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Uropathogenic -Associated Exotoxins

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  • Author: Rodney A. Welch1
  • Editors: Matthew A. Mulvey2, Ann E. Stapleton3, David J. Klumpp4
    Affiliations: 1: Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706; 2: University of Utah, Salt Lake City, UT; 3: University of Washington, Seattle, WA; 4: Northwestern University, Chicago, IL
  • Source: microbiolspec June 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.UTI-0011-2012
  • Received 17 August 2012 Accepted 23 July 2015 Published 10 June 2016
  • Rodney A. Welch, [email protected]
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  • Abstract:

    are a common cause of infectious disease outside of the gastrointestinal tract. Several independently evolved clades are common causes of urinary tract and bloodstream infections. There is ample epidemiological and evidence that several different protein toxins common to many, but not all, of these strains are likely to aid the colonization and immune-evasion ability of these bacteria. This review discusses our current knowledge and areas of ignorance concerning the contribution of the hemolysin; cytotoxic-necrotizing factor-1; and the autotransporters, Sat, Pic, and Vat, to extraintestinal human disease.

  • Citation: Welch R. 2016. Uropathogenic -Associated Exotoxins. Microbiol Spectrum 4(3):UTI-0011-2012. doi:10.1128/microbiolspec.UTI-0011-2012.


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are a common cause of infectious disease outside of the gastrointestinal tract. Several independently evolved clades are common causes of urinary tract and bloodstream infections. There is ample epidemiological and evidence that several different protein toxins common to many, but not all, of these strains are likely to aid the colonization and immune-evasion ability of these bacteria. This review discusses our current knowledge and areas of ignorance concerning the contribution of the hemolysin; cytotoxic-necrotizing factor-1; and the autotransporters, Sat, Pic, and Vat, to extraintestinal human disease.

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Prominent protein toxins of uropathogenic

Source: microbiolspec June 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.UTI-0011-2012

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