmental sources. Understanding ExPEC reservoirs, chains of transmission, transmission dynamics, and epidemiologic associations will assist greatly in finding ways to reduce the ExPEC-associated disease burden. The need to clarify the ecological behavior of ExPEC is all the more urgent because environmental reservoirs may contribute to acquisition of antimicrobial resistance determinants and selection for and amplification of resistant ExPEC. In this chapter, we review the evidence for different ExPEC reservoirs, with particular attention to food and food animals, and discuss the public health implications of these reservoirs for ExPEC dissemination and transmission.

  • Citation: Manges A, Johnson J. 2015. Reservoirs of Extraintestinal Pathogenic . Microbiol Spectrum 3(5):UTI-0006-2012. doi:10.1128/microbiolspec.UTI-0006-2012.


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Several potential reservoirs for the strains that cause most human extraintestinal infections (extraintestinal pathogenic ; ExPEC) have been identified, including the human intestinal tract and various non-human reservoirs, such as companion animals, food animals, retail meat products, sewage, and other environmental sources. Understanding ExPEC reservoirs, chains of transmission, transmission dynamics, and epidemiologic associations will assist greatly in finding ways to reduce the ExPEC-associated disease burden. The need to clarify the ecological behavior of ExPEC is all the more urgent because environmental reservoirs may contribute to acquisition of antimicrobial resistance determinants and selection for and amplification of resistant ExPEC. In this chapter, we review the evidence for different ExPEC reservoirs, with particular attention to food and food animals, and discuss the public health implications of these reservoirs for ExPEC dissemination and transmission.

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The tree, which is drawn to scale, was inferred using the Neighbor-Joining method, based on concatenated DNA sequences from the seven MLST loci. was used to root the tree, but for simplicity has been excluded. All positions containing gaps and missing data were eliminated. There were a total of 3423 positions in the final dataset.

Source: microbiolspec September 2015 vol. 3 no. 5 doi:10.1128/microbiolspec.UTI-0006-2012
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